全文获取类型
收费全文 | 5291篇 |
免费 | 424篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 85篇 |
儿科学 | 141篇 |
妇产科学 | 112篇 |
基础医学 | 587篇 |
口腔科学 | 246篇 |
临床医学 | 586篇 |
内科学 | 1100篇 |
皮肤病学 | 132篇 |
神经病学 | 344篇 |
特种医学 | 349篇 |
外国民族医学 | 1篇 |
外科学 | 753篇 |
综合类 | 105篇 |
一般理论 | 4篇 |
预防医学 | 361篇 |
眼科学 | 106篇 |
药学 | 236篇 |
1篇 | |
中国医学 | 5篇 |
肿瘤学 | 471篇 |
出版年
2018年 | 58篇 |
2016年 | 55篇 |
2015年 | 55篇 |
2014年 | 77篇 |
2013年 | 119篇 |
2012年 | 152篇 |
2011年 | 177篇 |
2010年 | 131篇 |
2009年 | 113篇 |
2008年 | 178篇 |
2007年 | 223篇 |
2006年 | 218篇 |
2005年 | 186篇 |
2004年 | 177篇 |
2003年 | 185篇 |
2002年 | 187篇 |
2001年 | 174篇 |
2000年 | 186篇 |
1999年 | 149篇 |
1998年 | 88篇 |
1997年 | 88篇 |
1996年 | 78篇 |
1995年 | 69篇 |
1994年 | 69篇 |
1993年 | 54篇 |
1992年 | 134篇 |
1991年 | 148篇 |
1990年 | 123篇 |
1989年 | 133篇 |
1988年 | 150篇 |
1987年 | 133篇 |
1986年 | 126篇 |
1985年 | 140篇 |
1984年 | 101篇 |
1983年 | 107篇 |
1982年 | 75篇 |
1981年 | 60篇 |
1980年 | 48篇 |
1979年 | 82篇 |
1978年 | 73篇 |
1977年 | 57篇 |
1976年 | 73篇 |
1975年 | 46篇 |
1974年 | 55篇 |
1973年 | 58篇 |
1972年 | 52篇 |
1971年 | 52篇 |
1970年 | 50篇 |
1969年 | 46篇 |
1968年 | 41篇 |
排序方式: 共有5725条查询结果,搜索用时 0 毫秒
101.
102.
103.
104.
B G Melamed D Weinstein M Katin-Borland R Hawes 《Journal of the American Dental Association (1939)》1975,90(4):822-826
In this study of the modification of anxiety-related disruptive behavior in dental treatment, matched groups of inner-city children attending a pedodontic clinic were shown a videotaped demonstration of a 4-year-old black child undergoing a dental restorative procedure or were given an unrelated drawing task before dental treatment. Children who viewed the videotape demonstration of a peer model coping with dental procedures showed significantly fewer fear-related disruptive behaviors during restoration of lesions. Observations of children's anxiety levels made by dentists and independent observers validated the effectiveness of viewing the videotaped demonstration. No significant correlation was found between the children's reports of their anxiety and their behavior during dental treatment. 相似文献
105.
Subareolar and peritumoral injection identify similar sentinel nodes for breast cancer 总被引:9,自引:0,他引:9
Bauer TW Spitz FR Callans LS Alavi A Mick R Weinstein SP Bedrosian I Fraker DL Bauer TL Czerniecki BJ 《Annals of surgical oncology》2002,9(2):169-176
Background Sentinel lymph node (SLN) mapping with radioisotope and blue dye is rapidly becoming the standard of care for breast cancer.
The optimal location for injection of radioisotope and blue dye is still being investigated. The goal of this study was to
determine whether blue dye injection into the subareolar (SA) location localized the same sentinel nodes as the peritumoral
(PT) location for patients with breast cancer.
Methods Three hundred thirty-two patients with biopsy-proven operable breast cancer or ductal carcinoma in situ at two institutions
underwent SLN mapping. Eighty-three patients had PT injection of blue dye (group 1), and 249 patients had SA injection of
blue dye (group 2). All patients underwent PT injection of99mTc-labeled sulfur colloid.
Results The two groups were similar in age, previous biopsy type, and tumor size, location, and histology. The mean number of SLNs
identified was 2.4 (range, 0–9) in group 1 and 2.5 (range, 0–11) in group 2. The SLN identification rate was 95% for group
1 and 97% for group 2. The isotope success rate was 94% for both groups. The blue dye success rate was 84% for group 1 and
90% for group 2. The isotope/blue dye concordance rate was 87% for group 1 and 90% for group 2. At a median follow-up of 28
months (range, 14 to 40), there were no axillary recurrences in any of the 332 patients.
Conclusions These data suggest that delivery of mapping reagents in the SA and PT locations identifies similar lymph nodes. Because of
simplicity and the similarity in node identification between SA and PT injection, further investigation of the SA site for
delivery of SLN mapping reagents for breast cancer is warranted.
Presented at the 54th Annual Cancer Symposium, Society of Surgical Oncology. Washington, DC, March 15–18, 2001. 相似文献
106.
Haskell J. Weinstein MD 《Archives of environmental & occupational health》2013,68(6):779-783
The acceleration of tumor production in mice by repeated application of polycyclic aromatic hydrocarbon carcinogens of high and low potency in the presence of cocarcinogenic compounds is described. Experiments exploring the concentration levels of carcinogen and cocarcinogen necessary to produce tumors demonstrate that there is a 1,000-fold increase in the enhancement of potency of low concentrations of benzo[a]pyrene and benz[a]anthracene when n-dodecane is the diluent. The effect of cocarcinogens is most obvious during exposure to low concentrations of carcinogen. The implications of this observation in the environment is discussed. 相似文献
107.
Anthony J. Bonito Costica Aloman M. Isabel Fiel Nichole M. Danzl Sungwon Cha Erica G. Weinstein Seihwan Jeong Yongwon Choi Matthew C. Walsh Konstantina Alexandropoulos 《The Journal of clinical investigation》2013,123(8):3510-3524
TRAF6, an E3 ubiquitin protein ligase, plays a critical role in T cell tolerance by regulating medullary thymic epithelial cell (mTEC) development. mTECs regulate T cell tolerance by ectopically expressing self-antigens and eliminating autoreactive T cells in the thymus. Here we show that mice with mTEC depletion due to conditional deletion of Traf6 expression in murine thymic epithelial cells (Traf6ΔTEC mice) showed a surprisingly narrow spectrum of autoimmunity affecting the liver. The liver inflammation in Traf6ΔTEC mice exhibited all the histological and immunological characteristics of human autoimmune hepatitis (AIH). The role of T cells in AIH establishment was supported by intrahepatic T cell population changes and AIH development after transfer of liver T cells into immunodeficient mice. Despite a 50% reduction in natural Treg thymic output, peripheral tolerance in Traf6ΔTEC mice was normal, whereas compensatory T regulatory mechanisms were evident in the liver of these animals. These data indicate that mTECs exert a cell-autonomous role in central T cell tolerance and organ-specific autoimmunity, but play a redundant role in peripheral tolerance. These findings also demonstrate that Traf6ΔTEC mice are a relevant model with which to study the pathophysiology of AIH, as well as autoantigen-specific T cell responses and regulatory mechanisms underlying this disease. 相似文献
108.
Da H. Le David B. Reed Gail Weinstein Matthew Gregory Lawrence H. Brown 《Prehospital emergency care》2013,17(2):155-158
Objective. To evaluate the ability of paramedics to learn and apply the skill of introducer-aided oral intubation in the setting of the simulated “difficult airway.” The authors hypothesized that, following a brief introduction to the device, intubation success rates would not differ for traditional and introducer-aided intubations of an immobilized airway mannequin. Methods. During a paramedic recertification class, experienced paramedics were given a brief didactic introduction to the “bougie-like” Flex Guide endotracheal tube introducer (ETTI). The participants were then asked to intubate adult mannequins immobilized in the head-neutral position, with and without the ETTI. “Successful placement” was defined as completion of the procedure within 30 seconds and endotracheal tube position confirmed by the investigator with direct visualization. Results. For both traditional and ETTI intubations, 34 (97%) of the 35 paramedics successfully intubated within 30 seconds. The two unsuccessful intubation attempts were recognized by the paramedic as esophageal intubations, and correct tube placement was obtained within an additional 30 seconds. Conclusion. In this study, use of the ETTI was mastered by the participants after only a brief didactic introduction to the device, with their ability to intubate an immobilized mannequin using the ETTI being equal to their ability to perform traditional intubation. These results suggest that use of the ETTI is easily learned, and may support the device's role in the prehospital management of the difficult airway. 相似文献
109.
Jenny Weinstein Principal Lecturer 《Journal of interprofessional care》2013,27(3):325-326
There exist numerous difficulties in the recruitment of patients to drug trials for Alzheimer's disease. This article describes a successful community-based case-finding strategy. The success is largely attributed to effective liaison between the co-ordinating psychiatrist, GPs, community psychiatric nurses and practice nurses. 相似文献
110.
Randomized use of cyclosporin A (CsA) to modulate P-glycoprotein in children with AML in remission: Pediatric Oncology Group Study 9421 下载免费PDF全文
Becton D Dahl GV Ravindranath Y Chang MN Behm FG Raimondi SC Head DR Stine KC Lacayo NJ Sikic BI Arceci RJ Weinstein H;Pediatric Oncology Group 《Blood》2006,107(4):1315-1324
Relapse is a major obstacle in the cure of acute myeloid leukemia (AML). The Pediatric Oncology Group AML Study 9421 tested 2 different strategies to improve event-free survival (EFS) and overall survival (OS). Patients were randomized to receive standard-dose DAT (daunorubicin, cytarabine, and thioguanine) or high-dose DAT during induction. To interfere with P-glycoprotein (P-gp)-dependent drug efflux, the second randomization tested the benefit of cyclosporine (CsA) added to consolidation chemotherapy. Of the 282 children randomly assigned to receive standard DAT induction, 248 (87.9%) achieved remission compared to 253 (91%) of the 278 receiving high-dose DAT (P = ns). Children with HLA-identical sibling donors who achieved a complete remission received an allogeneic bone marrow transplant as consolidation. For the 83 patients receiving a matched related donor bone marrow transplantation (BMT), the 3-year disease-free survival (DFS) is 67%. Of the 418 children who achieved remission and went on to consolidation with and without CsA, the DFS was 40.6% and 33.9%, respectively (P = .24). Overexpression of P-gp was infrequent (14%) in this pediatric population. In this study, intensifying induction with high-dose DAT and the addition of CsA to consolidation chemotherapy did not prolong the durations of remission or improve overall survival for children with AML. 相似文献