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31.
目的 观察内膜损伤后血管狭窄的主要病理变化和此过程中血浆内血管内皮素(endothelin ,ET)水平的动态变化及局部动脉组织内ET反应性 (ET immunoreaction ,ET IR) ,探讨卡托普利 (Captopril)对动脉球囊损伤后狭窄的影响。方法 大耳白兔 4 8只 ,依术后处死时间不同 (6h和 1、3、7、15、2 2d)按随机表法随机分为 6组 ,每组 8只 ,其中 3只为内膜损伤 (手术组 )、3只为损伤 卡托普利治疗 (治疗组 ) ,2只为对照组。术前及术后均采静脉血 ,手术组及治疗组置入微球囊导管于腹主动脉内制备内膜损伤模型。治疗组术前 1d给予卡托普利 2mg·kg-1·d-1直至处死当日。放射免疫法检测术前、术后血浆内ET水平 ,处死后取模型动脉血管 ,观察血管内膜厚度及管腔病理变化 ,免疫组织化学法检测动脉组织内ET反应。结果 手术组各时间段血浆ET水平 [平均值 (139 17± 16 86 )ng/L) ]和治疗组各时间段血浆ET水平 [平均值 (12 2 16± 13 5 6 )ng/L]均较术前 [平均值 (111 2 4±11 39)ng/L]升高 (P <0 0 1和P <0 0 5 ) ,手术组术后各时间段血浆ET水平比治疗组及对照组有明显升高 (P值均 <0 0 1) ,而治疗组与对照组术后血浆ET水平无显著性差异 ;手术组动脉内膜有不同程度增厚 ,主要以血管平滑肌细胞 (vascularsmoothmusclec 相似文献
32.
医疗扶贫是提高贫困人口健康的一个重要措施,也是社会公平性的具体体现。文章从医疗扶贫项目开展的社会需求、扶贫项目的组织与管理、扶贫资金的筹集、扶贫项目可利用的资源等诸多方面论证医疗扶贫项目的可持续性。分析结果认为,在我国继续开展医疗扶贫有其必要性和可行性。 相似文献
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36.
一种具有高信噪比的脉搏波光电传感器的研制 总被引:5,自引:0,他引:5
目的:探讨研制一种生理信号光电传感器。方法:利用光电传感器检测通过指端毛细血管后的光强度的变化,将光信号转换成电信号,再经过电信号1/V转换、放大、滤波处理。结果:获得了清晰稳定的指端容积脉搏波。结论:高信噪比的光电传感器可用作于临床监测和生理信号分析处理系统。 相似文献
37.
EffectofCaptoprilonAntithrombusFunctionofEndotheliumXIONGYi-li(熊一力);ZHAOHua-yue(赵华月)(DepartmentofMedicine,TongjiHospital,Tong... 相似文献
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The concave and convex rib-vertebral angle (RVA) at levels T2–T12 was measured on AP radiographs of 19 patients with right convex idiopathic thoracic scoliosis and 10 patients with major thoracic right convex neuromuscular scoliosis. The difference between the angles on the concave and the convex sides, the RVAD, was calculated. The RVAs were also measured on radiographs from three animal groups in which spinal curves had been induced experimentally in a variety of ways. Group 1 comprised 16 rabbits that had been subjected to selective electrostimulation of the latissimus dorsi, the erector spinae and the intercostal muscles. Group 2 comprised four dead rabbits whose spines had been subjected to manual bending. Group 3 comprised eight rabbits that had undergone mechanical elongation of one rib. In both the idiopathic and the neuromuscular group, the convex RVA was smaller than the concave RVA between levels T2 and T8, with a maximal difference between T4 to T5. From T9 to T12 the concave RVA was smaller than the convex. The RVA in relation to the scoliotic segment, i.e. the apex level of the curve and the two neighbouring vertebrae above and below this level, showed similar results. With increasing Cobb angle the RVADs increased linearly with the greatest difference at the second vertebra above the apex. In the three experimental groups the pattern of the RVADs between T6 to T12 was basically similar to the findings of the clinical study. From the results of these clinical and experimental studies, it is concluded that the typical pattern of the RVAs on the concave and convex sides seems to be independent of the underlying cause of the spinal curvature. It is likely that the RVADs result from a passive mechanical adaptation of the ribs to the lateral curvature of the spine. 相似文献
40.
Summary 24 model rabbits with femoral arterial thrombosis were divided into two grocps: the treatment group consisting of 12 rabbits
which received API0134. and the control group composed of another 12 rabbits. 2 hours after recanalization by urokinase thrombolysis, reocilusion
occurred only in 1/12 vessel (8%) with incomplete occlusion in the treated group, but in 8/12 (67%) with complete occlusion
in the control group as assessed by angiograsphy. Pathological examination of specimen taken 24 hours after thrombolysis showed
that 6/12 (50%) of the treated group gave the evidence of thrombus occlusion, and milder intimai injury and less adhered blood
cells than in the control group, 83% of which had thrombus occlusion. In comparision with the control group, the function
of platelet in the treated group demonstrated lower platelet aggregation rate (PAgR) and plasma thromboxane A2 (TXA2) level, higher prostacyclin (PGI2) and plasminogen activator (PA) activity as well as lower plasminogen activator inhibitor (PAI) activity. From the above
it may be concluded that the preventive effect of API0134 on reocclusion might be due to inhibition of platelets aggregation and promotion of fibrinolysis. 相似文献