Factors Associated with Macular Staphyloma Area on Ultra-widefield Fundus Images

PurposeTo assess the feasibility of applying ultra-widefield fundus (UWF) images for macular staphyloma area (MSA) measurement and investigate the associated factors with MSA.MethodsThis is a retrospective study. MSA was measured by UWF imaging. Central foveal thickness, subfoveal choroidal thickness, subfoveal scleral thickness were measured on spectral domain optical coherence tomography. Intraclass correlation coefficients of MSA measurement would be evaluated. Multiple linear regression analysis was used to analyze the associated factors with MSA.ResultsIn total, 135 eyes of 92 patients were enrolled. The mean age was 64.73 ± 10.84 years. Mean MSA on UWF image was 279.67 ± 71.70 mm². Intraclass correlation coefficients of MSA measurement was 0.965 (95% confidence interval [CI], 0.946 to 0.977; p < 0.001). In the multiple linear regression analysis, after adjusting for subfoveal choroidal thickness, best-corrected visual acuity, central foveal thickness, and subfoveal scleral thickness, the factors independently related to MSA were axial length (β = 8.352; 95% CI, 3.306 to 13.398; p = 0.001), sex (β = −26.673; 95% CI, −51.759 to −1.586; p = 0.037), age (β = 1.184; 95% CI, 0.020 to 2.348; p = 0.046).ConclusionsIt is feasible to measure MSA on UWF image. Female, longer axial length, and older age may indicate larger MSA.     

新型冠状病毒肺炎后潜水员适潜性评估

新型冠状病毒肺炎（COVID?19）自2019年底爆发以来,对人类生命健康造成了极其严重的危害。作为一种呼吸系统疾病,COVID?19对全身几乎所有器官都会产生影响,其中最主要的受累器官为肺和心脏。随着COVID?19 “康复”患者数量不断增加,越来越多的证据表明,因COVID?19而住院治疗得到“康复”的患者中有相当大比例的人群存在着后遗症,主要表现为呼吸系统和心血管系统的症状。对于潜水员,COVID-19后运动耐受、心肺功能的恢复对于其适潜性具有重要的影响。一些组织和机构对于潜水员COVID-19后的适潜性评估,发布了指南。本文对COVID-19后呼吸和心血管后遗症以及相关的适潜性评估方案进行简要介绍,并基于已有的相关要求和我国实际,初步提出我国潜水员COVID-19后的适潜性评估要求。     

赴泰国旅客旅行健康知识及行为调查分析

目的了解石家庄机场赴泰国旅客对当地高发传染病的认知现状和个人防护能力情况,为制定高风险航线往来旅客的风险分析方案提供依据。方法采取随机抽样方法,对由石家庄机场赴泰国游的旅客在知情同意的情况下进行面对面的问卷调查,所有资料录入Excel后采用SPSS 13.0软件进行统计分析。结果回收的503份有效调查问卷中,本科学历、收入中等偏上、第一次出境旅游的中青年人群为主体,具有目前出境游人群的代表性;有效问卷中,65.8%的人选择通过旅行社了解赴泰国旅行注意事项;大多数旅客集中选择泰国是"登革热"(42.5%)和"疟疾"(25.2%)的流行区域,而选择"痢疾"和"霍乱"的只占14.1%和11.9%;58.1%的旅客出境前未接种过任何疫苗;23.7%旅客不知道应该到哪里进行旅行前的健康咨询,13.1%不清楚归国后如有发热、皮疹等传染病症状该如何就医。结论评价口岸传染病防控能力现状,逐步构建主动型卫生检疫查验系统;完善风险评估机制,有针对性地对重点航班和人群采取多举措宣教以提升防病意识;应多部门联合持续加强出入境人员的传染病宣教、监测和防控工作。     

婴儿型庞贝病1例护理

<正>庞贝病(又称为糖原累积病Ⅱ型)是一种常染色体隐性遗传病,其特征是溶酶体酸性α-葡糖苷酶(ac-id alpha-glucosidase,GAA)基因突变导致GAA酶活性降低或缺乏,糖原不能分解而贮积在各种组织的溶酶体内,导致心肌、呼吸肌及骨骼肌等进行性损害,以及各种神经功能损害^[1]。根据临床症状出现的时间,该病可分成婴儿型庞贝病(infantile-onset Pompe disease,IOPD)和晚发型庞贝病(late-onset Pompe disease,LOPDIOPD     

Veganism does not reduce the risk of the metabolic syndrome in a Taiwanese cohort

The purpose of the present study was to assess the risk of the metabolic syndrome (MS) with vegan, pescovegetarian, lactovegetarian and nonvegetarian diets in Taiwan. The design was a retrospective cohort study using secondary data analysis from a Taiwan longitudinal health check-up database provided by MJ Health Screening Center during 1996-2006. A total of 93209 participants were classified as vegans (n=1116), pescovegetarians (n=2461), lactovegetarians (n=4313) and nonvegetarians (n=85319) by food frequency list of self-administered questionnaire at baseline. The association between MS or MS components and different dietary groups was evaluated using Cox proportional-hazards regression models with adjustment for confounders. During the mean 3.75 years of follow up, a total 8006 MS incident cases occurred and the incidence of MS was 229 (95% CI, 224, 234) per 10000 person year. Compared with vegans, hazard ratios of MS for nonvegetarians, pescovegetarians, lactovegetarians were 0.75 (95% CI, 0.64, 0.88), 0.68 (95% CI, 0.55, 0.83) and 0.81 (95% CI, 0.67, 0.97) after adjusting for sex, age, education status, smoking status, drinking status, physical activity at work and leisure, respectively. As for MS components, nonvegetarians and pescovegetarians had 0.72 (95% CI, 0.62, 0.84), 0.70 (95% CI, 0.57, 0.84) times risk of developing low high density lipoprotein cholesterol (HDL-C), while nonvegetarians had 1.16 (95% CI, 1.02, 1.32) times risk of developing high fasting plasma glucose. Our data suggest that the vegan diets did not decrease the risk of metabolic syndrome compared with pescovegetarian, lactovegetarian and nonvegetarian diets in a Taiwanese cohort.     

PKA含量动力学检测方法的研究与建立

目的 建立激肽释放酶原激活剂(prekallikrein activator,PKA)含量的动力学检测方法,并对该方法进行验证.方法 对比不同样品稀释缓冲液的pH、离子强度,各步骤的孵育时间、孵育温度等因素,确定检测方法的最适条件.并对该方法的准确度、专属性、精密度、线性、稳定性和耐用性进行方法学验证.结果 确定以0....     

基于网络药理学的建昌帮姜天麻对偏头痛作用机制研究

目的:基于网络药理学研究姜天麻对偏头痛的作用机制.方法:选取前期姜制天麻前后已确定的20种差异性成分为研究对象,通过Swiss target prediction等数据库,预测这些成分与偏头痛相关靶点之间关系,利用Cytoscape软件构建"药物-化合物-靶点-疾病"的网络图,并进行GO功能和KEGG通路富集分析.结果...     

Twist在大肠癌中的表达及其与临床病理指标的关系

目的探讨肿瘤相关基因Twist表达在大肠癌临床病理诊断中的应用价值。方法应用鼠抗人Twist单克隆抗体采用S-P免疫组织化学方法检测112例不同类型大肠癌组织及40例正常肠粘膜组织中Twist的表达并与临床病理指标比较。结果在112例大肠癌组织中,Twist基因阳性表达78例;在正常组织中其阳性表达为15例,两者比较具有显著统计学差异(χ2=11.21,p=0.001);进一步综合临床病理资料统计分析,Twist在大肠癌组织中表达与肿瘤的分化程度、肿瘤浸润、淋巴结转移、Duke’s分期有关(p值分别为0.008、0.017、0.044、0.011),均有显著差异;而与病人年龄、性别无关(p值为0.286、0.887)。结论Twist基因表达检测能较好的判断大肠癌肿瘤分化程度、浸润、淋巴结转移等,在大肠癌诊断中作用明确,对临床病理学诊断有明确的指导作用。     

熟地多糖口服液配合化疗治疗血液肿瘤的临床观察

目的:观察熟地多糖口服液(RGP)对化疗药物致外周血象的影响临床研究。将48例病人随机分为两组,分为熟地多糖口服液治疗组及对照组,分别在化疗期14天内每周查血象一次。结果:RGP可对抗环磷酰胺所致小鼠WBC下降及对抗临床化疗时WBC下降,对骨髓有明显保护作用。