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51.
Urinary Kidney injury molecule‐1 can predict delayed graft function in living donor renal allograft recipients 下载免费PDF全文
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Deepakraj Gajanana Manisha Ganapathi Raikar Pradhum Ram Vikas Bhalla Vincent Figueredo Sean Janzer Jon C. George 《Cardiovascular Revascularization Medicine》2019,20(3):207-209
Introduction
There is scarcity of data validating portable digital ankle-brachial index (ABI) with contrast angiography in peripheral arterial disease (PAD). Our aim was to provide an objective analysis of the relationship between digital ABI (dABI) and peripheral angiographic data.Methods
Consecutive patients with symptoms of PAD between May 2014 to May 2015 at Einstein Medical Center, Philadelphia, who were undergoing simultaneous dABI and peripheral angiography, were evaluated. Measurements were made using the FloChec? Digital ABI system (Bard) prior to the scheduled peripheral angiogram.Results
The final cohort consisted of 51 patients. Mean age was 68.8?±?9.5?years with 55% being male. Aorto-iliac disease accounted for 13% of the total lesions, while femoro-popliteal lesions comprised 55%. The FloChec? digital ABI had a sensitivity of 84% and a positive predictive value of 84%. The area under the receiver operating characteristic curve was 0.74 (p?=?0.007). On multivariate analysis, FloChec? digital ABI was still an independent predictor of PAD, Odds ratio 6.8 (2.3–20.6, p?=?0.001).Conclusion
A portable, point-of-care digital ABI system can be used as a valuable, simple, cost-effective and reliable screening tool with high sensitivity and accuracy. To date, ours is the first study validating FloChec? digital ABI with the gold standard angiographic data. 相似文献54.
Anu Balakrishnan Rohit Aggarwal Vikas Agarwal Latika Gupta 《International journal of rheumatic diseases》2020,23(9):1126-1135
Inclusion body myositis is a rare sporadic inflammatory‐degenerative myopathy of the elderly. Despite being the commonest type of acquired myopathy after the age of 50, misdiagnosis is extremely common. The most frequent hurdle in identifying new cases is the wrong diagnosis of polymyositis or motor neuron disease. Novel insights into pathogenic mechanisms have heralded the quest for newer therapeutics as well as drug repurposing in this otherwise progressive disorder. 相似文献
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Anupama Sharma Dishant Vikas Gupta Jaya Shankar Kaushik Kundan Mittal 《Indian Journal of Critical Care Medicine》2014,18(1):33-36
Background:
Aluminum phosphide (ALP) (celphos) is an agricultural pesticide commonly implicated in poisoning. Literature pertaining to the clinical manifestations and treatment outcome of its poisoning among children is limited.Materials and Methods:
A retrospective chart review was conducted of the medical records of 30 children aged less than 14 years admitted to pediatric intensive care unit (PICU) of a tertiary care hospital in northern India. Demographic, clinical, and laboratory parameters were recorded. The outcome was categorized into “survivors” and “nonsurvivors.”Results:
The Mean (SD) age of the enrolled children [19 males (63.3%)] was 8.55 (3.07) years. Among the 30 children, 14 (46.67%) were nonsurvivors and the rest 16 (53.33%) were survivors. Nonsurvivors had ingested significantly higher doses of ALP (P < 0.001), and showed higher time lag to PICU transfer (P 0.031), presence of abnormal radiological findings on chest skiagram (P = 0.007), and a higher Pediatric Risk of Mortality (PRISM) III score (P < 0.001) at admission. Use of magnesium sulfate was associated significantly with survival [odds ratio (OR) (95% CI): 0.11 (0.02-0.66); P 0.016].Conclusion:
The present study highlights that survival among children with ALP poisoning is predicted by dose of ALP ingestion, time lag to medical attention, and higher PRISM score at admission. Use of magnesium sulfate could be associated with better survival among them. 相似文献56.
Apurva O. Badheka Neeraj Shah Peeyush M. Grover Nileshkumar J. Patel Ankit Chothani Kathan Mehta Vikas Singh Abhishek Deshmukh Ghanshyambhai T. Savani Ankit Rathod Sidakpal S. Panaich Nilay Patel Shilpkumar Arora Vipulkumar Bhalara James O. Coffey Raul D. Mitrani Jonathan L. Halperin Juan F. Viles-Gonzalez 《The American journal of cardiology》2014
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Zalawadiya SK Veeranna V Panaich SS Afonso L Ghali JK 《The American journal of cardiology》2012,109(11):1664-1670
Limited information is available about gender and ethnic differences in red cell distribution width (RCDW) with regard to its relation to mortality in a population free of cardiovascular (CV) disease and diabetes. To assess gender and ethnic differences in RCDW and their effect on the association between RCDW and mortality, the Third National Health and Nutritional Examination Survey (n = 15,460, 1988 to 1994) data were examined. Multivariate adjusted Cox proportional hazard analysis was performed to assess effect of gender and ethnicity on the association between RCDW and mortality (total, CV disease, and coronary heart disease [CHD]). RCDW (mean ± SE) was greater in black women (13.1 ± 0.03) and men (13.4 ± 0.02) compared to women of white (12.9 ± 0.02) and other (13.0 ± 0.07) ethnicities and men of white (13.3 ± 0.02) and other (13.3 ± 0.07) ethnicities, respectively (p <0.001). The interaction between RCDW and gender was statistically significant for all study outcomes (p <0.001) but nonsignificant for RCDW and ethnicity. After adjusting for key variables, RCDW in women was associated with adjusted hazard ratios of 1.22 (95% confidence interval [CI] 1.14 to 1.31) for all-cause mortality, 1.17 (95% CI 1.07 to 1.28) for CV deaths, and 1.18 (95% CI 1.03 to 1.35) for CHD deaths; in men, adjusted hazard ratios were 1.29 (95% CI 1.20 to 1.38) for all-cause mortality, 1.27 (95% CI 1.17 to 1.37) for CV deaths, and 1.25 (95% CI 1.13 to 1.39) for CHD deaths (p <0.05 for all). In conclusion, blacks and men have significantly greater RCDWs compared to whites and women. Greater RCDW is associated with a greater risk of mortality in men compared to women, whereas no effect modification is observed by ethnicity. 相似文献
59.
Background: Red cell distribution width (RDW) and hemoglobin A1c (HbA1c) are both known to be predictive of future cardiovascular disease (CVD). Objective: We hypothesized that RDW would be associated with HbA1c in adults without diabetes independent of fasting blood glucose (FBG). Methods: This cross-sectional study included 15,343 nondiabetic adults, free of CVD, enrolled in NHANES 1999-2008. Adjusted means of RDW were calculated across HbA1c categories for the overall population. Multivariable regression analyses were performed analyzing the association between RDW and HbA1c for individuals with available data on FBG (n = 7,454). Results: RDW significantly correlated with HbA1c (r = 0.27, p < 0.001; n = 15,343), with a gradual increase in adjusted mean RDW across HbA1c categories (12.59% ± 0.02% in the group with HbA1c ≤4.8% vs. 12.92% ± 0.02% in the group with HbA1c >5.8%, p < 0.001 for trend). In regression analyses, RDW independently predicted HbA1c (β-coefficient 0.034, 95% CI 0.026-0.042, p < 0.001). Conclusion: RDW significantly predicts HbA1c independent of FBG in healthy nondiabetic adults, suggesting the possibility of chronic hyperglycemia mediating the association between RDW and CVD. 相似文献
60.
Abdel-Wahab O Pardanani A Bernard OA Finazzi G Crispino JD Gisslinger H Kralovics R Odenike O Bhalla K Gupta V Barosi G Gotlib J Guglielmelli P Kiladjian JJ Noel P Cazzola M Vannucchi AM Hoffman R Barbui T Thiele J Van Etten RA Mughal T Tefferi A 《American journal of hematology》2012,87(5):562-568
Immediately after the annual scientific meeting of the American Society of Hematology (ASH), a select group of clinical and laboratory investigators in myeloproliferative neoplasms (MPN) is summoned to a post-ASH conference on chronic myeloid leukemia and the BCR-ABL1-negative MPN. The 6th such meeting occurred on December 13–14,2011, in La Jolla, California, USA, under the direction of its founder,Dr. Tariq Mughal. The current document is the first of two reports on this post-ASH event and summarizes the most recent preclinical and clinical advances in polycythemia vera, essential thrombocythemia,and primary myelofibrosis. 相似文献