全文获取类型
收费全文 | 1288篇 |
免费 | 115篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 100篇 |
妇产科学 | 34篇 |
基础医学 | 160篇 |
口腔科学 | 38篇 |
临床医学 | 186篇 |
内科学 | 287篇 |
皮肤病学 | 29篇 |
神经病学 | 57篇 |
特种医学 | 170篇 |
外科学 | 89篇 |
综合类 | 26篇 |
预防医学 | 77篇 |
眼科学 | 12篇 |
药学 | 89篇 |
1篇 | |
中国医学 | 9篇 |
肿瘤学 | 80篇 |
出版年
2022年 | 3篇 |
2021年 | 12篇 |
2020年 | 14篇 |
2019年 | 10篇 |
2018年 | 29篇 |
2017年 | 25篇 |
2016年 | 33篇 |
2015年 | 34篇 |
2014年 | 42篇 |
2013年 | 54篇 |
2012年 | 27篇 |
2011年 | 43篇 |
2010年 | 47篇 |
2009年 | 81篇 |
2008年 | 43篇 |
2007年 | 60篇 |
2006年 | 28篇 |
2005年 | 37篇 |
2004年 | 25篇 |
2003年 | 26篇 |
2002年 | 18篇 |
2001年 | 33篇 |
2000年 | 27篇 |
1999年 | 29篇 |
1998年 | 77篇 |
1997年 | 85篇 |
1996年 | 59篇 |
1995年 | 51篇 |
1994年 | 43篇 |
1993年 | 45篇 |
1992年 | 27篇 |
1991年 | 18篇 |
1990年 | 16篇 |
1989年 | 34篇 |
1988年 | 26篇 |
1987年 | 32篇 |
1986年 | 17篇 |
1985年 | 24篇 |
1984年 | 18篇 |
1983年 | 14篇 |
1982年 | 12篇 |
1981年 | 10篇 |
1980年 | 11篇 |
1978年 | 6篇 |
1977年 | 12篇 |
1976年 | 5篇 |
1975年 | 3篇 |
1967年 | 2篇 |
1966年 | 3篇 |
1965年 | 3篇 |
排序方式: 共有1450条查询结果,搜索用时 15 毫秒
51.
52.
53.
Sonia Franciosi PhD Yaein Shim BSc Margaret Lau BCom Michael R. Hayden MB ChB PhD Blair R. Leavitt MD CM 《Movement disorders》2013,28(14):1987-1994
Treatment effect in Huntington disease (HD) clinical trials has relied on primary outcome measures such as total motor score or functional rating scales. However, these measures have limited sensitivity, particularly in pre‐ to early stages of the disease. We performed a systematic review of HD clinical studies to identify endpoints that correlate with disease severity. Using standard HD keywords and terms, we identified 749 published studies from 1993 to 2011 based on the availability of demographic, biochemical, and clinical measures. The average and variability of each measure was abstracted and stratified according to pre‐far, pre‐close, early, mild, moderate, and severe HD stages. A fixed‐effect meta‐analysis on selected variables was conducted at various disease stages. A total of 1,801 different clinical variables and treatment outcomes were identified. Unified Huntington Disease Rating Scale (UHDRS) Motor, UHDRS Independence, and Trail B showed a trend toward separation between HD stages. Other measures, such as UHDRS Apathy, Verbal Fluency, and Symbol Digit, could only distinguish between pre‐ and early stages of disease and later stages, whereas other measures showed little correlation with increasing HD stages. Using cross‐sectional data from published HD clinical trials, we have identified potential endpoints that could be used to track HD disease progression and treatment effect. Longitudinal studies, such as TRACK‐HD, are critical for assessing the value of potential markers of disease progression for use in future HD therapeutic trials. A list of variables, references used in this meta‐analysis, and database is available at http://www.cmmt.ubc.ca/research/investigators/leavitt/publications . © 2013 International Parkinson and Movement Disorder Society 相似文献
54.
Caporale CM Capasso M Lucani M Gandolfi P De Angelis MV Di Muzio A Caporale V Uncini A . 《Journal of the peripheral nervous system : JPNS》2004,9(2):114-115
Campylobacter jejuni (C. jejunj) infection is the most common antecedent in the axonal variant of Guillain‐Barré syndrome (GBS). Antibodies against nerve gangliosides found in GBS patients recognize cross‐reactive epitopes in the lipopolysaccharide (LPS) of C. jejuni. This led to the molecular mimicry hypothesis of GBS. We immunized eleven rabbits with a LPS extracted from HS:19 C. jejuni strain isolated from a patient with GBS and complete Freund's adjuvant (CFA)(group I). In a second experiment we immunized seven rabbits with LPS, CFA and keyhole limpet hemocyanin (KLH)(group II). All group I rabbits developed high titers of anti‐LPS, anti‐GM1, anti‐GD1b antibodies and lower titers of anti‐GD1a. One rabbit, 50 days after initial inoculation, showed tremor and weakness. All rabbits of group II developed high titres of antiganglioside antibodies and six animals showed weakness 59–113 days after initial inoculation. Two rabbits died. Pathology showed mild to moderate, tendentially grouped, axonal degeneration in sciatic nerves of four out of five animals. Control rabbits of group I (immunized with CFA only) did not develop antibodies, controls of group II (immunized with CFA + KLH) developed low titers of IgG anti‐GM1. None developed neurological signs or showed axonal degeneration. C. jejuni LPS is a potent B‐cell stimulator capable to induce a strong antiganglioside response in rabbits. However, to induce the neuropathy is crucial to employ KLH, a glycoprotein known to stimulate both humoral and cellular responses. This animal model reproduces the pathogenetic process hypothesized in axonal GBS with antiganglioside antibodies post C. jejuni infection. 相似文献
55.
CM Pirkle C Boileau V-K Nguyen N Machouf S Ag-Aboubacrine PA Niamba J Drabo S Koala C Tremblay S Rashed 《HIV medicine》2009,10(3):152-156
Objective
This study explores whether viral load measurements can be used in resource‐limited settings to target those in need of adherence assistance. It was hypothesized that high plasma viral loads (pVLs) (≥500 HIV‐1 RNA copies/mL) were the result of poor antiretroviral therapy adherence and amenable to improvement with adherence assistance.Design
A single‐arm, multicentre pilot study was conducted from November 2003 to March 2004 on 606 treatment‐experienced patients who had initiated an antiretroviral regimen in Mali and Burkina Faso ≥6 months before study enrolment. In these patients, those whose pVL was ≥500 copies/mL were offered 1 month of modified directly administered antiretroviral treatment (mDAART) with weekly follow‐up visits from pharmacists or adherence counsellors.Methods
An adherence questionnaire was given to all cohort patients and viral load was used to screen for patients with ≥500 copies/mL. mDAART participants included cohort patients with ≥500 copies/mL, who completed the adherence questionnaire. Genotypic analyses were conducted on samples taken prior to and after the intervention. The intervention was considered effective when there was a decrease of ≥1 log10 in pVL.Results
mDAART was effective in over one‐third of the intervention participants, while in two‐thirds no decrease in pVL was observed. The majority of mDAART participants had major resistance mutations.Conclusions
pVL measurement was useful to identify patients who needed adherence assistance. However, because it was performed ≥6 months after starting treatment, mDAART came too late for most participants, as they had already developed important resistance mutations that might have been avoided with better laboratory monitoring. 相似文献56.
57.
58.
Detection of the Philadelphia chromosome in acute lymphoblastic leukemia by pulsed-field gel electrophoresis 总被引:1,自引:0,他引:1
The Philadelphia (Ph1) chromosome is an acquired abnormality in the malignant cells of 10% to 25% of patients with acute lymphoblastic leukemia (ALL). Unlike chronic myelogenous leukemia (CML), where the molecular detection of the Ph1 chromosome is relatively straightforward using conventional Southern hybridization analysis, the detection of the Ph1 chromosome in ALL is complicated by the existence of several molecular subtypes, and the fact that translocation breakpoints are dispersed over a large genomic area. To circumvent these difficulties, we investigated pulsed-field gel electrophoresis (PFGE) to determine if this method could be used directly on clinical samples to detect the Ph1 chromosome in ALL. We report that, in a study of seven patients with Ph1-positive ALL, we could easily detect the Ph1 using only a single PFGE analysis, regardless of the Ph1 subtype, and we could confirm that the translocations occur either within or very near the BCR gene in all seven. We conclude that PFGE is a useful technique for the detection of the Ph1 in ALL, which ultimately may find wide applicability in the detection of other chromosomal abnormalities in other malignancies. 相似文献
59.
Ajit Singh Lalit Kumar Gupta Ashok Kumar Khare Asit Mittal CM Kuldeep Manisha Balai 《Indian journal of dermatology》2015,60(5):479-484
Background:
The spectrum of pyoderma changes constantly, and so does the antibiotic susceptibility pattern.Aims:
This study was done to assess the magnitude and clinical patterns of pyodermas, their causative micro-organisms, and the antibiotic susceptibility patterns.Materials and Methods:
Five hundred consecutive, clinically diagnosed and untreated cases of pyoderma, attending the Dermatology OPD of RNT Medical College and MB Government Hospital, Udaipur, from October 2010 to September 2011 were the subjects of this study. A detailed clinical examination, and relevant investigations including bacterial culture and sensitivity, were carried out and recorded.Statistical Analysis:
For statistical analysis of data, the software ‘EPI-INFO Version 6’ was used, and Chi-square (χ2) test was applied.Results:
Of 19576 cases attending skin OPD during the study period, pyoderma was seen in 500 patients; the incidence being 2.55%. Males outnumbered females. The highest number of cases (109; 21.8%) was observed in 1st decade. Lower extremities were the commonest site of predilection. Primary pyodermas outnumbered secondary pyodermas. Furuncle (136; 27.2%) and infectious eczematoid dermatitis (62; 12.4%) were the commonest entities among primary and secondary pyoderma respectively. Staphylococcus aureus was the commonest causative agent in both primary and secondary pyoderma. It showed high susceptibility to amoxycillin + sulbactam, aminoglycosides and cefoperazone, moderate susceptibility to linezolid, while low susceptibility to fluoroquinolones and cephalexin.Conclusion:
Such studies help to assess the changing trend of bacterial infections, their causative organisms and antibiotic susceptibility pattern. 相似文献60.
Cleusa P Ferri Sandro S Mitsuhiro Marina CM Barros Elisa Chalem Ruth Guinsburg Vikram Patel Martin Prince Ronaldo Laranjeira 《BMC public health》2007,7(1):209