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排序方式: 共有885条查询结果,搜索用时 15 毫秒
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Lund SS Tamow L Stehouwer CD 《药品评价》2008,5(8):380-380
在2型糖尿病患者中,反映炎症和内皮功能障碍的生物标志已经与心血管疾病和代谢调节联系起来。二甲双胍和促胰岛素分泌剂被证明有相同的抗高血糖作用。此研究比较了二甲双胍和促胰岛素分泌剂瑞格列奈在非肥胖的2型糖尿病患者的心血管疾病生物标志上的效能。 相似文献
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J F Knutson H A Schartz B J Gantz R S Tyler J V Hinrichs G Woodworth 《The Annals of otology, rhinology, and laryngology》1991,100(11):877-882
Consecutive recipients of multichannel cochlear implants participated in preimplant as well as 9-month and 18-month psychological evaluations. Before receiving a cochlear implant, psychological tests indicated that the implant recipients were more depressed, suspicious, socially isolated, lonely, and socially anxious than was the general population. After 18 months of implant use, there was a significant reduction in depression, loneliness, social anxiety, social isolation, and suspiciousness. These changes in psychological state did not correlate with improved performance on audiological measures. The data suggest that although cochlear implants can have a positive effect on the emotional and behavioral status of persons with acquired postlingual profound deafness, the psychological outcome of implants is not simply a function of the audiological benefit assessed with standardized speech-based audiological tests. 相似文献
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McAuliffe WE LaBrie R Woodworth R Zhang C Dunn RP 《The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions》2003,12(2):101-121
This study estimated the adequacy of state substance abuse treatment rates relative to treatment needs. The investigators created composite drug and alcohol treatment need indexes from explicit-mention mortality and substance-defined arrest rates. The indexes were reliable and had evidence of construct validity, but alternative population-at-risk and survey-based need measures did not fair as well. States varied substantially in per capita alcohol and drug treatment needs, although the two did not correlate with each other. While the need indexes correlated significantly with state treatment rates, the adequacy of state treatment rates varied greatly. States with the largest treatment gaps were in the South, Southwest, and northern plains and mountain regions. The failure of the Block Grant formula to reflect the needs of rural states with high-risk minority populations may contribute to disparities in access to services. 相似文献
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Management of paranasal sinus malignancy 总被引:1,自引:0,他引:1
Day TA Beas RA Schlosser RJ Woodworth BA Barredo J Sharma AK Gillespie MB 《Current treatment options in oncology》2005,6(1):3-18
Opinion statement Malignancies of the nasal cavity and paranasal sinuses represent a wide spectrum of histologies, tissues
of origin, and anatomic primary sites. The inherent difficulty in generalizing treatment approaches is obvious, given the
numerous variables associated with the broadly-based term, paranasal sinus malignancy (PNSCa). Nevertheless, the majority
of epithelial and salivary malignancies of this region (ie, squamous cell carcinoma, adenocarcinoma, adenoid cystic carcinoma, sinonasal undifferentiated carcinoma, and esthesioneuroblastoma)
require surgical intervention as part of any treatment regimen. Recent trends have broadened the indications for chemotherapeutic
and radiotherapeutic options in the management of advanced PNSCa. Nonepithelial malignancies, including the wide variety of
sarcomas arising in this region, most commonly require multimodality treatment including chemotherapy, radiation, and/or surgery
for definitive treatment. Moreover, the proximity of the nasal cavity and paranasal sinuses to structures including the orbit,
dura, brain, cranial nerves, and carotid arteries mandates careful radiologic and neurologic evaluations throughout the course
of the disease. Surgical advances now permit complex tumor removal and reconstruction surrounding these structures resulting
in functional and cosmetic improvements when compared to earlier techniques. However, additional clinical trials are necessary
to systematically evaluate the locoregional control, organ-preservation strategies, and survival related to the variety of
treatments currently available. 相似文献
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Independent predictors of morbidity after image-guided stereotactic brain biopsy: a risk assessment of 270 cases 总被引:7,自引:0,他引:7
McGirt MJ Woodworth GF Coon AL Frazier JM Amundson E Garonzik I Olivi A Weingart JD 《Journal of neurosurgery》2005,102(5):897-901
OBJECT: Image-guided stereotactic brain biopsy is associated with transient and permanent incidences of morbidity in 9 and 4.5% of patients, respectively. The goal of this study was to perform a critical analysis of risk factors predictive of an enhanced operative risk in frame-based and frameless stereotactic brain biopsy. METHODS: The authors reviewed the clinical and neuroimaging records of 270 patients who underwent consecutive frame-based and frameless image-guided stereotactic brain biopsies. The association between preoperative variables and biopsy-related morbidity was assessed by performing a multivariate logistic regression analysis. Transient and permanent stereotactic biopsy-related morbidity was observed in 23 (9%) and 13 (5%) patients, respectively. A hematoma occurred at the biopsy site in 25 patients (9%); 10 patients (4%) were symptomatic. Diabetes mellitus (odds ratio [OR] 3.73, 95% confidence interval [CI] 1.37-10.17, p = 0.01), thalamic lesions (OR 4.06, 95% CI 1.63-10.11, p = 0.002), and basal ganglia lesions (OR 3.29, 95% CI 1.05-10.25, p = 0.04) were in'dependent risk factors for morbidity. In diabetic patients, a serum level of glucose that was greater than 200 mg/dl on the day of biopsy had a 100% positive predictive value and a glucose level lower than 200 mg/dl on the same day had a 95% negative predictive value for biopsy-related morbidity. Pontine biopsy was not a risk factor for morbidity. Only two (4%) of 45 patients who had epilepsy before the biopsy experienced seizures postoperatively. The creation of more than one needle trajectory increased the incidence of neurological deficits from 17 to 44% when associated with the treatment of deep lesions (those in the basal ganglia or thalamus; p = 0.05), but was not associated with morbidity when associated with the treatment of cortex lesions. CONCLUSIONS: Basal ganglia lesions, thalamic lesions, and patients with diabetes were independent risk factors for biopsy-associated morbidity. Hyperglycemia on the day of biopsy predicted morbidity in the diabetic population. Epilepsy did not predispose to biopsy-associated seizure. For deep-seated lesions, increasing the number of biopsy samples along an established track rather than performing a second trajectory may minimize the incidence of morbidity. Close perioperative observation of glucose levels may be warranted. 相似文献
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