全文获取类型
收费全文 | 909篇 |
免费 | 51篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 25篇 |
妇产科学 | 12篇 |
基础医学 | 140篇 |
口腔科学 | 12篇 |
临床医学 | 65篇 |
内科学 | 239篇 |
皮肤病学 | 8篇 |
神经病学 | 84篇 |
特种医学 | 29篇 |
外科学 | 137篇 |
综合类 | 7篇 |
一般理论 | 2篇 |
预防医学 | 46篇 |
眼科学 | 1篇 |
药学 | 80篇 |
中国医学 | 4篇 |
肿瘤学 | 71篇 |
出版年
2023年 | 5篇 |
2022年 | 21篇 |
2021年 | 22篇 |
2020年 | 9篇 |
2019年 | 12篇 |
2018年 | 15篇 |
2017年 | 8篇 |
2016年 | 16篇 |
2015年 | 19篇 |
2014年 | 29篇 |
2013年 | 15篇 |
2012年 | 43篇 |
2011年 | 49篇 |
2010年 | 38篇 |
2009年 | 35篇 |
2008年 | 40篇 |
2007年 | 43篇 |
2006年 | 50篇 |
2005年 | 44篇 |
2004年 | 59篇 |
2003年 | 34篇 |
2002年 | 31篇 |
2001年 | 32篇 |
2000年 | 20篇 |
1999年 | 18篇 |
1998年 | 9篇 |
1997年 | 4篇 |
1996年 | 7篇 |
1995年 | 8篇 |
1992年 | 20篇 |
1991年 | 14篇 |
1990年 | 9篇 |
1989年 | 24篇 |
1988年 | 17篇 |
1987年 | 13篇 |
1986年 | 23篇 |
1985年 | 15篇 |
1984年 | 11篇 |
1983年 | 9篇 |
1980年 | 3篇 |
1979年 | 8篇 |
1978年 | 4篇 |
1976年 | 3篇 |
1974年 | 4篇 |
1972年 | 5篇 |
1970年 | 7篇 |
1969年 | 7篇 |
1968年 | 4篇 |
1967年 | 10篇 |
1966年 | 3篇 |
排序方式: 共有966条查询结果,搜索用时 15 毫秒
51.
Luwor RB Zhu HJ Walker F Vitali AA Perera RM Burgess AW Scott AM Johns TG 《Oncogene》2004,23(36):6095-6104
Mutations of the epidermal growth factor receptor (EGFR) gene are found at a relatively high frequency in glioma, with the most common being the de2-7 EGFR (or EGFRvIII). This mutation arises from an in-frame deletion of exons 2-7, which removes 267 amino acids from the extracellular domain of the receptor. Despite being unable to bind ligand, the de2-7 EGFR is constitutively active and imparts a significant in vivo growth advantage to glioma cells. In order to examine the signalling pathways activated by the de2-7 EGFR and its biological effects in an in vitro system, the de2-7 EGFR gene was transfected into the murine IL-3-dependent pro-B-cell line BaF/3. Expression of the de2-7 EGFR enhanced the survival of BaF/3 cells in the absence of IL-3 by reducing apoptosis in a phosphatidylinositol 3-kinase (PI3-K)-dependent manner. Interestingly, while de2-7 EGFR also enhanced proliferation of BaF/3 cells in low levels of IL-3, this effect was independent of PI3-K. Survival and proliferation were further enhanced when BaF/3 cells were cotransfected with the de2-7 and wt EGFR. This was due to heterodimerization between the de2-7 and wt EGFR leading to trans-phosphorylation of the wt EGFR. This observation is directly relevant to glioma where de2-7 and wt EGFR appear to be coexpressed. Thus, expression of de2-7 EGFR in BaF/3 cells provides an in vitro model for evaluating the signalling pathways activated by this receptor. 相似文献
52.
Vitali P Nobili F Raiteri U Canfora M Rosa M Calvini P Girtler N Regesta G Rodriguez G 《Psychiatry research》2004,130(1):97-107
This article describes the unusual case of a 60-year-old woman suffering from pure progressive aphemia. The fusion of multimodal neuroimaging (MRI, perfusion SPECT) implicated the right frontal lobe, especially the inferior frontal gyrus. This area also showed the greatest functional MRI activation during the performance of a covert phonemic fluency task. Results are discussed in terms of bihemispheric language representation. The fusion of three sets of neuroimages has aided in the interpretation of the patient's cognitive brain dysfunction. 相似文献
53.
Vaccination of persons allergic to latex: a review of safety data in the Vaccine Adverse Event Reporting System (VAERS) 总被引:1,自引:0,他引:1
Vaccine products currently licensed in the US and other countries are marketed in vials and syringes that may contain natural latex allergens. Little scientific information exists regarding the safety of vaccination of latex-allergic individuals. A review of data within the Vaccine Adverse Event Reporting System (VAERS), a large registry of reported possible vaccine adverse reactions was conducted. A search of the database, which contains >160,000 vaccine adverse event reports, revealed only 28 cases of possible immediate-type hypersensitivity reactions in vaccine recipients with a history of allergy to latex. Given the large number of immunizations administered every year in the US, the reported risk of allergic reactions possibly due to latex contamination of vaccines appears to be very small. 相似文献
54.
Longhi A Macchiagodena M Vitali G Bacci G 《Journal of pediatric hematology/oncology》2003,25(4):292-296
PURPOSE: To evaluate fertility in male patients with osteosarcoma after chemotherapy including high doses of alkylating agents. PATIENTS AND METHODS: Postchemotherapy fertility was evaluated in 96 male patients who received chemotherapy at the authors' institution from 1976 to 1996 for localized bone osteosarcoma of the extremities. Four drugs were administrated (doxorubicin, cisplatin, methotrexate, ifosfamide) at different doses according to six different protocols. Eleven patients were prepubertal and 85 were postpubertal at the time of chemotherapy. The median age of these patients at the time of chemotherapy was 17 years (range 10-42), the median age at the time of the interview was 27 years (range 19-53), and the median follow-up from the end of chemotherapy was 9 years (range 4-17). RESULTS: Of the 96 patients, 26 underwent sperm analysis and 20 showed oligo- or azoospermia. Patients who received high-dose ifosfamide showed a higher incidence of azoospermia. Six patients were normospermic and received no ifosfamide or lower doses of ifosfamide. Eight patients fathered a total of 12 children. No birth defects or congenital anomalies were observed in their offspring. CONCLUSIONS: The rate of sterility was related to ifosfamide dosage. It appears that pubertal maturation is not affected by chemotherapy. No congenital malformations were seen in the children of the few patients who fathered children. 相似文献
55.
Mudu P Migliore G Alderisio M Morosini P Douglas G Navone R Montanari G Di Bonito L Vitali A Moretti D Giovagnoli MR Fulciniti F Branca M Vitale A;National Institute of Health Coordinating Group 《European journal of gynaecological oncology》2002,23(3):211-215
OBJECTIVE: The main objective was to assess the sensitivity, specificity and reliability of PAPNET-assisted diagnosis in comparison with conventional screening. SETTING: Seven Italian and one English University or Research Institutes, and a random sample of an other 20 Italian Laboratories of the Italian National Health Service (INHS) provided the cervical smears. METHODS: During the training phase every center examined in rotation four sets of slides for a total of 300 representative slides. Afterwards, 900 "positive" slides were added to the 3,100 slides which were collected consecutively without any selection or exclusion. The eight main centers were divided into four couples and each couple of centers examined 775 slides with the PAPNET system, "blindly" to the original diagnosis. An expert cytopathologist (M.A.) of the National Institute of Health (NIH) reassessed 40% of the slides with an original negative diagnosis to evaluate the false negative rate. Two expert NIH cytopathologists (M.A., G.M.) re-examined all slides where a disagreement had been observed between the original and one or both of the study diagnoses. The main analyses concerned the following three main categories: WNL and unsatisfactory for evaluation; ASCUS, AGUS and LSIL; HSIL and carcinoma. A special algorithm was devised to define the reference diagnosis for sensitivity and specificity assessment. RESULTS: Laboratories, even belonging to the same couple, classified as "no review" a very different proportion of slides ranging from 35% to 74%. The index of kappa agreement between the members of couples examining the same sets of slides was low or very low, ranging from 0.30 to 0.03. The sensitivity of the review classification was particularly low in some laboratories. Surprisingly, only a small correlation was observed between the sensitivity of the review classification and the proportion of slides classified as "review". The "tentative" diagnosis on PAPNET tiles of the "review" slides was almost as reliable as the microscopic diagnosis. In the overall performance, there were many significant differences among the eight laboratories. The best laboratory had a sensitivity of 95% and a specificity of 96%. At least three laboratories displayed unacceptably low sensitivity and one a very low specificity. CONCLUSION: Altogether these results seem to confirm that there are wide differences among cytological laboratories per se, and that these differences are intensified by the use of an instrument like PAPNET. The huge variation in performance may be explained by differences in basic skills and by different training, but it is difficult to understand exactly what could have been done to reduce it. 相似文献
56.
Zampaloni C Vitali LA Prenna M Toscano MA Tempera G Ripa S 《Microbial drug resistance (Larchmont, N.Y.)》2002,8(1):39-44
Erythromycin resistance among Streptococcus pyogenes strains has been reported in Italy at high rates during the last few years. A total of 152 erythromycin-resistant isolates of this species from southern Italian regions were characterized for the macrolide-resistance phenotype and screened by PCR for the corresponding genetic determinant. A close correlation was found between these phenotypic/genotypic data concerning macrolide resistance and results of Sma I macrorestriction fragment patterns (PFGE) analysis. In fact, the vast majority of the isolates assigned to individual PFGE classes mostly belonged to a single phenotype of macrolide resistance. All untypeable isolates belonged to the M phenotype. Twenty-two distinct PFGE types were recognized, of which 11 were recorded in only one isolate (one-strain type); about 50% of typeable isolates fell into five type clusters and 70% in seven. The increased erythromycin resistance among Italian isolates of S. pyogenes does not appear to be due to the spread of a single clone, but results indicate that the majority of group A streptococci examined are probably spread from a limited number of clones. 相似文献
57.
Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group 总被引:2,自引:0,他引:2
下载免费PDF全文
![点击此处可从《Annals of the rheumatic diseases》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Vitali C Bombardieri S Jonsson R Moutsopoulos HM Alexander EL Carsons SE Daniels TE Fox PC Fox RI Kassan SS Pillemer SR Talal N Weisman MH;European Study Group on Classification Criteria for Sjögren's Syndrome 《Annals of the rheumatic diseases》2002,61(6):554-558
Classification criteria for Sj?gren's syndrome (SS) were developed and validated between 1989 and 1996 by the European Study Group on Classification Criteria for SS, and broadly accepted. These have been re-examined by consensus group members, who have introduced some modifications, more clearly defined the rules for classifying patients with primary or secondary SS, and provided more precise exclusion criteria. 相似文献
58.
Moraschini F Vitali V Togni I Riboli B Marchesi G Fumagalli R 《Minerva anestesiologica》2003,69(4):320-323
ICU nurses hold an important role in the management of septic patients underlining with their ability to recognize SIRS that is the first step in the proinflammatory and procoagulant cascade following an infection. Early and timely approach to organ dysfunction can indeed modify the damages due to hypoperfusion. The ability to recognize organ dysfunction using different monitoring devices available should be part of the nursing attitudes. 相似文献
59.
Dalpiaz A Vertuani G Scatturin A Vitali F Varani K Spisani S 《Arzneimittel-Forschung》2003,53(11):793-798
The conformation of several Met-Ile-Phe-Leu analogues was analyzed using circular dichroism and infra-red absorption. Their effect on human neutrophils was verified by receptor binding assays and measurements of lysozyme release. The results demonstrate that in amphipatic environments the compounds examined can be highly and weakly ordered in beta-turn structures, in dependence on their N-terminal substituents. The ability of the compounds to evoke neutrophil functions appears strongly and weakly influenced by N- and C-terminal modification, respectively. 相似文献
60.
G. Rodriguez C. De Leo N. Girtler P. Vitali E. Grossi F. Nobili 《Neurological sciences》2003,24(5):329-335
Abstract.
A survey in the cities of Genoa and Savona (Italy) was
performed to examine stress levels in caregivers of patients
with Alzheimers disease in the context of a project of the
Italian Ministry of Health named Cronos. It offered free
anticholinesterase inhibitor therapy to patients who addressed
dedicated Neurological Units; in this occasion caregivers could
be invited to express the main difficulties encountered in
managing demented people during an interview conducted by health
personnel of the Neurophysiology Service. Caregivers were mainly
women, daughters or spouses, with a medium educational level,
retired, housekeepers, employees or teachers; they claimed a
lowering of economic standard of living of the family owing to
extra expenses for assistance. Satisfaction was expressed
towards specialists, while support by general practitioners and
other sanitary services was usually lacking and money
contribution from the government or territorial services was
considered inadequate. From the emotional point of view,
caregivers claim loss of free time, friendships and hobbies, and
feel isolated in the social context; sometimes the patients
death is thought of as a solution. A strong need for information
and support is clearly emerging and any further interventions
should take these requirements into consideration. 相似文献