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991.
Di Cui Lei Du Wei Yu Boning Cai Lingling Meng Jun Yang Yanrong Luo Jing Chen Dr. Lin Ma 《Radiology and oncology》2022,56(2):216
BackgroundOur previous study showed that two different regimens of moderate hypofractionated radiotherapy (HFRT) delivered with helical tomotherapy (HT) are well tolerated in older prostate cancer patients. We provide a longterm efficacy and toxicity after > 7 years of follow-up.Patients and methodsThe study recruited 33 patients from February 2009 to July 2011 (76 Gy/34F; Group-1); and 34 from July 2011 to February 2014 (71.6 Gy/28F; 50.4 Gy/25F for the risk of pelvic lymph nodes involvement (LNI) >15%; Group-2). The primary outcomes were biochemical failure (BF), biochemical failure and clinical disease failure (BCDF), progression-free survival (PFS), overall survival (OS), late genitourinary (GU) and gastrointestinal (GI) toxicity.ResultsThe average ages of two groups were 80 and 77 years and the proportions of patients with LNI > 15% were 69.7% and 73.5%, respectively. At the final follow-up in February 2020, 27.3% and 20.6% cases experienced BF, with a median time until BF of 3.3 years. A total of 38.8% patients reached primary endpoints, in which 18 deaths were reported BCDF events (45.5% vs. 32.4%, p = 0.271). There was no significant difference in 7-year PFS (68.6% vs. 74.8%, p = 0.591), BCDF (45.5% vs. 32.4%, p = 0.271) and OS (71.9% vs. 87.5%, p = 0.376) for full set analysis and for subgroup analysis (all p > 0.05). The incidence of grade ≥ 2 late GU (6.2% vs. 6.3%, p = 0.127) and GI toxicities (9.4% vs. 15.6%, p = 0.554) was comparable.ConclusionsIn older patients with localized prostate cancer, two moderate hypofractionated regimens were all well tolerated with similar, mild late toxicities and satisfactory survival, without necessity of prophylactic pelvic node irradiation.Key words: helical tomotherapy, radiation dose hypofractionation, progression-free survival, follow-up studies, prostatic neoplasms, adenocarcinoma 相似文献
992.
目的:对覆盖义齿的基牙进行短期临床观察。方法:对30例覆盖义齿修复患者半年及1年后回访观察。结果:下颌基牙及非银汞充填覆盖基牙更易存积菌斑及结石,并出现牙龈问题。结论:对于能保持良好口腔卫生的患者,覆盖义齿是一种较好的选择。 相似文献
993.
994.
Haixia Long Ming Fan Qiaojun Li Xuhua Yang Yujiao Huang Xinli Xu Ji Ma Jie Xiao Tianzi Jiang 《Human brain mapping》2022,43(9):2923
Aggression is a common and complex social behavior that is associated with violence and mental diseases. Although sex differences were observed in aggression, the neural mechanism for the effect of sex on aggression behaviors remains unclear, especially in specific subscales of aggression. In this study, we investigated the effects of sex on aggression subscales, gray matter volume (GMV), and functional connectivity (FC) of each insula subregion as well as the correlation of aggression subscales with GMV and FC. This study found that sex significantly influenced (a) physical aggression, anger, and hostility; (b) the GMV of all insula subregions; and (c) the FC of the dorsal agranular insula (dIa), dorsal dysgranular insula (dId), and ventral dysgranular and granular insula (vId_vIg). Additionally, mediation analysis revealed that the GMV of bilateral dIa mediates the association between sex and physical aggression, and left dId–left medial orbital superior frontal gyrus FC mediates the relationship between sex and anger. These findings revealed the neural mechanism underlying the sex differences in aggression subscales and the important role of the insula in aggression differences between males and females. This finding could potentially explain sexual dimorphism in neuropsychiatric disorders and improve dysregulated aggressive behavior. 相似文献
995.
996.
Follicular dendritic cell sarcoma (FDCS) of the nasopharynx is a rare malignant tumor that has been described in only a few case reports, and its differential diagnoses include diverse clinicopathologic entities. FDCS is often initially misdiagnosed, especially when examining small biopsy specimens. We herein report a case of FDCS arising in the nasopharynx that was initially misdiagnosed as a nerve sheath tumor. A 44-year-old woman presented with persistent obstruction of the left nasal cavity and underwent an excisional biopsy. The specimen demonstrated morphologic and immunohistochemical features of FDCS. In situ hybridization for Epstein–Barr virus-encoded RNA was negative. The patient was treated with chemotherapy and radiotherapy. The sarcoma recurred near the original site more than 3 years after the initial treatment and was completely resected. At the time of this writing, the patient had remained disease-free for 1 year after resection. This case is being reported to improve the clinical recognition of FDCS. 相似文献
997.
5-Hydroxymethylfurfural (HMF) is a valuable platform chemical derived from biomass and lots of research focuses on the synthesis of HMF from fructose and glucose. Herein, conversion of bio-carbohydrates to 5-hydroxymethylfurfural (HMF) was studied in the three-component deep eutectic solvent (DES) system, which was composed of choline chloride (ChCl), boric acid and substrates such as fructose, glucose and sucrose. Bio-carbohydrates handled under typical reaction conditions gave satisfactory conversion (44% for fructose and 31% for glucose) and yield of HMF (35% for fructose and 21% for glucose) in 1 h. Moreover, owing to the benefits of DES, the initial substrate content could be higher and the reaction temperature could be reduced, thus side reactions were effectively avoided and the selectivity of HMF was better (ranging from 79% to 100% for fructose and from 65% to 100% for glucose). We believe this method could provide a promising alternative for conversion of bio-carbohydrates to HMF and a better utilization of biomass.The conversion process of fructose and glucose in the three-component DES system. Substrates such as fructose, glucose and sucrose treated with this DES system could convert to HMF in a satisfactory yield and selectivity. 相似文献
998.
999.
1000.
Miller-Fisher综合征和Bickerstaff脑干脑炎的临床特点及鉴别诊断 总被引:4,自引:0,他引:4
目的 探讨Miller-Fisher综合征(MFS)和Bickerstaff脑干脑炎(BBE)的临床特点及鉴别诊断.方法 回顾性分析12例MFS和15例BBE患者的临床资料.结果 MFS组表现为视物成双12例,瞳孔对光反射消失3例,周围性面瘫7例,饮水呛咳1例,四肢无力6例,感觉障碍4例,共济失调10例;BBE组表现为视物成双11例,中枢性面瘫4例,耳鸣4例,饮水呛咳6例,四肢无力10例,感觉障碍2例,共济失调10例,嗜睡或昏迷5例,病理征9例.脑脊液检查MFS组和BBE组各有10例表现为蛋白升高;MFS组脑脊液白细胞升高2例,BBE组6例.MFS组3例、BBE组1例肌电图出现神经源性损害.BBE组有6例CT或MRI检查异常,主要部位为脑干、丘脑等.两组患者治疗后预后良好.结论 MFS和BBE有相似特点,临床表现可以相互重叠,提示这两种疾病密切相关并形成一个连续的疾病谱;主要鉴别点是BBE患者可以有意识障碍、病理征和影像学异常. 相似文献