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排序方式: 共有1608条查询结果,搜索用时 15 毫秒
61.
Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis 总被引:4,自引:0,他引:4
Johansson A Marroni F Hayward C Franklin CS Kirichenko AV Jonasson I Hicks AA Vitart V Isaacs A Axenovich T Campbell S Dunlop MG Floyd J Hastie N Hofman A Knott S Kolcic I Pichler I Polasek O Rivadeneira F Tenesa A Uitterlinden AG Wild SH Zorkoltseva IV Meitinger T Wilson JF Rudan I Campbell H Pattaro C Pramstaller P Oostra BA Wright AF van Duijn CM Aulchenko YS Gyllensten U;EUROSPAN Consortium 《Human molecular genetics》2009,18(2):373-380
62.
Liu Shuling Matthew Lau Sie Kuei Seyed Ehsan Saffari Zheng Jiayun Tan Tse Yeun Jessie Phoon Wai Leng Veronique Viardot-Foucault Sadhana Nadarajah Jerry Kok Yen Chan Tan Heng Hao 《Reproductive biomedicine online》2019,38(1):39-45
Research question
Previous studies of aromatase inhibitors on male infertility have focused on men with low testosterone–oestradiol ratio of less than 10. Can aromatase inhibitors improve spermatogenesis in men with idiopathic male infertility with normal testosterone–oestradiol ratio?Design
Prospective study of men with idiopathic severe oligozoospermia (sperm concentration <5 million/ml) carried out between February 2015 and March 2017. The objective was to assess if semen-analysis parameters improved after treatment with letrozole. Secondary objectives were to monitor the safety of letrozole in men, and to measure the alterations in serum FSH, LH, oestradiol and testosterone levels.Results
Fifteen men with normal testosterone–oestradiol ratio (>10) were treated with letrozole 2.5 mg daily for 4 months. This produced a 5.5-fold increase in sperm concentration (P?=?0.0068). All men had increased total serum testosterone and suppressed oestradiol levels after treatment, thus raising the overall testosterone–oestradiol ratio (P < 0.0001). Adverse effects from letrozole were relatively minor and included loss of libido (54%), headaches (25%), fatigue (21%), weakness (13%), loss of hair (8%) and dry mouth (8%).Conclusions
Letrozole improves sperm concentration and increases testosterone–oestradiol ratio for men with oligozoospermia who have normal testosterone–oestradiol ratio; its role in the treatment of male infertility may be extended to this group of patients. In addition, it is a relatively well-tolerated drug with no serious adverse effects. 相似文献63.
64.
Lieve Peremans Veronique Verhoeven Hilde Philips Joke Denekens Paul Van Royen 《The European journal of contraception & reproductive health care》2007,12(4):317-325
OBJECTIVE: To evaluate how Belgian health care providers deal with a request for emergency contraception. METHOD: In 2002-2003 we conducted 12 focus groups with pharmacists, general practitioners and school physicians. A skilled moderator accompanied by an observer conducted the focus groups using a semi-structured screenplay. RESULTS: All these health care providers agree with the free access to emergency contraception (EC), but experience considerable frustration with regard to the practical aspects and the legal framework. General practitioners (GPs) claim to spend a lot of time on requests for EC and they are concerned about the quality of the counselling provided in pharmacies. Pharmacists are creative when giving counselling in the pharmacy, but there is, nevertheless, a problem with a lack of privacy. School physicians are frustrated that there is no legal possibility to respond to a request for EC when they feel they are ideally placed to advise adolescents. CONCLUSION: The over-the-counter sale of EC offers women better access, but many barriers still interfere with optimal care. Pharmacists experience a lack of skills to communicate with adolescents and a lack of privacy to give counselling. GPs have good intentions, but are confronted with a lack of willingness on the part of the patients and also financial barriers. School physicians want more possibilities to help adolescents. 相似文献
65.
Vincenzo Cerundolo Adam Benham Veronique Braud Siddhartha Mukherjee Keith Gould Beatrice Macino Jacques Neefjes Alain Townsend 《European journal of immunology》1997,27(1):336-341
We describe the effect of the proteasome specific inhibitor lactacystin on the metabolic stability of influenza nucleoprotein (NP) and on the generation of antigens presented by human and murine class I molecules of the major histocompatibility complex to cytotoxic T lymphocytes (CTL). We show that cells treated with lactacystin fail to present influenza antigens to influenza-specific CTL, but retain the capacity to present defined epitopes expressed as peptides intracellularly by recombinant vaccinia viruses. This block in antigen presentation can be overcome by expressing the viral protein within the lumen of the endoplasmic reticulum, confirming the specificity of lactacystin for cytosolic proteases. We also show that the effect of lactacystin on antigen presentation correlates with the block of breakdown of a rapidly degraded form of the influenza NP linked to ubiquitin. These results demonstrate that proteasome-dependent degradation plays an important role in the cytosolic generation of CTL epitopes. 相似文献
66.
M. Faina V. Billat R. Squadrone M. De Angelis J. P. Koralsztein A. Dal Monte 《European journal of applied physiology》1997,76(1):13-20
Using 23 elite male athletes (8 cyclists, 7 kayakists, and 8 swimmers), the contribution of the anaerobic energy system to the time to exhaustion (t lim) at the minimal exercise intensity (speed or power) at which maximal oxygen uptake (V˙O2 max) occurs (I V˙O2 max) was assessed by analysing the relationship between the t lim and the accumulated oxygen deficit (AOD). After 10-min warming up at 60% of V˙O2 max, the exercise intensity was increased so that each subject reached his I V˙O2max in 30?s and then continued at that level until he was exhausted. Pre-tests included a continuous incremental test with 2?min steps for determining the I V˙O2max and a series of 5-min submaximal intensities to collect the data that would allow the estimation of the energy expenditure at I V˙O2max . The AOD for the t lim exercise was calculated as the difference between the above estimation and the accumulated oxygen uptake. The mean percentage value of energy expenditure covered by anaerobic metabolism was 15.2 [(SD 6)%, range 8.9–24.1] with significant differences between swimmers and kayakists (16.8% vs 11.5%, P≤0.05) and cyclists and kayakists (16.4% vs 11.5%, P≤0.05). Absolute AOD values ranged from 26.4?ml?·?kg?1 to 83.6?ml?·?kg?1 with a mean value of 45.9 (SD 18)?ml?·?kg?1. Considering all the subjects, the t lim was found to have a positive and significant correlation with AOD (r?=?0.62, P≤0.05), and a negative and significant correlation with V˙O2 max (r?=??0.46, P≤0.05). The data would suggest that the contribution of anaerobic processes during exercise performed at I V˙O2max should not be ignored when t lim is used as a supplementary parameter to evaluate specific adaptation of athletes. 相似文献
67.
Tracy A. Briggs Gillian I. Rice Navid Adib Lesley Ades Stephane Barete Kannan Baskar Veronique Baudouin Ayse N. Cebeci Philippe Clapuyt David Coman Lien De Somer Yael Finezilber Moshe Frydman Ayla Guven Sébastien Heritier Daniela Karall Muralidhar L. Kulkarni Pierre Lebon David Levitt Martine Le Merrer Agnes Linglart John H. Livingston Vincent Navarro Ericka Okenfuss Anne Puel Nicole Revencu Sabine Scholl-Bürgi Marina Vivarelli Carine Wouters Brigitte Bader-Meunier Yanick J. Crow 《Journal of clinical immunology》2016,36(3):220-234
Purpose
Spondyloenchondrodysplasia is a rare immuno-osseous dysplasia caused by biallelic mutations in ACP5. We aimed to provide a survey of the skeletal, neurological and immune manifestations of this disease in a cohort of molecularly confirmed cases.Methods
We compiled clinical, genetic and serological data from a total of 26 patients from 18 pedigrees, all with biallelic ACP5 mutations.Results
We observed a variability in skeletal, neurological and immune phenotypes, which was sometimes marked even between affected siblings. In total, 22 of 26 patients manifested autoimmune disease, most frequently autoimmune thrombocytopenia and systemic lupus erythematosus. Four patients were considered to demonstrate no clinical autoimmune disease, although two were positive for autoantibodies. In the majority of patients tested we detected upregulated expression of interferon-stimulated genes (ISGs), in keeping with the autoimmune phenotype and the likely immune-regulatory function of the deficient protein tartrate resistant acid phosphatase (TRAP). Two mutation positive patients did not demonstrate an upregulation of ISGs, including one patient with significant autoimmune disease controlled by immunosuppressive therapy.Conclusions
Our data expand the known phenotype of SPENCD. We propose that the OMIM differentiation between spondyloenchondrodysplasia and spondyloenchondrodysplasia with immune dysregulation is no longer appropriate, since the molecular evidence that we provide suggests that these phenotypes represent a continuum of the same disorder. In addition, the absence of an interferon signature following immunomodulatory treatments in a patient with significant autoimmune disease may indicate a therapeutic response important for the immune manifestations of spondyloenchondrodysplasia.68.
Testing genotypic and phenotypic resistance in human immunodeficiency virus type 1 isolates of clade B and other clades from children failing antiretroviral therapy 总被引:5,自引:0,他引:5 下载免费PDF全文
69.
Enterohemorrhagic Escherichia coli infection induces interleukin-8 production via activation of mitogen-activated protein kinases and the transcription factors NF-kappaB and AP-1 in T84 cells 下载免费PDF全文
Dahan S Busuttil V Imbert V Peyron JF Rampal P Czerucka D 《Infection and immunity》2002,70(5):2304-2310
70.
Circulating CD26 is negatively associated with inflammation in human and experimental arthritis 下载免费PDF全文
Busso N Wagtmann N Herling C Chobaz-Péclat V Bischof-Delaloye A So A Grouzmann E 《The American journal of pathology》2005,166(2):433-442
Dipeptidyl peptidase IV (DPPIV, CD26), a protease-cleaving N-terminal X-Pro dipeptide from selected proteins including some chemokines, is expressed both as a soluble form in plasma and on the cell surface of various immune and nonimmune cell types. To gain insights into the pathophysiological role of CD26 in arthritis, we explored DPPIV/CD26 expression during murine antigen-induced arthritis (AIA), an experimental model of arthritis. AIA induction led to reduced plasma DPPIV activity. In CD26-deficient mice, the severity of AIA was increased as assessed by enhanced technetium uptake and by increased histological parameters of inflammation (synovial thickness and exudate). We demonstrated that CD26 controls the in vivo half-life of the intact active form of the proinflammatory chemokine stromal cell-derived factor-1 (SDF-1). CD26-deficient mice exhibited increased levels of circulating active SDF-1, associated with increased numbers of SDF-1 receptor (CXCR4)-positive cells infiltrating arthritic joints. In a clinical study, plasma levels of DPPIV/CD26 from rheumatoid arthritis patients were significantly decreased when compared to those from osteoarthritis patients and inversely correlate with C-reactive protein levels. In conclusion, decreased circulating CD26 levels in arthritis may influence CD26-mediated regulation of the chemotactic SDF-1/CXCR4 axis. 相似文献