全文获取类型
收费全文 | 57727篇 |
免费 | 4695篇 |
国内免费 | 1882篇 |
专业分类
耳鼻咽喉 | 658篇 |
儿科学 | 684篇 |
妇产科学 | 1123篇 |
基础医学 | 8716篇 |
口腔科学 | 1465篇 |
临床医学 | 5027篇 |
内科学 | 10872篇 |
皮肤病学 | 1073篇 |
神经病学 | 4020篇 |
特种医学 | 1850篇 |
外国民族医学 | 6篇 |
外科学 | 8008篇 |
综合类 | 4905篇 |
现状与发展 | 1篇 |
一般理论 | 5篇 |
预防医学 | 3298篇 |
眼科学 | 1518篇 |
药学 | 5351篇 |
1篇 | |
中国医学 | 1065篇 |
肿瘤学 | 4658篇 |
出版年
2023年 | 304篇 |
2022年 | 523篇 |
2021年 | 833篇 |
2020年 | 528篇 |
2019年 | 805篇 |
2018年 | 1305篇 |
2017年 | 1030篇 |
2016年 | 1025篇 |
2015年 | 1207篇 |
2014年 | 1549篇 |
2013年 | 1869篇 |
2012年 | 2535篇 |
2011年 | 2463篇 |
2010年 | 1498篇 |
2009年 | 1431篇 |
2008年 | 2101篇 |
2007年 | 2266篇 |
2006年 | 2103篇 |
2005年 | 1777篇 |
2004年 | 1550篇 |
2003年 | 1525篇 |
2002年 | 1415篇 |
2001年 | 4747篇 |
2000年 | 4678篇 |
1999年 | 4024篇 |
1998年 | 1447篇 |
1997年 | 1070篇 |
1996年 | 668篇 |
1995年 | 568篇 |
1994年 | 498篇 |
1993年 | 435篇 |
1992年 | 1960篇 |
1991年 | 1703篇 |
1990年 | 1554篇 |
1989年 | 1521篇 |
1988年 | 1319篇 |
1987年 | 1208篇 |
1986年 | 1083篇 |
1985年 | 905篇 |
1984年 | 597篇 |
1983年 | 474篇 |
1982年 | 252篇 |
1981年 | 185篇 |
1980年 | 142篇 |
1979年 | 280篇 |
1978年 | 78篇 |
1974年 | 76篇 |
1973年 | 98篇 |
1972年 | 72篇 |
1969年 | 69篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
Parallel enzyme‐linked immunosorbent assay screening for human immunodeficiency virus among blood donors in five Chinese blood centres: a retrospective analysis 下载免费PDF全文
3.
4.
5.
Phytonutrients extracted from natural resources are receiving much attention among researchers due to their highly antioxidative characteristics which prevent several degenerative diseases including cardiovascular diseases and cancers. These nutraceutical compounds can be used in food, pharmaceutical and cosmetic products as natural antioxidants, preservatives, colourants and functional foods. Huge volume of food wastes are generated from the processing industry and these low-value food residues are rich in various phytonutrients worth recovering. This approach of valorisation reduces the generation of food wastes and is cost-effective considering the cheap feedstock, reduced waste management expenses and high market value of extracted compounds. In light of the health and safety risks posed by commonly used organic extraction solvents derived from the petrochemical industry, there is a need to recover the phytonutrients using green, sustainable and efficient solvents that are safe for human consumption. This work discusses ethyl lactate as a safe, green, efficient and potentially cheap solvent to recover phytonutrients from fruit and vegetable by-products. Ethyl lactate is compared with other organic solvents commonly used from the aspects of safety, environmental impacts and efficiency. Current challenges when employing ethyl lactate are also discussed. 相似文献
6.
7.
Emmi Helle Aldo Córdova-Palomera Tiina Ojala Priyanka Saha Praneetha Potiny Stefan Gustafsson Erik Ingelsson Michael Bamshad Deborah Nickerson Jessica X. Chong University of Washington Center for Mendelian Genomics Euan Ashley James R. Priest 《Genetic epidemiology》2019,43(2):215-226
Loss of function variants in NOTCH1 cause left ventricular outflow tract obstructive defects (LVOTO). However, the risk conferred by rare and noncoding variants in NOTCH1 for LVOTO remains largely uncharacterized. In a cohort of 49 families affected by hypoplastic left heart syndrome, a severe form of LVOTO, we discovered predicted loss of function NOTCH1 variants in 6% of individuals. Rare or low-frequency missense variants were found in 16% of families. To make a quantitative estimate of the genetic risk posed by variants in NOTCH1 for LVOTO, we studied associations of 400 coding and noncoding variants in NOTCH1 in 1,085 cases and 332,788 controls from the UK Biobank. Two rare intronic variants in strong linkage disequilibrium displayed significant association with risk for LVOTO amongst European-ancestry individuals. This result was replicated in an independent analysis of 210 cases and 68,762 controls of non-European and mixed ancestry. In conclusion, carrying rare predicted loss of function variants in NOTCH1 confer significant risk for LVOTO. In addition, the two intronic variants seem to be associated with an increased risk for these defects. Our approach demonstrates the utility of population-based data sets in quantifying the specific risk of individual variants for disease-related phenotypes. 相似文献
8.
Gregory N. Gan 《Expert opinion on investigational drugs》2016,25(10):1153-1166
Introduction: Cancer treatment is moving away from conventional cytotoxic drugs and towards agents that target specific proteins and mechanisms important to cancer development or survival. The Hedgehog Pathway (HhP) is a signal transduction pathway and its constitutive activation is tumorigenic in basal cell carcinoma (BCC). The HhP enables phenotypic flexibility, and channels tumor-stroma interactions. As a result, it is over-expressed in numerous cancers as well as in the tumor microenvironment and may represent a promising therapeutic target.Areas covered: In this article, we review the rationale for targeting HhP and its role as an oncogenic driver, in tumor epithelial-to-mesenchymal transition (EMT), and in the tumor microenvironment and describe the results of preclinical and clinical studies involving HhP inhibitors.Expert opinion: HhP activation plays an important role in both the tumor microenvironment and tumor EMT which can lead to treatment resistance for a number of different malignancies. In addition to standard use in BCC, several HhP inhibitors are in preclinical, early, and mid-stage clinical development for other solid and hematologic malignancies. 相似文献
9.
10.