全文获取类型
收费全文 | 381篇 |
免费 | 18篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 12篇 |
妇产科学 | 6篇 |
基础医学 | 33篇 |
口腔科学 | 23篇 |
临床医学 | 44篇 |
内科学 | 62篇 |
皮肤病学 | 2篇 |
神经病学 | 22篇 |
特种医学 | 70篇 |
外科学 | 21篇 |
综合类 | 3篇 |
预防医学 | 28篇 |
眼科学 | 1篇 |
药学 | 11篇 |
肿瘤学 | 62篇 |
出版年
2021年 | 3篇 |
2020年 | 3篇 |
2019年 | 6篇 |
2018年 | 7篇 |
2017年 | 8篇 |
2016年 | 4篇 |
2015年 | 5篇 |
2014年 | 10篇 |
2013年 | 19篇 |
2012年 | 16篇 |
2011年 | 17篇 |
2010年 | 9篇 |
2009年 | 8篇 |
2008年 | 15篇 |
2007年 | 10篇 |
2006年 | 10篇 |
2005年 | 19篇 |
2004年 | 12篇 |
2003年 | 6篇 |
2002年 | 13篇 |
2001年 | 5篇 |
2000年 | 7篇 |
1999年 | 4篇 |
1998年 | 7篇 |
1997年 | 14篇 |
1996年 | 12篇 |
1995年 | 15篇 |
1994年 | 14篇 |
1993年 | 20篇 |
1992年 | 6篇 |
1991年 | 6篇 |
1990年 | 10篇 |
1989年 | 14篇 |
1988年 | 14篇 |
1987年 | 13篇 |
1986年 | 1篇 |
1985年 | 7篇 |
1984年 | 1篇 |
1983年 | 5篇 |
1982年 | 7篇 |
1981年 | 2篇 |
1980年 | 4篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1976年 | 5篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1968年 | 2篇 |
1918年 | 2篇 |
排序方式: 共有404条查询结果,搜索用时 0 毫秒
81.
Severe outcomes of allogeneic and autologous blood donation: frequency and characterization 总被引:8,自引:0,他引:8
BACKGROUND: There are few published data on severe outcomes of the donation of blood for allogeneic or autologous use. It would be helpful if blood collectors could better characterize and/or predict the likelihood of significant complications of blood donation. STUDY DESIGN AND METHODS: Very severe outcome (VSO) was defined as an event requiring hospitalization. Approximately 4.1 million American Red Cross whole-blood donation records (July 1993-March 1994) were reviewed for the incidence and type of VSO. RESULTS: A total of 33 VSOs occurred for all donations. The incidence of VSOs for allogeneic donation was 1 (0.0005%) in 198,119 and that for autologous donation was 1 (0.006%) in 16,783 (p < 0.001). First-time donors were three times as likely to have a VSO. Donors > 40 years old had 87.9 percent of the VSOs, and donors > 60 years old had 48.5 percent. Vasovagal (66.7%) and anginal (12.1%) episodes were the most frequent complications, and 66.7 percent of reactions occurred at the blood collection site. The mean hospital stay was 1.9 days. CONCLUSION: VSO is an infrequent complication of all types of blood donation, but its occurrence may be associated with significant morbidity and cost. VSO is nearly 12 times as likely in autologous blood donors. 相似文献
82.
83.
84.
85.
J. Prendiville D. Crowther N. Thatcher P. J. Woll B. W. Fox A. McGown N. Testa P. Stern R. McDermott M. Potter et al. 《British journal of cancer》1993,68(2):418-424
Bryostatin 1 is a novel antitumour agent derived from Bugula neritina of the marine phylum Ectoprocta. Nineteen patients with advanced solid tumours were entered into a phase I study to evaluate the toxicity and biological effects of bryostatin 1. Bryostatin 1 was given as a one hour intravenous infusion at the beginning of each 2 week treatment cycle. A maximum of three treatment cycles were given. Doses were escalated in steps from 5 to 65 micrograms m-2 in successive patient groups. The maximum tolerated dose was 50 micrograms m-2. Myalgia was the dose limiting toxicity and was of WHO grade 3 in all three patients treated at 65 micrograms m-2. Flu-like symptoms were common but were of maximum WHO grade 2. Hypotension, of maximum WHO grade 1, occurred in six patients treated at doses up to and including 20 micrograms m-2 and may not have been attributable to treatment with bryostatin 1. Cellulitis and thrombophlebitis occurred at the bryostatin 1 infusion site of patients treated at all dose levels up to 50 micrograms m-2, attributable to the 60% ethanol diluent in the bryostatin 1 infusion. Subsequent patients treated at 50 and 65 micrograms m-2 received treatment with an intravenous normal saline flush and they did not develop these complications. Significant decreases of the platelet count and total leucocyte, neutrophil and lymphocyte counts were seen in the first 24 h after treatment at the dose of 65 micrograms m-2. Immediate decreases in haemoglobin of up to 1.9g dl-1 were also noted in patients treated with 65 micrograms m-2, in the absence of clinical evidence of bleeding or haemodynamic compromise. No effect was observed on the incidence of haemopoietic progenitor cells in the marrow. Some patients'' neutrophils demonstrated enhanced superoxide radical formation in response to in vitro stimulation with opsonised zymosan (a bacterial polysaccharide) but in the absence of this additional stimulus, no bryostatin 1 effect was observed. Lymphocyte natural killing activity was decreased 2 h after treatment with bryostatin 1, but the effect was not consistently seen 24 h or 7 days later. With the dose schedule examined no antitumour effects were observed. We recommend that bryostatin 1 is used at a dose of 35 to 50 micrograms m-2 two weekly in phase II studies in patients with malignancies including lymphoma, leukaemia, melanoma or hypernephroma, for which pre-clinical investigations suggest antitumour activity. 相似文献
86.
NL Hoenderdos NAM Rosema DE Slot MF Timmerman U van der Velden GA van der Weijden 《International journal of dental hygiene》2009,7(4):294-298
Abstract: Aim: To evaluate the inhibition of plaque growth by an experimental mouthrinse (BioXyl®) based on hydrogen peroxide/glycerol. Design: It was a double‐blind, randomized study involving 40 volunteers in good general health. At the start of the trial, all participants received a dental prophylaxis to remove all plaque deposits. During the next 3 days subjects refrained from any mechanical oral hygiene procedure, except for the allocated mouthrinse being either the hydrogen peroxide (H2O2; 0.013% H2O2/0.004% glycerol) or the placebo without H2O2. At the third day of appointment, plaque levels were assessed at six sites per tooth. Results: The test group had a mean overall plaque score of 2.66 and the placebo group of 2.70. The difference in plaque scores between the two groups was not statistically significant. Conclusions: The results of this pilot study showed that there was no statistically significant difference between the H2O2/glycerol group and the placebo group with respect to plaque inhibition within this study design. 相似文献
87.
We studied cytotoxic activity of acute myelogenous leukemia (AML) sera for AML blasts before and after immunoadsorption with Staphylococcus aureus, Cowan I (SAC), which contains protein A. We found in vitro that incubation with treated AML sera reduced viability to 42.7% of control (p less than 0.01) for autologous and 21.0% of control (p less than 0.01) for allogeneic blasts. Normal peripheral blood cells were not killed by treated AML sera. Wood 46 strain of Staphylococcus aureus, which does not contain protein A, did not significantly reduce AML blast viability (94.8%, p greater than 0.4), while Sepharose-bound protein A reduced viability to 63.8% (p less than 0.01). Cytotoxicity does not appear to be complement-mediated, byt cytotoxic activity is trypsin-sensitive and is contained in the immunoglobulin fraction. This model for study of the tumoricidal action of protein A adsorption should be useful for predicting utility of plasma adsorption as a therapeutic adjunct in the future. 相似文献
88.
89.
AK Hiett ; KA Britton ; NL Hague ; HL Brown ; FB Stehman ; HE Broxmeyer 《Transfusion》1995,35(7):587-591
BACKGROUND: Cord blood has been used for transplantation. The purpose of this study was to compare numbers of hematopoietic progenitors in cord blood collected from neonatal infants who are small for their gestational age and those who are normal. STUDY DESIGN AND METHODS: Sixteen pregnant women diagnosed with intrauterine growth restriction were prospectively identified. Cord blood was collected at delivery. Fourteen cord blood samples were obtained from gestational age-matched, appropriately grown newborns. In vitro assays for hematopoietic progenitors were performed and results of the two compared. Comparisons were also made with numbers of hematopoietic progenitor cells previously found by this laboratory in samples collected with the possibility of use for transplantation. RESULTS: Gestational age, the women's pregnancy and delivery histories, maternal risk factors for intrauterine growth restriction, maternal age, delivery method, umbilical cord blood gases, and 5-minute Apgar scores were similar in the two groups. Newborns who were small for their gestational age had significantly lower birth weights and longer stays in the neonatal intensive care unit with no evidence for viral infections in the immediate neonatal period. The mean number of progenitors per collection of cord blood in the small newborns was about half that per collection from appropriately grown newborns, but in most cases, these differences were not significant in the two groups, and many numbers in the small newborns fell within the range associated with successfully engrafting cord blood collections. CONCLUSION: Hematopoietic progenitor cells in the small newborns may be adequate for transplantation purposes in many cases. Their possible use in this context should, however, involve careful consideration of the numbers of progenitors collected as well as of possible viral or other contamination. 相似文献
90.
Michelle N. Rheault Lei Zhang David T. Selewski Mahmoud Kallash Cheryl L. Tran Meredith Seamon Chryso Katsoufis Isa Ashoor Joel Hernandez Katarina Supe-Markovina Cynthia D'Alessandri-Silva Nilka DeJesus-Gonzalez Tetyana L. Vasylyeva Cassandra Formeck Christopher Woll Rasheed Gbadegesin Pavel Geier Prasad Devarajan Shannon L. Carpenter Bryce A. Kerlin William E. Smoyer 《Clinical journal of the American Society of Nephrology》2015,10(12):2110-2118