全文获取类型
收费全文 | 1970篇 |
免费 | 197篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 84篇 |
妇产科学 | 44篇 |
基础医学 | 233篇 |
口腔科学 | 50篇 |
临床医学 | 184篇 |
内科学 | 398篇 |
皮肤病学 | 40篇 |
神经病学 | 196篇 |
特种医学 | 286篇 |
外科学 | 171篇 |
综合类 | 38篇 |
一般理论 | 2篇 |
预防医学 | 241篇 |
眼科学 | 10篇 |
药学 | 72篇 |
中国医学 | 1篇 |
肿瘤学 | 115篇 |
出版年
2021年 | 14篇 |
2018年 | 20篇 |
2017年 | 28篇 |
2016年 | 34篇 |
2015年 | 35篇 |
2014年 | 47篇 |
2013年 | 83篇 |
2012年 | 71篇 |
2011年 | 65篇 |
2010年 | 74篇 |
2009年 | 65篇 |
2008年 | 54篇 |
2007年 | 64篇 |
2006年 | 74篇 |
2005年 | 47篇 |
2004年 | 58篇 |
2003年 | 64篇 |
2002年 | 44篇 |
2001年 | 35篇 |
2000年 | 24篇 |
1999年 | 32篇 |
1998年 | 61篇 |
1997年 | 81篇 |
1996年 | 60篇 |
1995年 | 51篇 |
1994年 | 58篇 |
1993年 | 63篇 |
1992年 | 20篇 |
1991年 | 24篇 |
1990年 | 22篇 |
1989年 | 50篇 |
1988年 | 57篇 |
1987年 | 45篇 |
1986年 | 38篇 |
1985年 | 38篇 |
1984年 | 19篇 |
1983年 | 33篇 |
1982年 | 28篇 |
1981年 | 23篇 |
1980年 | 30篇 |
1979年 | 17篇 |
1978年 | 16篇 |
1977年 | 20篇 |
1976年 | 24篇 |
1975年 | 28篇 |
1973年 | 15篇 |
1971年 | 15篇 |
1970年 | 30篇 |
1969年 | 30篇 |
1968年 | 34篇 |
排序方式: 共有2170条查询结果,搜索用时 15 毫秒
81.
Stephen F. Hall A. Fitzgerald O'Connor C. H. Thakkar I. G. Wylie A. W. Morrison 《The Laryngoscope》1983,93(12):1551-1553
The revival of endolymphatic sac surgery has led to many investigations in Meniere's disease, including lateral tomography of the periaqueductal pneumatization. We radiologically assessed a series of Meniere's patients and a control group, and found hypocellularity to be more common in Meniere's disease as the literature has stated. However, we found this finding bilaterally in patients with unilateral disease. Our assessment of this information in regard to the etiology and treatment of Meniere's disease is presented. 相似文献
82.
83.
84.
85.
Martínez-Rodríguez J Iranzo A Santamaría J Genís D Molins A Silva Y Meléndez R 《Neurología (Barcelona, Spain)》2002,17(2):113-116
Introduction: Cataplexy is one of the main narcoleptic symptoms and is characterized by sudden loss of muscle tone triggered by emotional stimuli while consciousness is mantained. Clomipramine is an effective treatment of cataplexy. Cataplexy that occurs repeatedly for hours or days is referred to as status cataplecticus.Patients: We report three adults with narcolepsy in whom cataplexy was chronically and effectively treated with clomipramine (75-150 mg/day). For diverse reasons, these three patients had an abrupt withdrawal of clomipramine, and after 2-9 days patients showed an invalidant status cataplecticus characterized by a marked increase of the frequency, duration and severity of their cataplectic attacks that were now elicited by mild emotional stimuli. After introduction of anticataplectic agents (clomipramine in two patients and fluoxetine in one patient), status cataplecticus was resolved in less than a week.Conclusion: In patients with narcolepsy, abrupt withdrawal of chronic treatment with clomipramine may be associated with status cataplecticus. This condition may be resolved with the reintroduction of anticataplectic agents. 相似文献
86.
背景:阿德福韦双酯(ADV) 是一种有效治疗野生型和耐拉米夫定乙肝病毒(HBV)的核苷酸类药物。在使用核苷酸类药物治疗慢性乙肝时,当治疗时间为 48、96、144周时,耐ADV变异体出现的累积发生率分别为0、 0.8-3%和0-5.9%。目的:研究67例对拉米夫定耐药且接受ADV治疗的慢性乙肝患者耐ADV病毒变异体的表型和基因型特点。方法:HBV DNA含量采用实时定量PCR技术。ADV变异体检测采用基质辅助激光解吸电离/飞行时间质谱为基础的基因分型 相似文献
87.
Wylie ME Miller MD Shear MK Little JT Mulsant BH Pollock BG Reynolds CF 《Journal of geriatric psychiatry and neurology》2000,13(1):43-48
The authors present data from an open trial of fluvoxamine (median daily dosage: 200 mg) in the treatment of generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder in 19 older outpatients (mean age = 66.8). Of the 12 subjects completing the 21-week trial, 8 achieved a good response (50% reduction in symptom measures) and 7 were rated as much or very much improved. Fluvoxamine pharmacotherapy also had a significant effect in reducing comorbid depressive symptoms and in increasing levels of functioning. These data support the effectiveness of fluvoxamine in older subjects with anxiety disorders (particularly generalized anxiety disorder) and warrant further double-blind, placebo-controlled evaluation. 相似文献
88.
Attributions regarding the nature, cause, and best treatment of mental health problems were examined in a total of 563 adults with serious mental illness from four ethnocultural groups, 185 family members, and 43 mental health practitioners. Attributions agreed in many areas, such as stress as a cause, and medical intervention and counseling as best treatment. Differences were found between the practitioner and other groups in attributions regarding the senses in the nature of mental illness, and in drugs and alcohol as a cause. The role of ethnicity was examined and treatment implications discussed. 相似文献
89.
Resistance of Copenhagen rats to chemical induction of glutathione S- transferase 7-7-positive liver foci 总被引:2,自引:0,他引:2
Copenhagen (Cop) rats are completely resistant to the chemical induction of
mammary adenocarcinomas, but their susceptibility to hepatocarcinogenesis
is virtually unknown. Rat liver is a well- characterized and easily
manipulated tissue in which to study carcinogenesis. Therefore, if Cop rats
are resistant to hepatocarcinogenesis, studies into resistance mechanisms
may be feasible. Male Cop and F344 rats, 7-8 weeks old, were initiated
using either N-nitrosodiethylamine (DEN) (200 mg/kg, i.p.) or a two-thirds
partial hepatectomy (PH) followed by N-methyl-N-nitrosourea (MNU) (60
mg/kg, i.p.). The rats were then promoted using a modified resistant
hepatocyte (RH) protocol (a combination of four doses of 2-
acetylaminofluorene (2-AAF) and a single dose of CCl4 that provides a
selective mitotic stimulus for initiated cells). Six weeks after initiation
the rats were killed and liver sections were stained for glutathione
S-transferase 7-7 (GST 7-7), a marker for putative preneoplastic
hepatocytes. Cop rats were found to be highly resistant, having a
approximately 9- and approximately 27-fold smaller percentage of liver area
occupied by GST 7-7-positive foci than susceptible F344 rats following
initiation by DEN and MNU respectively. Furthermore, gross liver nodules
did not form in any of the Cop rats, whereas all F344 rat livers contained
nodules. Hepatic necrosis caused by DEN during initiation, and CCl4 during
promotion is necessary to stimulate compensatory hepatocyte division. We
demonstrated that these agents do indeed increase serum transaminase levels
and produce histologic evidence of necrosis in Cop rats. In order for liver
foci to grow rapidly in the RH protocol, the surrounding normal hepatocytes
must be mito-inhibited by 2-AAF. We found that the degree of
mito-inhibition of normal hepatocytes by 2-AAF is the same in Cop and F344
rats. These results show that the Cop rat is highly resistant to the
chemical induction of putative preneoplastic liver foci and nodules.
相似文献
90.