全文获取类型
收费全文 | 1275篇 |
免费 | 64篇 |
国内免费 | 148篇 |
专业分类
儿科学 | 60篇 |
妇产科学 | 63篇 |
基础医学 | 124篇 |
口腔科学 | 18篇 |
临床医学 | 167篇 |
内科学 | 286篇 |
皮肤病学 | 30篇 |
神经病学 | 57篇 |
特种医学 | 316篇 |
外科学 | 53篇 |
综合类 | 24篇 |
预防医学 | 45篇 |
眼科学 | 13篇 |
药学 | 116篇 |
1篇 | |
肿瘤学 | 114篇 |
出版年
2023年 | 3篇 |
2022年 | 1篇 |
2021年 | 4篇 |
2020年 | 4篇 |
2019年 | 9篇 |
2018年 | 16篇 |
2017年 | 12篇 |
2016年 | 18篇 |
2015年 | 15篇 |
2014年 | 21篇 |
2013年 | 37篇 |
2012年 | 30篇 |
2011年 | 34篇 |
2010年 | 43篇 |
2009年 | 49篇 |
2008年 | 29篇 |
2007年 | 122篇 |
2006年 | 31篇 |
2005年 | 37篇 |
2004年 | 23篇 |
2003年 | 27篇 |
2002年 | 36篇 |
2001年 | 38篇 |
2000年 | 36篇 |
1999年 | 27篇 |
1998年 | 82篇 |
1997年 | 79篇 |
1996年 | 73篇 |
1995年 | 62篇 |
1994年 | 43篇 |
1993年 | 52篇 |
1992年 | 13篇 |
1991年 | 25篇 |
1990年 | 16篇 |
1989年 | 53篇 |
1988年 | 35篇 |
1987年 | 33篇 |
1986年 | 25篇 |
1985年 | 30篇 |
1984年 | 23篇 |
1983年 | 14篇 |
1982年 | 29篇 |
1981年 | 15篇 |
1980年 | 14篇 |
1979年 | 8篇 |
1978年 | 4篇 |
1977年 | 16篇 |
1976年 | 28篇 |
1975年 | 13篇 |
排序方式: 共有1487条查询结果,搜索用时 15 毫秒
51.
KH Neppelenbroek RS Seó VM Urban S Silva LN Dovigo JH Jorge NH Campanha 《Oral diseases》2014,20(4):329-344
In healthy individuals, Candida species are considered commensal yeasts of the oral cavity. However, these microorganisms can also act as opportunist pathogens, particularly the so‐called non‐albicans Candida species that are increasingly recognized as important agents of human infection. Several surveys have documented increased rates of C. glabrata, C. tropicalis, C. guilliermondii, C. dubliniensis, C. parapsilosis, and C. krusei in local and systemic fungal infections. Some of these species are resistant to antifungal agents. Consequently, rapid and correct identification of species can play an important role in the management of candidiasis. Conventional methods for identification of Candida species are based on morphological and physiological attributes. However, accurate identification of all isolates from clinical samples is often complex and time‐consuming. Hence, several manual and automated rapid commercial systems for identifying these organisms have been developed, some of which may have significant sensitivity issues. To overcome these limitations, newer molecular typing techniques have been developed that allow accurate and rapid identification of Candida species. This study reviewed the current state of identification methods for yeasts, particularly Candida species. 相似文献
52.
53.
Background
Whole body vibration (WBV) exposure at work is common and studies found evidence that this exposure might cause low back pain (LBP). A recent review concluded there is a lack of evidence of effective strategies to reduce WBV exposure. Most research in this field is focussed on the technical implications, although changing behaviour towards WBV exposure might be promising as well. Therefore, we developed an intervention programme to reduce WBV exposure in a population of drivers with the emphasis on a change in behaviour of driver and employer. The hypothesis is that an effective reduction in WBV exposure, in time, will lead to a reduction in LBP as WBV exposure is a proxy for an increased risk of LBP. 相似文献54.
Remifentanil-sevoflurane anaesthesia for laparoscopic cholecystectomy: comparison of three dose regimens 总被引:4,自引:0,他引:4
van Delden PG Houweling PL Bencini AF Ephraim EP Frietman RC van Niekerk J van Stolk MA Verheijen R Wajer OJ Mulder PG 《Anaesthesia》2002,57(3):212-217
The objective of this study was to determine a dosing regimen for remifentanil-sevoflurane anaesthesia that achieves an optimal balance between quality of anaesthesia and time to recovery. Patients undergoing elective laparoscopic cholecystectomy were randomly allocated to receive 0.4, 0.8 or 1.2 MAC (minimal alveolar concentration) of sevoflurane combined with remifentanil as required to maintain stable anaesthesia. For induction of anaesthesia, the remifentanil dose was 25 microg x kg(-1) x h(-1) and the mean propofol dose which was required to obtain loss of consciousness was 1.59 mg x kg(-1). During the maintenance phase, the mean remifentanil dose was 16.0, 14.1 and 13.0 microg x kg(-1) x h(-1) for the 0.4, 0.8 and 1.2 MAC groups, respectively. The mean sevoflurane maintenance dose was 0.91, 1.24 and 2.1% end-tidal for the 0.4, 0.8 and 1.2 MAC groups, respectively. The incidence of somatic responses was significantly higher in the 0.4 MAC sevoflurane group. Recovery times were significantly faster in the 0.4 compared to the 0.8 and 1.2 MAC groups and in the 0.8 compared to the 1.2 MAC group. The combination of 14 microg x kg(-1) x h(-1) remifentanil and 1.24% end-tidal sevoflurane achieved the optimal balance between the quality, and recovery from anaesthesia. 相似文献
55.
Human papillomavirus 16 load in normal and abnormal cervical scrapes: an indicator of CIN II/III and viral clearance 总被引:12,自引:0,他引:12
van Duin M Snijders PJ Schrijnemakers HF Voorhorst FJ Rozendaal L Nobbenhuis MA van den Brule AJ Verheijen RH Helmerhorst TJ Meijer CJ 《International journal of cancer. Journal international du cancer》2002,98(4):590-595
The relation between human papillomavirus type 16 (HPV 16) viral load in cervical scrapes and development of high-grade cervical intraepithelial neoplasia (CIN II or III) was studied in a nested case-control study of women with normal cytology (group A) and in a cohort of women with abnormal cytology (group B). HPV 16 DNA load was determined using a quantitative real-time PCR assay. In group A, case women (women with CIN II/III, n = 12) had a significantly higher viral load than control women (women with CIN < or = I, n = 47). This resulted in an increased relative risk of women with the 50% highest viral load for development of CIN II/III (OR 7.7; CI 1.6-33). In group B, women with CIN II/III (n = 38) had a significantly higher viral load than women with CIN < or = I (n = 25). Women with the 50% highest viral load had an increased relative risk of CIN II/III (OR 3.2; CI 1.1-9.3) and a decreased chance of both viral clearance and cytologic regression. Our data suggest that in women with normal cytology an increased HPV 16 load confers an increased risk of developing a CIN lesion. A sustained high viral load is subsequently informative for progression to a high-grade CIN lesion. 相似文献
56.
JH CHUNG 《中国药理学与毒理学杂志》2006,20(3)
Arsenic in drinking water is a worldwide health problem that is associated with cardiovascular disease, but the cause is currently unknown. In order to examine whether arsenic affects vasomotor tone in blood vessels, we investigated the effect of arsenic on agonist-induced vasorelaxation and vasoconstriction using the isolated rat aortic rings in in vitro organ bath system. 相似文献
57.
Diagnosis and management of cystic duct leakage after laparoscopic cholecystectomy, report of 3 cases 总被引:1,自引:0,他引:1
Li JH Liu HT 《第二军医大学学报》2005,26(10):1143-1143
BACKGROUND: Operative complications after laparoscopic cholecystectomy (LC) vary. Abdominal pain and other symptoms caused by fluid accumulation in the operative area are not uncommon. Cystic duct (CD) leakage is one of the main sources of the fluid. This study was to evaluate the procedures used in the diagnosis and management of CD leakage after LC. METHOD: The clinical materials of 3 patients with CD leakage after LC were studied retrospectively. 相似文献
58.
59.
Expression and immunogenicity of oncofetal antigen-immature laminin receptor in human renal cell carcinoma 总被引:3,自引:0,他引:3
Zelle-Rieser C Barsoum AL Sallusto F Ramoner R Rohrer JW Höltl L Bartsch G Coggin JH JR Thurnher M 《The Journal of urology》2001,165(5):1705-1709
PURPOSE: The 32 to 44 kDa. oncofetal antigen-immature laminin receptor (OFA-iLR) is a multifunctional protein expressed by various tumors, including breast, lung, ovary and prostate carcinoma as well as lymphoma. OFA-iLR has been implicated in tumor invasiveness, metastasis and growth. Interferon-gamma producing effector T cells and interleukin (IL)-10 producing suppressor T cells specific for OFA-iLR have been described. MATERIALS AND METHODS: The 43515 IgG2a anti-OFA-iLR monoclonal antibody was used to detect OFA-iLR expression in human renal cell carcinoma tissue by flow cytometry and immunoblotting. Spontaneous or therapy induced immune responses against OFA-iLR were determined in patients with metastatic renal cell carcinoma. Proliferative and cytokine (interferon-gamma and IL-10) responses of peripheral blood mononuclear cells from patients with renal cell carcinoma against recombinant OFA-iLR were assessed. RESULTS: Using flow cytometry OFA-iLR was detected in all 13 tumors tested. Immunoblotting revealed differences in OFA-iLR expression in renal cell carcinoma and normal kidney tissue. OFA-iLR specific proliferative and cytokine responses of mononuclear cells were detected in all 6 patients tested. Importantly evidence was also obtained that treating metastatic renal cell carcinoma with tumor lysate pulsed dendritic cells would enhance OFA-iLR specific immunity. CONCLUSIONS: This study demonstrates that OFA-iLR is an immunogenic tumor associated antigen in human renal cell carcinoma. OFA-iLR specific effector T cells producing interferon-gamma may have a role in the control of tumor growth, whereas suppressor T cells producing IL-10 may promote tumor tolerance and, thus, tumor progression. 相似文献
60.
Jaap Huisman Eline J Aukema Jan Berend Deijen Silvia CCM van Coeverden Gertjan JL Kaspers Heleen JH van der Pal Henriette A Delemarre-van de Waal 《BMC pediatrics》2008,8(1):25