全文获取类型
收费全文 | 1836篇 |
免费 | 140篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 102篇 |
妇产科学 | 29篇 |
基础医学 | 221篇 |
口腔科学 | 38篇 |
临床医学 | 209篇 |
内科学 | 453篇 |
皮肤病学 | 26篇 |
神经病学 | 88篇 |
特种医学 | 267篇 |
外科学 | 165篇 |
综合类 | 82篇 |
预防医学 | 118篇 |
眼科学 | 25篇 |
药学 | 79篇 |
中国医学 | 9篇 |
肿瘤学 | 62篇 |
出版年
2023年 | 9篇 |
2022年 | 13篇 |
2021年 | 16篇 |
2020年 | 21篇 |
2019年 | 24篇 |
2018年 | 35篇 |
2017年 | 24篇 |
2016年 | 18篇 |
2015年 | 32篇 |
2014年 | 68篇 |
2013年 | 93篇 |
2012年 | 79篇 |
2011年 | 74篇 |
2010年 | 61篇 |
2009年 | 88篇 |
2008年 | 65篇 |
2007年 | 90篇 |
2006年 | 56篇 |
2005年 | 55篇 |
2004年 | 48篇 |
2003年 | 48篇 |
2002年 | 51篇 |
2001年 | 43篇 |
2000年 | 53篇 |
1999年 | 42篇 |
1998年 | 90篇 |
1997年 | 59篇 |
1996年 | 70篇 |
1995年 | 48篇 |
1994年 | 50篇 |
1993年 | 49篇 |
1992年 | 21篇 |
1991年 | 16篇 |
1990年 | 17篇 |
1989年 | 46篇 |
1988年 | 34篇 |
1987年 | 27篇 |
1986年 | 22篇 |
1985年 | 20篇 |
1984年 | 23篇 |
1983年 | 17篇 |
1982年 | 16篇 |
1981年 | 22篇 |
1980年 | 15篇 |
1979年 | 11篇 |
1978年 | 16篇 |
1977年 | 23篇 |
1976年 | 8篇 |
1975年 | 14篇 |
1972年 | 9篇 |
排序方式: 共有1986条查询结果,搜索用时 0 毫秒
81.
Meera Shah Jennie H. Law Francesco Micheletto Matheni Sathananthan Chiara Dalla Man Claudio Cobelli Robert A. Rizza Michael Camilleri Alan R. Zinsmeister Adrian Vella 《Diabetes》2014,63(2):483-493
The contribution of elevated glucagon-like peptide 1 (GLP-1) to postprandial glucose metabolism after Roux-en-Y gastric bypass (RYGB) has been the subject of uncertainty. We used exendin-9,39, a competitive antagonist of GLP-1, to examine glucose metabolism, islet hormone secretion, and gastrointestinal transit in subjects after RYGB and in matched control subjects. Subjects were studied in the presence or absence of exendin-9,39 infused at 300 pmol/kg/min. Exendin-9,39 resulted in an increase in integrated postprandial glucose concentrations post-RYGB (3.6 ± 0.5 vs. 2.0 ± 0.4 mol/6 h, P = 0.001). Exendin-9,39 decreased insulin concentrations (12.3 ± 2.2 vs. 18.1 ± 3.1 nmol/6 h, P = 0.002) and the β-cell response to glucose (ϕTotal, 13 ± 1 vs. 11 ± 1 × 10−9 min−1,
P = 0.01) but did not alter the disposition index (DI). In control subjects, exendin-9,39 also increased glucose (2.2 ± 0.4 vs. 1.7 ± 0.3 mol/6 h, P = 0.03) without accompanying changes in insulin concentrations, resulting in an impaired DI. Post-RYGB, acceleration of stomach emptying during the first 30 min by exendin-9,39 did not alter meal appearance, and similarly, suppression of glucose production and stimulation of glucose disappearance were unaltered in RYGB subjects. These data indicate that endogenous GLP-1 has effects on glucose metabolism and on gastrointestinal motility years after RYGB. However, it remains uncertain whether this explains all of the changes after RYGB. 相似文献
82.
Animal models have demonstrated that CD36 facilitates cell membrane free fatty acid (FFA) transport, but its role in human metabolism is not well understood. We measured heart, liver, adipose (three depots), and muscle (truncal postural and thigh locomotive) FFA uptake using [11C]palmitate positron emission tomography (PET) scans in a family of five carrying the Pro90Ser CD36 mutation (2 homozygotes had no CD36) and matched control volunteers. PET scans were done under conditions of suppressed and slightly increased palmitate concentrations. During suppressed palmitate conditions, muscle and adipose palmitate uptake were markedly reduced in homozygotes but not heterozygotes for the Pro90Ser CD36 mutation, whereas when palmitate concentration was slightly increased, uptake in muscle and adipose did not differ between control subjects and homozygous family members. Hepatic FFA uptake was similar in all participants regardless of palmitate concentrations, whereas myocardial FFA uptake was diminished in the Pro90Ser homozygotes during both suppressed and increased palmitate conditions. We conclude that CD36 1) facilitates FFA transport into muscle and adipose tissue in humans when extracellular concentrations are reduced but not when they are modestly elevated, 2) is not rate limiting for hepatic FFA uptake, and 3) is needed for normal cardiac FFA uptake over a range of FFA concentrations from low to slightly elevated. 相似文献
83.
Claudio Cobelli Chiara Dalla Man Gianna Toffolo Rita Basu Adrian Vella Robert Rizza 《Diabetes》2014,63(4):1203-1213
The simultaneous assessment of insulin action, secretion, and hepatic extraction is key to understanding postprandial glucose metabolism in nondiabetic and diabetic humans. We review the oral minimal method (i.e., models that allow the estimation of insulin sensitivity, β-cell responsivity, and hepatic insulin extraction from a mixed-meal or an oral glucose tolerance test). Both of these oral tests are more physiologic and simpler to administer than those based on an intravenous test (e.g., a glucose clamp or an intravenous glucose tolerance test). The focus of this review is on indices provided by physiological-based models and their validation against the glucose clamp technique. We discuss first the oral minimal model method rationale, data, and protocols. Then we present the three minimal models and the indices they provide. The disposition index paradigm, a widely used β-cell function metric, is revisited in the context of individual versus population modeling. Adding a glucose tracer to the oral dose significantly enhances the assessment of insulin action by segregating insulin sensitivity into its glucose disposal and hepatic components. The oral minimal model method, by quantitatively portraying the complex relationships between the major players of glucose metabolism, is able to provide novel insights regarding the regulation of postprandial metabolism. 相似文献
84.
Vella Michael A. Dumas Ryan P. Chreiman Kristen Wasser Thomas Smith Brian P. Reilly Patrick M. Seamon Mark J. Shiroff Adam 《Journal of thrombosis and thrombolysis》2020,49(3):420-425
Journal of Thrombosis and Thrombolysis - Little is known about the association between epidural catheters (EC) and venous thromboembolism (VTE) in trauma. We sought to study this association and... 相似文献
85.
Ian R Grubb Sarah W Beckham Michel Kazatchkine Ruth M Thomas Eliot R Albers Mauro Cabral Joep Lange Stefano Vella Manoj Kurian Chris Beyrer for the IAS Treatment for Key Affected Populations Working Group 《Journal of the International AIDS Society》2014,17(1)
Introduction
Scientific research has demonstrated the clinical benefits of earlier initiation of antiretroviral treatment (ART), and that ART can markedly reduce HIV transmission to sexual partners. Ensuring universal access to ART for those who need it has long been a core principle of the HIV response, and extending the benefits of ART to key populations is critical to increasing the impact of ART and the overall effectiveness of the HIV response. However, this can only be achieved through coordinated efforts to address political, social, legal and economic barriers that key populations face in accessing HIV services.Discussion
Recent analyses show that HIV prevalence levels among key populations are far higher than among the general population, and they experience a range of biological and behavioural factors, and social, legal and economic barriers that increase their vulnerability to HIV and have resulted in alarmingly low ART coverage. World Health Organization 2014 consolidated guidance on HIV among key populations offers the potential for increased access to ART by key populations, following the same principles as for the general adult population. However, it should not be assumed that key populations will achieve greater access to ART unless stigma, discrimination and punitive laws, policies and practices that limit access to ART and other HIV interventions in many countries are addressed.Conclusions
Rights-based approaches and investments in critical enablers, such as supportive legal and policy environments, are essential to enable wider access to ART and other HIV interventions for key populations. The primary objective of ART should always be to treat the person living with HIV; prevention is an important, additional benefit. ART should be provided only with informed consent. The preventive benefits of treatment must not be used as a pretext for failure to provide other necessary HIV programming for key populations, including comprehensive harm reduction and other prevention interventions tailored to meet the needs of key populations. An end to AIDS is only possible if we overcome the barriers of criminalization, stigma and discrimination that remain key drivers of the HIV epidemics among key populations. 相似文献86.
87.
Giulia Ghirardo Elisa Benetti Francesca Poli Enrico Vidal Manuela Della Vella Emanuele Cozzi Luisa Murer 《Pediatric transplantation》2014,18(1):E1-E5
Even if kidney graft survival has improved during the last decades, sensitized pediatric patients are an emerging problem. We describe a 17‐yr‐old male who lost his first graft due to chronic rejection becoming hyperimmunized (CDC PRA 99.61%). A desensitization protocol based on high‐dose IVIG, PP, and two Mabthera® infusions was performed with minor response (CDC PRA post‐desensitization 80%). One month after his second non‐living transplant, he developed a biopsy‐proven AMR; post‐transplant immunological monitoring showed the presence of donor‐specific anti‐DQ5 antibodies (DSA, MFI 20.000). He received methylprednisolone pulses and 45 PP sessions without clinical response; eculizumab was then used to salvage a kidney undergoing severe PP‐resistant rejection. A biopsy performed after the fourth eculizumab infusion showed complete resolution of AMR. Eculizumab infusions were then continued for the first year post‐transplantation. Two yr after transplantation, graft function is stable. Anti‐C5 therapy may represent an effective therapeutic option in pediatric patients with PP‐resistant AMR. 相似文献
88.
89.
90.
目的探讨经关节入路微创钢板固定(MIPPO)技术治疗股骨远端C型骨折的临床疗效。方法2002年4月~2005年2月,应用MIPPO技术治疗股骨远端C型骨折14例,按AO/ASIF分类:C1型3例,C2型6例,C3型5例。先行关节内骨折切开复位、松质骨螺钉固定,再行髁上部分骨折间接复位、经关节内切口插入髁支撑钢板或LISS钢板桥接固定骨折。结果12例患者获得10~32个月(平均18.4个月)随访,骨折均获愈合,愈合时间10周~12个月,平均4.6个月。按Kolmert和Wulff的评价标准:优4例,良5例,可2例,差1例,优良率为75%。结论应用MIPPO技术治疗股骨远端C型骨折实现了微创操作,具有创伤小、软组织干扰少、骨折愈合快等优点,疗效满意。 相似文献