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991.
992.
993.
HLA class II genotypic frequencies in atopic asthma: association of DRB1*01-DQB1*0501 genotype with Artemisia vulgaris allergic asthma 总被引:1,自引:0,他引:1
Torío A Sánchez-Guerrero I Muro M Villar LM Minguela A Marín L Moya-Quiles MR Montes-Ares O Pagán J Alvarez-López MR 《Human immunology》2003,64(8):811-815
Different human leukocyte antigen (HLA) class II alleles have been associated with the development of atopic asthma. To determine whether HLA class II alleles are associated with atopic asthma in a population from southeast Spain (Murcia region), 213 atopic asthmatic patients and 150 controls were selected for HLA typing. Significant association of the DRB1*01 and DQB1*0501 alleles was found in Artemisia vulgaris allergic patients (p(c) = 0.00052 and p(c) = 0.00023, respectively). No significant correlation was found in other atopic patients allergic to pollens (Phleum pratense, Olea europaea, and Salsola kali), house dust mites (Dermatophagoides pteronyssinus, D. farinae), molds (Alternaria alternata, Cladosporium herbarum), or animal danders (dog, cat). The results reveal that the DRB1*01-DQB1*0501 genotype is strongly associated with a positive response to Artemisia vulgaris in the population studied. 相似文献
994.
Somatic mutations are frequent and increase with age in human kidney epithelial cells 总被引:6,自引:0,他引:6
Martin GM; Ogburn CE; Colgin LM; Gown AM; Edland SD; Monnat RJ Jr 《Human molecular genetics》1996,5(2):215-221
We have used a primary cloning assay to determine the frequency of 6-
thioguanine (TG)-resistant tubular epithelial cells in kidney tissue from
72 human donors ranging in age from 2 to 94 years. The frequency of
TG-resistant mutants ranged from approximately 5 x 10(-5) for donors in the
first decade of life to approximately 2.5 x 10(-4) for donors in the eighth
and later decades of life. Two different statistical analyses indicated
that this increase in mutant frequency is exponential with age. We also
observed a 2-fold higher TG-resistant mutant frequency in nephrectomy
kidneys containing a coincident renal carcinoma. DNA sequence analyses
revealed HPRT gene mutations in each of 14 TG-resistant mutants from seven
unrelated donors. Thirteen of these 14 mutants resulted from independent
mutational events. These results suggest that somatic mutations are common
in renal--and perhaps in other human--epithelia, and thus could play an
important role in the genesis of age-associated disease.
相似文献
995.
996.
Rahul Gupta Kumar Gaurav Bajpai Samta Johri AM Saxena 《African journal of traditional, complementary, and alternative medicines》2008,5(1):1-17
Diabetes mellitus is a global metabolic epidemic affecting essential biochemical activities in almost every age group. Indian literatures like Ayurveda have already mentioned herbal remediation for a number of human ailments. Among Indian traditional medicinal plants several potential anti-diabetic plants and herbs are being used as part of our diet since prehistoric time. India has a long list of native medicinal plants with confirmed blood sugar lowering property. Some of these have proved remarkable for cure of diabetes and its complications. The current paper is aimed at providing a review on clinical and experimental studies carried out on the most effective and commonly used hypoglycemic plants and herbs species from traditional Indian flora. This write-up includes hypoglycemic and anti-hyperglycemic activities of plants, active hypoglycemic compounds and constituents along with their available toxicity status. 相似文献
997.
998.
Litvan H Jensen EW Maestre ML Galán J Campos JM Fernández JA Caminal P Villar Landeira JM 《Revista espa?ola de anestesiología y reanimación》2000,47(10):447-457
OBJECTIVES: To evaluate an anesthetic depth index (ADI) obtained from auditory evoked potentials and a bispectral EEG index (BIS) in comparison with clinical assessment of anesthetic depth using the modified observer's assessment of awareness/sedation scale (MOAA/SS), for induction of anesthesia with propofol or sevoflurane as the only agent. PATIENTS AND METHODS: The ADI and BIS were recorded simultaneously in this prospective study and compared to the MOAA/SS during the anesthetic induction of 26 adults undergoing elective heart surgery. Assignment of patients to two groups was random. Group A (n = 13) patients were induced with propofol (target dose 5 micrograms.ml-1 in 5 min). Induction in group B (n = 13) was with sevoflurane (8% tidal volume). A scheme of awake-sleeping-awake-sleeping was followed. The means of the two indexes were compared (Mann-Whitney test) one minute before the patient slept (awake) and one minute later (sleeping), and the evolution of the indexes was compared during awake/sleep and sleep/awake phase changes and while the patients were in a stable sleep phase. The sensitivity and specificity of each index was analyzed in function of the MOAA/SS. We also analyzed the time elapsing from the moment the patient fell asleep (MOAA/SS 2) until the two indexes reached published reference values (ADI = 38, BIS = 60). RESULTS: After induction with propofol (group A) the ADI fell to 29.2 +/- 11.7 and the BIS fell to 63.5 +/- 13.4. After induction with sevoflurane (group B) the ADI fell to 33.8 +/- 14.9 and the BIS to 66.8 +/- 15. The ADI value that best discriminated between arousal and sleeping (sensitivity 100%) was 38; the BIS value that best discriminated was 60. The responses to sound in decibels (dB) during "awake/sleeping" and "sleeping/awake" phases were, respectively, -3.8 dB and -4.5 dB for the ADI and -1.5 dB and -0.8 dB for the BIS. With the patient in stable sleep, response to the two indexes was at -0.79 dB. In group A, the ADI detected MOAA/SS 2 significantly earlier (ADI 13.1 +/- 30 s; BIS 56 +/- 36 s; p < 0.05). No patient reported remembering the study period. CONCLUSIONS: Monitoring anesthetic depth with the ADI or BIS was technically easy and effective for detecting whether patients were awake or sleeping. The ADI response was faster and identified awake/sleeping and sleeping/awake phase changes better than did the BIS. 相似文献
999.
1000.
急性脑梗死患者血小板内钙和TXB2含量与聚集关系的探讨 总被引:1,自引:0,他引:1
目的探讨急性脑梗死急性期患者血小板内游离钙和TXB2含量之间的相互关系及意义。方法 用Fura-2/AM荧光技术测定了46例急性脑梗死患者急性期及25例正常对照组血小板内钙含量,用放射免疫分析法测定其血小板内血栓素B2(TXB2)含量,用比浊法测定其血小板聚集。结果患者血小板内游离Ca2+和TXB2含量均分别明显高于正常对照组(147.26±10.85 vs 119.30±10.94 nmol/L和3.38±0.78vs 4.88±0.97ng/109血小板,P均<0.01);在患者中,低(0.5μmol/L)和高(5μmol/L)浓度二磷酸腺苷(ADP)诱导的血小板聚集均明显高于正常对照组(0.44±0.19vs 0.26±0.14和0.73±0.13vs0.39±0.19,P均<0.01);在患者中血小板内游离Ca2+含量和TXB2含量均分别与5μmol/L二磷酸腺苷诱导的血小板呈明显的正相关性(r分别为0.786和0.593,P均<0.01),而血小板内Ca2+与TXB2成明显的正相关性(r为0.652,P<0.01)。结论 急性脑梗死患者在急性期血小板功能处于活跃状态,可能与其内 Ca2+含量增加、TXB 相似文献