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排序方式: 共有777条查询结果,搜索用时 15 毫秒
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Matteo Airaldi MD Alessandro Invernizzi MD Vuong Nguyen PhD Stela Vujosevic MD PhD Federico Ricci MD Pietro Monaco MD Marco Nassisi MD Daniel Barthelmes MD PhD Mark Gillies MD PhD Francesco Viola MD 《Clinical & experimental ophthalmology》2023,51(8):799-807
Background
To compare 24-month real-world outcomes of Vascular Endothelial Growth Factor (VEGF) inhibitors for Polypoidal Choroidal Vasculopathy (PCV) and type 1 Macular Neovascularization (MNV) in a Caucasian population.Methods
Retrospective analysis from a prospectively designed observational database. Data from Italian centres participating in the Fight Retinal Blindness! (FRB!) project were collected. Treatment-naïve PCV or type 1 MNV commencing treatment after January 2009 were included. The primary outcome was 24-month visual acuity (VA) change; other outcomes included baseline characteristics, number of anti-VEGF injections, time to lesion inactivation and proportion of active visits.Results
A total of 322 eyes (114 PCVs) from 291 patients were included. Median [Q1, Q3] VA at baseline was comparable (70 [55, 75.8] vs. 70 [58.8, 75] letters, p = 0.95). Adjusted VA change at 2 years was higher in PCV (mean [95% CI], +1.2 [−1.6, 4.1] vs. −3.6 [−6, −1.2] letters, p = 0.005). PCV received fewer anti-VEGF injections over the first 24 months of treatment than type 1 MNV (median [Q1, Q3], 8 [5, 10] vs. 9 [7, 12.2] injections, p = 0.001), inactivated earlier (median [Q1, Q3], 235 [184, 308] vs. 252 [169, 343] days, p = 0.04) and was less frequently graded ‘active’ (62% vs. 68% of visits, p = 0.001).Conclusions
PCV had slightly better VA outcomes over 24 months of treatment than type 1 MNV after receiving less anti-VEGF injections. These results suggest a possible overlap of the two clinical entities with similar visual prognosis in Caucasians. 相似文献773.
Caroline Vuong Ibtissame Moussa Maud M. van Muilekom Harriët Heijboer Eva Rettenbacher Lotte Haverman Jos Twisk Karin Fijnvandraat Corien L. Eckhardt 《Pediatric blood & cancer》2023,70(12):e30691
Background
Sickle cell disease (SCD) is characterized by vaso-occlusive crises (VOCs) that impair the health-related quality of life (HRQoL). The aim of this study is to evaluate the impact of hospitalization for VOCs on HRQoL in children with SCD over time.Methods
In this longitudinal cohort study, children aged 8–18 years diagnosed with SCD at the Amsterdam UMC were included between 2012 and 2021. HRQoL was annually measured as part of standard care using the Pediatric Quality of Life Inventory. The impact of hospitalization for VOC on HRQoL was evaluated using linear mixed models 3, 6, 9, and 12 months after hospitalization. The effect of frequency of hospitalization for VOC on HRQoL was evaluated over the last 12 months.Results
In total, 94 children with SCD were included with a median age of 11.8 years (interquartile range [IQR]: 9–14). Thirty-seven patients (39%) had been hospitalized for a VOC. Hospitalization for VOC led to a decrease of 3.2–4.8 points in total HRQoL compared to patients without hospitalization, most pronounced 3 months after hospitalization. Recurrent admission for VOC in the last 12 months was associated with a decrease of 2.3 points in total HRQoL (p = .04). The most affected subscale was physical functioning.Conclusion
The adverse effects of hospitalization for VOC in children with SCD persist up to 12 months after hospitalization. After hospitalization for VOC, extra attention and support for its negative impact on HRQoL are recommended. This study also underlines the importance of systematically measuring HRQoL, allowing clinicians to intervene accordingly. 相似文献774.
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Phillip C. Nguyen Vuong Nguyen Kylie Baldwin Yamuna Kankanige Piers Blombery Neil Came David A. Westerman 《British journal of haematology》2023,202(4):760-770
Undetectable measurable residual disease (MRD) is associated with favourable clinical outcomes in chronic lymphocytic leukaemia (CLL). While assessment is commonly performed using multiparameter flow cytometry (MFC), this approach is associated with limitations including user bias and expertise that may not be widely available. Implementation of unsupervised clustering algorithms in the laboratory can address these limitations and have not been previously reported in a systematic quantitative manner. We developed a computational pipeline to assess CLL MRD using FlowSOM. In the training step, a self-organising map was generated with nodes representing the full breadth of normal immature and mature B cells along with disease immunophenotypes. This map was used to detect MRD in multiple validation cohorts containing a total of 456 samples. This included an evaluation of atypical CLL cases and samples collected from two different laboratories. Computational MRD showed high correlation with expert analysis (Pearson's r > 0.99 for typical CLL). Binary classification of typical CLL samples as either MRD positive or negative demonstrated high concordance (>98%). Interestingly, computational MRD detected disease in a small number of atypical CLL cases in which MRD was not detected by expert analysis. These results demonstrate the feasibility and value of automated MFC analysis in a diagnostic laboratory. 相似文献
777.
Luca Campedel Eva Compérat Géraldine Cancel-Tassin Justine Varinot Christian Pfister Clara Delcourt Françoise Gobet Mathieu Roumiguié Pierre-Marie Patard Gwendoline Daniel Pierre Bigot Julie Carrouget Caroline Eymerit Stéphane Larré Priscilla Léon Anne Durlach Alain Ruffion Emilien Seizilles de Mazancourt Myriam Decaussin-Petrucci Thomas Bessède Cédric Lebacle Sophie Ferlicot Grégoire Robert Nam-Son Vuong Magali Philip Sébastien Crouzet Xavier Matillon Florence Mège-Lechevallier Hervé Lang Pascal Mouracade Véronique Lindner Paul Gougis Olivier Cussenot Morgan Rouprêt Thomas Seisen 《BJU international》2023,132(5):581-590