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61.
体外丹参、藻酸双酯钠对脑血栓形成患者红细胞与内皮细胞粘附的影响 总被引:3,自引:0,他引:3
丹参、藻酸双酯钠是临床治疗脑血管病的常用药。本研究发现,在体外流场中用丹参、藻酸双酯钠分别处理脑血栓形成病人的红细胞后,此红细胞与培养的人脉静脉内皮细胞的粘附数目明显减少、粘附强度明显减弱;而且,在临床常用剂量下藻酸双酯钠的这种抗粘附作用优于丹参。认为丹参、藻酸双酯钠的这种抗粘附作用可能是临床用以治疗脑血栓形成的一个重要机理。 相似文献
62.
FOREWORDPeritonealdialysisrepresentssoluteandfluidexchangemainlybetweenperitonealcapillarybloodanddialysissolutionintheperitonealcavity'CombinedwithhemodialySisandrenaltransplantation,peritonealdialysisisusedmainlyforthetreatmentofrenalfailure,particularlyforchronicfailure'In1976,Prof'Popovichdevelopedcontinuousambulatoryperitonealdialysis(CAPD)basingontheconceptofcontinuousequilibrationdialysis('1'Fromthenon,peritonealdialysisfounditsclinicaluse'Continuouscyclicperitonealdialysis(CCPD… 相似文献
63.
Antonio C. Buzaid David S. Alberts Janine Eispahr Kurt Mosley Yei-Mei Peng Kendra Tutsch Collin P. Spears Harinder S. Garewal 《Cancer chemotherapy and pharmacology》1989,25(2):124-130
Summary Dipyridamole (DP) has previously been studied both in vitro and in vivo in combination with various antimetabolites, including methotrexate and 5-fluorouracil (5FU). We evaluated in vitro and clinically the effects of adding DP to fluorodeoxyuridine (FUDR) in colorectal cancer. Using a human colony-forming assay, we observed that 0.05 M DP increased the cytotoxicity of FUDR by a median of 33.5-fold vs 1.5-fold for 5FU against human colon-cancer cell lines. The mechanism of the DP-enhanced antitumor activity of FUDR is not completely understood but appears to be related to a profound inhibition by DP of thymidine accumulation in and FUDR efflux from colon-cancer cell lines. On the basis of these in vitro results, 28 patients with metastatic colon cancer were entered in a clinical trial of monthly courses of 0.1 mg/kg FUDR daily for 14 days and 75 mg oral DP 5 times daily for 14 days starting on the 3rd day of continuous i.v. FUDR infusion. The pharmacokinetics of DP was studied in three patients; the results showed that 98% of total serum DP was protein-bound and that free DP levels were significantly lower than the concentrations necessary for the expected in vitro DP/FUDR modulation. Treatment was well tolerated, with only 12 patients developing mild to moderate toxicity. Of 27 evaluable patients, 4 achieved a partial response that lasted 2, 3, 5, and 6+ months. This relatively low response rate (15%), which is similar to that achieved with FUDR alone, may be explained by the low steady-state plasma concentrations of free DP achieved in our patients. Other means of DP administration, such as i.v., i.a., and i.p. injection, may be required to achieve free DP concentrations necessary for successful biochemical modulation of FUDR in patients.Supported in part by grants CA17094, CA23074, and CA39629 from the National Institutes of Health, Bethesda, Md 20205, and a grant from the Arizona Chronic Disease Commission. HSG is a recipient of an American Cancer Society Career Development Award 相似文献
64.
Peng?Dong Ling?Ling?Wong Sarah?Ng Marie?Loh Adrian?MondryEmail author 《BMC medical informatics and decision making》2004,4(1):21
Background
Critically Appraised Topics (CATs) are a useful tool that helps physicians to make clinical decisions as the healthcare moves towards the practice of Evidence-Based Medicine (EBM). The fast growing World Wide Web has provided a place for physicians to share their appraised topics online, but an increasing amount of time is needed to find a particular topic within such a rich repository.Methods
A web-based application, namely the CAT Crawler, was developed by Singapore's Bioinformatics Institute to allow physicians to adequately access available appraised topics on the Internet. A meta-search engine, as the core component of the application, finds relevant topics following keyword input. The primary objective of the work presented here is to evaluate the quantity and quality of search results obtained from the meta-search engine of the CAT Crawler by comparing them with those obtained from two individual CAT search engines. From the CAT libraries at these two sites, all possible keywords were extracted using a keyword extractor. Of those common to both libraries, ten were randomly chosen for evaluation. All ten were submitted to the two search engines individually, and through the meta-search engine of the CAT Crawler. Search results were evaluated for relevance both by medical amateurs and professionals, and the respective recall and precision were calculated.Results
While achieving an identical recall, the meta-search engine showed a precision of 77.26% (±14.45) compared to the individual search engines' 52.65% (±12.0) (p < 0.001).Conclusion
The results demonstrate the validity of the CAT Crawler meta-search engine approach. The improved precision due to inherent filters underlines the practical usefulness of this tool for clinicians.65.
66.
人和大鼠腰椎关节突关节的SP能神经纤维的分布 总被引:2,自引:0,他引:2
目的:证实支配腰椎关节突关节的神经支配和化学性质,方法:用逆行荧光素标记结合免疫组化法,研究7只大鼠腰部脊神经节细胞的周围突分支投射到腰椎关节突关节及其递质性质以及3例人腰椎关节突关节囊上神经末梢的化学性质,结果:发现大鼠一侧L5和L6之间的关节突关节受同侧L2-5节段的脊神经节的部分细胞周围突分支支配,其中有33.399%的中型和小型细胞为中SP能免疫反应阳性,人的关节突关节囊含有SP阳性的神经 相似文献
67.
腰骶部SPR术中脊神经前后根定位的应用解剖 总被引:13,自引:6,他引:13
目的:为SPR提供可靠的术中脊神经前、后根鉴别的解剖学依据。方法:在20例成人脊柱标本上,去除后部结构,暴露整个马尾神经,对L1~S2节段的前后根进行形态学观察和测量。结果:脊神经后根位于马尾的后半部,前根则位于前半部。脊神经后根较相应的前根粗大,后根从L1~S1逐渐增大,以S1为最粗大;前根则以L3最粗大。相应前后根出硬脊膜前,有一段相互贴附并紧贴硬脊膜侧壁。结论:在多椎板切除SPR术中前、后根的定位及鉴别,暴露时可根据前、后根出硬脊膜前的相互贴附;在限制性椎板切除时则可通过脊髓外侧索和L1前、后根之间的最下端的齿状韧带加以鉴别 相似文献
68.
H W Peng T S Su S H Han C K Ho C H Ho K N Ching B N Chiang 《Journal of medical virology》1988,24(4):405-412
In order to study the prevalence of hepatitis B virus (HBV) in the adult population of Taiwan, we screened for the presence of HBV DNA in 205 blood samples from adult (20-59-year-old) volunteers. According to the serological markers of HBV, samples were divided into three groups: group I (173 subjects) was negative for both HBsAg and HBeAg; group II (14 subjects) was positive for both HBsAg and HBeAg; and group III consisted of 18 subjects who were HBsAg-positive but HBeAg-negative. Plasma HBV DNA was not detected in group I, but it was found in 85.7% and 11.8% of samples in group II and group III, respectively. A free-form HBV DNA was found in 14.3% of the leukocyte samples in group II. Furthermore, an integrated form of HBV DNA was detected in the leukocytes of two cases of group I who remained healthy based on clinical data. HBV DNA was also detected in the spermatozoa and liver cells of one of the cases. 相似文献
69.
Yuan B. Peng Qing Lin W. D. Willis 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1997,114(3):561-570
The effects of a protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), on the activity and periaqueductal gray (PAG)-induced inhibition of rat dorsal horn
neurons of the lumbar spinal cord were tested. A microdialysis fiber was placed through the dorsal horn for the purpose of
local application of pharmacological agents. Extracellular single-unit recordings from dorsal horn neurons were made near
the microdialysis fiber. TPA was tested on nociceptive dorsal horn cells. There was a significant increase in the background
activity and responses to ”brush”, with no changes in responses to pressure and pinch stimuli. TPA also significantly blocked
the PAG-induced inhibition of responses to brush, press, and pinch. These effects were eliminated by coadministration of the
PKC inhibitor NPC-15437. The solvent, which contained dimethyl sulfoxide, was also tested for its effect on the responses
to peripheral mechanical stimuli and PAG-induced inhibition of the dorsal horn neurons. There were no significant changes.
This experiment suggests that activation of the PKC second messenger system might increase the activity of dorsal horn neurons
and their responses to peripheral stimuli; in addition, the phorbol ester attenuated the PAG-induced descending inhibition
of the dorsal horn neuron activity.
Received: 15 May 1996 / Accepted: 14 November 1996 相似文献
70.