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71.
慢性肾功能衰竭中医证型标准化研究探讨 总被引:21,自引:0,他引:21
本文对2次全国性慢性肾衰中医辨证分型标准进行了分析和总结,并按现行慢性肾衰辨证分型方案对444例患者进行证候学研究,列出了慢性肾衰中出现率高且具有鉴别诊断价值的症状及体征,并发现慢性肾衰尿毒症患者其气血阴阳虚损的积分值明显高于其它各期,提出现行方案的不足之处及有待改进的探讨意见 相似文献
72.
对某化纤厂99名长期接触低浓度二硫化碳(CS2)作业工人和28名同厂非CS2作业工人的血脂进行流行病学横断面调查。结果发现:除接触组脂蛋白(a)[Lp(a)]浓度明显高于对照组外,其它血脂指标差别均无统计学意义;进一步通过多元逐步回归分析发现,长期低浓度CS2接触对Lp(a)的影响最大,二者呈正相关(r=0.43,P<0.01)。提示Lp(a)可能在CS2致脂质代谢障碍毒作用机制中起着重要作用。 相似文献
73.
新生儿血镉浓度的性别差异 总被引:1,自引:0,他引:1
金属镉对生物体造成的危害早已被人们所认识。1955年日本富山神通川下游出现的“痛痛病”即是与人们食入含镉量过高的食物有关。据该地流行病学调查,患者多为40岁以上的妇女[1,2],说明女性对镉的危害性较为敏感。本文取长沙地区的新生儿脐血及母血进行血镉的... 相似文献
74.
The aim of this study was to compare the linear growth of children with cerebral palsy (CP) with that of children without CP. The segmental lengths (humerus, ulna, femur, tibia, and spine), recumbent length, body weight, and bone age of 62 children with CP (age range 2.25 to 14 years, mean 7.13 years) were measured and compared with 68 children without CP (age range 1.50 to 12.67 years, mean 6.73 years). The results show that bone-age delay is common in children with CP (68% with a delay of more than 1 year). The linear growth of children with CP is similar to that of children without CP when bone age is used instead of chronological age. There is a strong correlation between segmental lengths and body height. Hence, this study favours using segmental lengths for estimating height in children with CP and using the comparison group as a reference for this purpose. Nutritional and non-nutritional factors on bone-age delay are discussed. 相似文献
75.
目的 探讨抑那通和缓退瘤联合治疗对正常前列腺,增生的前列腺(BPH)和前列腺癌以及睾丸的作用。方法 对16例接受联合内分泌治疗至少3个月且有治疗前后病理资料的前列腺癌患者的标本进行了系统的病理学检查。对内分泌治疗后的睾丸标本与同龄未接受治疗的进行对照研究。结果 14例内分泌治疗后的前列腺标本2例未见残存癌灶,9例对治疗有明显的反应;3例对治疗反应差,治疗并未降低前列腺癌的病理分期。3例内分泌治疗后 相似文献
76.
长期饮酒对男性生殖系统功能影响 总被引:1,自引:0,他引:1
目的探讨饮酒对男性生殖系统的损害及其机理。方法选择45名男性饮酒者和9名慢性酒精中毒者为研究对象,以15名不吸烟不接触毒物的男性为对照组。结果长期大量饮酒和酒精中毒者血清中T和CS水平下降,而LH和FSH水平升高;精浆和精子中LDH,LDH-x和G-6PD活力下降,以LDH-x下降为敏感;精子数量和活动精子年均降低,精子畸形率及异常精液检出率均升高。上述各指标与对照组比较差异均有高度显著性(P<0.01)。结论长期饮酒可损害男性生殖系统功能。 相似文献
77.
Xanthine oxidase is a key enzyme associated with the incidence of hyperuricemia-related disorders. Repeated chromatography of the enzyme inhibitory part of the water extract of the twigs and leaves of Brandisia hancei (Scrophulariaceae) gave a flavone luteolin, an iridoid glycoside mussaenoside, two beta-sitosterol glycosides daucosterol and beta-sitosterol gentiobioside, and five phenylethanoids arenarioside, brandioside, acteoside, 2'-O-acetylacteoside and isoacteoside. Luteolin and isoacteoside inhibited the xanthine oxidase (XO, EC 1.2.3.2) with the IC50 values at 7.83 and 45.48 microM, respectively. Isoacteoside was found to be the first phenylethanoid that decreased substantially the formation of uric acid by inhibiting competitively xanthine oxidase (Ki value: 10.08 microM). Furthermore, the study suggested that the caffeoylation of the 6'-hydroxyl group of the phenylethanoids was essential for the enzyme inhibitory action. 相似文献
78.
A series of 4-amino Capsaicin analogs 15, 17 and 19 were prepared to investigate the bioisosteric effect of 4-amino group, and all these compounds exhibited moderate or weak potency from their analgesic test. From our previous results and others, 4-hydroxyl group as well as 3-methoxy substituent could be crucial for high analgesic activity. This biological result also shows that the activity is sensitive to alkyl chain length in hydrophobic region and the phenylacetic amides 19 are more active than the corresponding urea derivatives 17. 相似文献
79.
The application of Ion chromatographic method for bioavailability and stability test of iron preparations 总被引:1,自引:0,他引:1
Young -Ok Kim Hye -Joo Chung Hak -Soo Kong Don -Woong Choi Dae -Hyun Cho 《Archives of pharmacal research》1999,22(3):288-293
Postabsorptive serum iron level was determined after oral administration of the compounds to human. In serum and whole blood, Fe3+ was measured by ion chromatography (IC) using a pyridine-2,6-dicarboxylic acid (PDCA) as an eluent. The serum sample solutions were pretreated with I N HCI and 50% TCA. The whole blood sample solutions were treated with 3 N HCI for 30 min at 125 degrees C. The limit of detection (LOD) of the IC technique is 0.2 microM for Fe2- and 0.1 microM for Fe3+. The area under concentration (AUC) can be obtained by the above analytical condition. In addition, to compare the stability of Fe2+ to that of Fe3+ in pharmaceutical preparations, accelerated stability test was carried out. After storing the samples under 40 degrees C, 75%RH in light-resistant container for various time intervals, the contents of iron of different valencies were determined separately by the IC technique and the change and/or the interchange of among those iron species in preparations was investigated. Iron raw materials are stable, but Fe2+ in Fe3+ source materials was slightly converted to Fe3+ by oxidation. Fe2+ in Fe3+ source raw materials and Fe3+ in Fe2+ raw materials are determined as impurities. Therefore, IC technique is found to be an appropriate method for comparative evaluation of dissimilar bioavailability of Fe2+ and Fe3+, stability of Fe2+ and Fe3+ raw materials and preparations. 相似文献
80.
孔庆玺 《云南中医学院学报》1992,15(1):1-3
吴鞠通《温病条辨·解儿难》对疳疾的论治文短义深,所提治疳九妙法蕴藏着深奥的学术思想。本文从脾胃学说、升降出入学说、营卫学说等方面进行了阐发,以期能发掘其学术渊薮,指导学术研究及临床实践。 相似文献