情绪突然应激引致心脏顿抑的神经内分泌特征

情绪应激能触发可逆性左心室功能不良，但机制未明。作者评估突然情绪应激后左心室功能不良19例，均经血管影像和系列超声心动图检查，5例作心肌心内膜活检，对13例与7例KillipⅢ级的心肌梗死病人的血浆儿茶酚胺水平作比较。病人中位年龄63岁。妇女占95％。临床症状有胸痛、肺水肿、心源性休克，多数有散在性T波倒置和QT间期延长。     

Nasopharyngeal carcinoma: clinical and radiographic findings in children

Nasopharyngeal carcinoma (NPC) in childhood occurs so infrequently that it is not suspected in affected children until the disease has been present for a long time and local spreading has occurred. The survival rates are therefore quite poor. Six children with NPC are described. A massive local lymph node spread simulating lymphoma was present in half of the patients; in the other half the disease was more subtle, presenting with epistaxis and CNS involvement. If an evaluation of the nasopharynx were part of the initial physical examination in children, the diagnosis of NPC would be made earlier and survival rates would improve.     

Low prevalence of <Emphasis Type=Italic>H. pylori</Emphasis> Infection in HIV-Positive Patients in the Northeast of Brazil

Background  

This study conducted in Northeastern Brazil, evaluated the prevalence of H. pylori infection and the presence of gastritis in HIV-infected patients.     

Multi-modal quantitative MRI investigation of brain tissue neurodegeneration in multiple sclerosis

Purpose:

To investigate the utility of multimodal quantitative MRI (qMRI) and atlas‐based methods to identify characteristics of lesion‐driven injury and neurodegeneration in relapsing remitting multiple sclerosis (RRMS).

Materials and Methods:

This work is health insurance portability and accountability act compliant. High resolution T1‐weighted, dual echo, and fluid‐attenuated inversion recovery and diffusion tensor MRI images were prospectively acquired on 68 RRMS patients (range, 25–58 years) and 68 age‐matched controls. The data were analyzed using standardized human brain atlas‐based tissue segmentation procedures to obtain regional volumes and their corresponding T2 relaxation times and DTI maps.

Results:

Group‐averaged brain atlas‐based qMRI maps of T2, fractional anisotropy and diffusivities are visually presented and compared between controls and RRMS. The analysis shows a widespread injury in RRMS. Atrophy of the corpus callosum (CC) was substantial in RRMS. The qMRI attributes of the neocortex in combination with the CC such as T2 and diffusivities were elevated and correlated with disability.

Conclusion:

Using a standardized multimodal qMRI acquisition and analyses that accounted for lesion distribution we demonstrate that cerebral pathology is widespread in RRMS. Our analysis of CC and neocortex qMRI metrics in relation to disability points to a neurodegenerative injury component that is independent from lesions. J. Magn. Reson. Imaging 2012;35:1300–1311. © 2012 Wiley Periodicals, Inc.