Measurement of renin in segmental renal veins of hypertensives

In 27 of 270 patients studies for possible renovascular hypertension, a lesion affecting a segmental renal artery was seen on angiography. In 22 patients who had sufficient data, the significance of measuring segmental-renal-vein renin in the diagnosis and treatment of segmental disease was evaluated. In 11 (50%), the renin values of segmental vessels supported the clinical diagnosis. In four (36%) of these 11, a high-renin-release area would not have been identified without the stress of upright posture. Successful treatment of hypertension was achieved in six of nine patients who had a revascularization procedure or resection of the segmental vessels. Samples from involved and uninvolved segments of the kidney as well as from the contralateral renal vein and inferior vena cava, together with the stimuli of sodium and volume depletion augmented by upright posture, enabled confirmation of the angiographic diagnosis of segmental-renovascular hypertension.     

Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum

Chronic helminth infections induce T‐cell hyporesponsiveness, which may affect immune responses to other pathogens or to vaccines. This study investigates the influence of Treg activity on proliferation and cytokine responses to BCG and Plasmodium falciparum‐parasitized RBC in Indonesian schoolchildren. Geohelminth‐infected children's in vitro T‐cell proliferation to either BCG or pRBC was reduced compared to that of uninfected children. Although the frequency of CD4⁺CD25^hiFOXP3⁺ T cells was similar regardless of infection status, the suppressive activity differed between geohelminth‐infected and geohelminth‐uninfected groups: Ag‐specific proliferative responses increased upon CD4⁺CD25^hi T‐cell depletion in geohelminth‐infected subjects only. In addition, IFN‐γ production in response to both BCG and parasitized RBC was increased after removal of CD4⁺CD25^hi T cells. These data demonstrate that geohelminth‐associated Treg influence immune responses to bystander Ag of mycobacteria and plasmodia. Geohelminth‐induced immune modulation may have important consequences for co‐endemic infections and vaccine trials.     

MBTI人格类型量表的效度分析

0引言MBTI（Myers－BrlggstypeIndicator）是目前国际流行的著名量表之一,在职业指导、管理者评估中占居独特地位,全世界每年有170万人接受MBTI的测试．自1994年,我们与美国东卡罗莱纳大学合作,翻译MBTI量表,先后取样3000多名被试作修订工作．本文是第三次修订结果,以探讨中文版MBTI人格测验的内容效度、效标关联效度和结构效度．巨研究方法1．T被试对象西安市大学本科生和专科生1745名．平均20．5岁,男1368名,女377名．l．2MBTI量表对美国1987年版MBTI－G量表进行翻译和修订．修订原则为,题目应符合中国的文化背景和…     

蛇床子素对豚鼠离体回肠和结肠带的作用

以豚鼠离体回肠和结肠带为标本,观察蛇床子素(Ost)的作用与Ca²⁺)的关系。结果表明:Ost和钙拮抗剂Ver产生剂量依赖性抑制乙酰胆碱(ACh)、组胺及KCl所致回肠条或结肠带的收缩;非竞争性拮抗CaCl₂累积量—效曲线,pD₂分别为4.41±0.15,7.0±0.2。Ost 100μmol/L和Ver 1μmol/L均能对抗小剂量Ca²⁺所致结肠带收缩,但被加入较大量Ca²⁺所取消。Ost和Ver均能抑制ACh诱导的依内钙性收缩,不影响依外钙性收缩。结果提示Ost具有钙拮抗作用,其作用方式与Ver类似。     

岩筋菜中三萜的研究

从岩筋菜(Bemevxia thibetica Decne)地上部分的乙醇提取物中分得四个三萜,经光谱解析鉴定了一个新化合物,16α,21β,22α,28-四羟基齐墩果-12-烯-3-酮,命名为岩筋菜素(bemeuxin,Ⅰ)。其余三个是已知物,即21-惕各酰基玉蕊皂甙元C(Ⅱ),2α,3α-二羟基乌苏酸(Ⅲ)和2α,3β-二羟基乌苏酸(Ⅳ)。     

Educating teachers of nursing: the attitudes of students

One hundred and twenty-four experienced registered nurses representing four status categories (nurse managers, full-time student teachers of nursing, first year part-time student teachers of nursing, and second year part-time teachers of nursing) participated in a study to investigate the nature of their social attitudes.
Oliver's Survey of Opinions about Education was used as a measure of social attitudes.
The overall conclusion was that the social attitudes of the subjects in the study were more similar than dissimilar. Significant differences were found between the managers and the full time teachers (t =−2.03, P < 0.05) on radicalism. The teachers were found to be more radical. Significant differences were found between the managers and the first year part-time teachers (t =−2.55, P < 0.05) on tender-mindedness. The teachers were found to be more tender-minded. Significant differences were also found on tender-mindedness between the managers and the second year part-time teachers (t =−2.37, P < 0.05). Again, the teachers were found to be more tender-minded than the managers. Apart from these differences, the social attitudes of the subjects were found to be well balanced.
When the findings of the present study are compared with other studies relating to the social attitudes of nurses, the pattern which emerges is a more balanced one. However, previous studies mainly used subjects in the l8–21-year age group. The difference in the ages of the subjects is likely to be an important factor on their social attitudes, but further research would be required to determine whether factors other than a difference in ages play a part.