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BACKGROUND: Male sexual jealousy provoked by threatened exclusive access to a female mate is a frequently reported motive in cases involving spousal abuse. Dominant male rhesus macaques also respond aggressively to threats to mating exclusivity. METHODS: Nine dominant male monkeys were injected with [(18)F]-fluorodeoxyglucose ([(18)F]-FDG) and then exposed to one of two conditions: a "challenge" condition in which they witnessed a potential sexual interaction between their female consort and a rival male, and a control condition in which the consort was present without the rival male. After the brain uptake period for [(18)F]-FDG, dominant males were sedated, blood samples were drawn, and regional cerebral glucose metabolism was measured with positron emission tomographic imaging. RESULTS: Males that showed larger increases in plasma testosterone in the challenge condition showed more aggression and greater activation in the central gray matter of the midbrain, a brain area rich in androgen receptors. The challenge condition was associated with activation in both right superior temporal sulcus and right amygdala, which might relate to increased social vigilance and anxiety, respectively. CONCLUSIONS: Sexual jealousy in male humans is also often accompanied by vigilance behavior and anxiety and might recruit a similar neural network to that described here. 相似文献
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The purpose of this study was objective documentation of clinical benefits of bilevel positive airway pressure in pediatric patients with obstructive sleep apnea. We performed a retrospective chart review and data collection/analysis in a suburban tertiary care children's hospital. The study consisted of 10 pediatric patients (age range: 3 to 18 years); 3 patients had craniofacial abnormalities, 1 patient had neuromuscular disease, and 6 patients were obese. Eleven-channel polysomnography and support with bilevel positive airway pressure were used. We measured obstructive sleep apnea indices, lowest oxygen saturation rate, and average breath lengths before and after bilevel positive airway pressure use. We found that the apnea index decreased from 19.7 +/- 26.46 to 0.82 +/- 1.01, the lowest oxygen saturation increased from 75.60% +/- 14.93% to 89.50% +/- 5.50%, and breath length increased from 3.22 +/- 0.95 to 3.68 +/- 0.82. Bilevel positive airway pressure may be considered as a treatment modality for pediatric patients with obstructive sleep apnea. 相似文献
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OBJECTIVE: The radial forearm free flap has become the method of choice for reconstruction of head and neck defects following oncologic ablation. Harvesting of a radial forearm free flap leaves a donor site defect. This is most commonly closed with a split-thickness skin graft. Morbidity, most commonly owing to a lack of graft take over the tendons, can be quite high. Recently, an acellular matrix (Alloderm) has been advocated to decrease complications at the radial forearm donor site, as well as obviate taking a split-thickness skin graft from the thigh. MATERIAL AND METHODS: Tertiary referral academic centre. Retrospective chart review of 15 patients. Five patients received allogenic dermis, 10 patients received split-thickness skin grafting to the radial forearm donor site. RESULTS: Patients with allogenic dermis took between 12 and 16 weeks to heal completely. Patients undergoing split-thickness skin graft were completely healed within 4 to 6 weeks. Cosmesis was judged to be marginally better in the allogenic dermis group. Allogenic dermis placement had a greater impact on hand function owing to prolonged healing, whereas patients with split-thickness skin graft required wound care at the thigh for a 2- to 3-week period owing to the harvesting of the skin graft. CONCLUSIONS: Allogenic dermis may be a viable alternative to split-thickness skin grafting and radial forearm free flap donor sites. Prolonged healing with subsequent increased health care services use needs to be addressed. 相似文献
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Preoperative fasting: old habits die hard 总被引:19,自引:0,他引:19
OVERVIEW: Prolonged preoperative fasting is a time-honored tradition. The typical order of "npo after midnight" (or no liquid or food after 12 am on the day of surgery) has been challenged in recent years-so much so that in 1999 the American Society of Anesthesiology (ASA) revised its practice guidelines for preoperative fasting in healthy patients undergoing elective procedures. The newer, more liberal recommendations, based on studies showing that pulmonary aspiration occurs only rarely as a complication of modern anesthesia, allow the consumption of clear liquids up to two hours before elective surgery, a light breakfast (tea and toast, for example) six hours before the procedure, and a heavier meal eight hours beforehand.There is a well-known lag between the dissemination and implementation of practice guidelines, so the authors sought to determine whether the publication of the revised ASA recommendations had changed preoperative fasting practices. They interviewed 155 patients in one hospital about their preoperative fasting, comparing instructed, actual, and ASA-recommended fasting durations for liquids and solids. Their findings demonstrate that the majority of patients continued to receive instructions of npo after midnight for both liquids and solids, whether they were scheduled for early or late surgery. On average, the patients fasted from liquids and solids for 12 and 14 hours, respectively, with some patients fasting as long as 20 hours from liquids and 37 hours from solids. These fasts were significantly longer than those recommended by the ASA, indicating that inappropriate preoperative fasting is an issue that demands attention.The authors conclude that more collaboration between nurses and physicians is needed to assure that fasting instructions are consistent with the ASA guidelines and that patients understand these directives. 相似文献
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Research shows that there is a direct correlation between the quality of nurses' work environments and the quality of client care. RNABC's newest policy statement, Nursing Practice Environments for Safe and Appropriate Care, identifies the key elements in an organization that are associated with improved client outcomes through attraction and retention of nurses. 相似文献