皮肤感觉神经与创面组织相互作用的研究

【摘要】皮肤感觉神经对创面愈合过程中的炎性介质反应、新血管形成、肉芽增生和愈合后重塑均有重要调控作用,同时创面的组织细胞又能反作用于皮肤感觉神经。对皮肤感觉神经的合理干预能够有效改善创面的转归。     

睡眠呼吸暂停综合征患者的睡眠分期算法研究

针对可穿戴睡眠监测缺乏有效的自动睡眠分期和睡眠质量评价方法这一问题,提出一种适用于睡眠呼吸暂停综合征患者的自动睡眠分期方法。通过心电图R-R间期序列,分别得到心率变异性、呼吸幅度变异性和呼吸率变异性信号。以此为基础,提取时域、频域及非线性特征共55个。利用门控循环单元网络,分别构建清醒-睡眠二分类、清醒-快速眼动-非快速眼动睡眠三分类、清醒-快速眼动-浅睡-慢波睡眠四分类、清醒-快速眼动-非快速眼动Ⅰ-Ⅱ-Ⅲ期五分类等共4个不同分类粒度的睡眠分期模型;采用损失函数类别加权方法,有效降低数据非平衡对分期结果的影响。验证数据来自SHRS数据库的274例患者。借助准确率、Cohen's Kappa系数和睡眠结构指标对该睡眠分期方法进行性能评价。结果表明4个分类器的准确率分别为85.06%、75.44%、63.80%、62.13%,Cohen's Kappa系数达到了0.54、0.49、0.41、0.41,睡眠结构分析评估与临床结果之间的差异无统计学意义。所提出的方法基本满足睡眠质量评估的需求,适用于可穿戴睡眠监测应用。     

脑卒中患者血浆神经降压素水平及其动态变化

目的:观察脑出血、脑梗死、蛛网膜下腔出血患者血浆神经降压素(neurotensin,NT)水平改变及其动态变化,探讨NT参与各型脑卒中及其伴发病中的病理生理机制及对功能预后评估的意义。方法:2002-03/2003-09,实验在济南长城医院神经内科、山东大学附属第二医院神经内科、山东省立医院、山东大学齐鲁医院神经内科与泰山医学院微循环研究所完成。选择脑卒中138例,其中脑出血组46例,脑梗死组62例,蛛网膜下腔出血组30例。病例依病情轻重、病灶大小、病程、伴发病积分、有无高血压史等分组,选择28例健康查体者作为对照组。用放免法检测血浆NT浓度。结果:脑梗死组NT水平(467.31±363.42)ng/L显著高于对照组(76.54±59.53)ng/L(t=4.638,P<0.0001),于发病后24h内显著升高(228.10±123.13)ng/L,4～7d达高峰(648.01±337.38)ng/L,8～15d开始下降(525.67±264.11)ng/L,15d后仍在较高水平(392.57±262.35)ng/L;重型(762.91±446.0)ng/L与大灶组(404.39±206.49)ng/L显著高于轻型(153.86±130.47)ng/L与小灶组(200.27±137.64)ng/L(P<0.01),伴发病积分≥6分组NT水平(623.11±377.97)ng/L显著高于<6分组(236.74±132.22)ng/L(t=3.506,P<0.001),高血糖组NT水平(673.26±331.00)ng/L显著高于正常血糖组(328.16±216.69)ng/L(t=     

Preparation of Indapamide slow-release pellets

During the process of developing a slow-release formulation of indapamide, researchers created a drug-containing pellet coated with Eudragit RS100 (Rohm GMbH & Co. KG, Darmstadt, Germany) to control the rate at which the drug was released. The two main variables were the agglomerants used in the pellet preparation and the amount of Eudragit RS100 used to coat them. The optimal outcome was indicated by the greatest number of drug-containing pellets recovered through an 18- to 24-mesh sieve and a satisfactory 24-hour release curve. The kinetics of dissolution fit the Higuchi kinetics model. Stability tests of the drug pellets showed no notable changes in the rate of drug release, related substances (mean byproducts or impurities from interactions or decompositions), and drug content.     

护士工作环境的研究进展

护理工作是一种高风险的工作，特别是急诊护理，更是风险中的风险。在急救医学和现代社会高度发展的今天，为提高急救护理质量。将风险减至最低限度实属必要。     

住院病人护理需求的质性研究

目的 深入了解住院病人存在的护理需求,为护士有针对性的护理服务措施提供依据.方法 应用Maslow的需要层次理论为框架访谈了江西省某医院11位住院病人和8位临床护士.结果 经过分析了解到病人在住院期间可能存在的59项护理需求和病人对医院工作的一些要求.结论 医院各部门和护士要重视病人的护理需求,使病人在住院期间得到高品质的护理服务.     

Primary intravascular large B cell lymphoma of the endometrium

Primary intravascular large B cell lymphoma (IVLBCL) of the endometrium is extremely rare. So far, only 5 cases have been reported in the English literature. We now report a new case of endometrial IVLBCL which exhibited distinct clinicopathological characteristics and meaningful laboratory tests, and also review the literature. A 66-year-old woman showed symptoms of chronic cough and choking sensation for 4 months. Following three days of vaginal bleeding she presented for examination and diagnosis. The percentage of monocytes in the blood was double that of normal levels. There was a polyp in the endometrium, which showed a number of medium–large lymphoid cells in dilated capillaries. Immunohistochemically, the lymphoid cells were immunoreactive to CD20, CD79a, Mum-1 and Foxp-1 with 85% cells immunoreactive to Ki-67. IVLBCL of the endometrium is rare and the clinical diagnosis is very difficult. Unexplained fever of old people and abnormal laboratory tests such as obvious abnormal monocyte distribution in the blood should alert the clinical doctor to the possibility of IVLBCL. A correct diagnosis mainly depends on pathological tests and immunohistochemical labeling. The prognosis of IVLBCL is poor and few patients survive longer than one year.     

Resolvin D1 Alleviates the Lung Ischemia Reperfusion Injury via Complement,Immunoglobulin, TLR4, and Inflammatory Factors in Rats

Lung ischemia-reperfusion injury (LIRI) is still an unsolved medical issue, which negatively affects the prognosis of many lung diseases. The aim of this study is to determine the effects of RvD1 on LIRI and the potential mechanisms involved. The results revealed that the levels of complement, immunoglobulin, cytokines, sICAM-1, MPO, MDA, CINC-1, MCP-1, ANXA-1, TLR4, NF-κBp65, apoptosis index, and pulmonary permeability index were increased, whereas the levels of SOD, GSH-PX activity, and oxygenation index were decreased in rats with LIRI. Except for ANXA-1, these responses induced by LIRI were significantly inhibited by RvD1 treatment. In addition, LIRI-induced structure damages of lung tissues were also alleviated by RvD1 as shown by H&E staining and transmission electron microscopy. The results suggest that RvD1 may play an important role in protection of LIRI via inhibition of complement, immunoglobulin, and neutrophil activation; down-regulation of TLR4/NF-κB; and the expression of a variety of inflammatory factors.