全文获取类型
收费全文 | 1113篇 |
免费 | 70篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 26篇 |
妇产科学 | 24篇 |
基础医学 | 118篇 |
口腔科学 | 13篇 |
临床医学 | 150篇 |
内科学 | 279篇 |
皮肤病学 | 43篇 |
神经病学 | 32篇 |
特种医学 | 200篇 |
外科学 | 90篇 |
综合类 | 18篇 |
预防医学 | 54篇 |
眼科学 | 9篇 |
药学 | 63篇 |
中国医学 | 2篇 |
肿瘤学 | 58篇 |
出版年
2023年 | 7篇 |
2022年 | 15篇 |
2021年 | 19篇 |
2020年 | 13篇 |
2019年 | 18篇 |
2018年 | 19篇 |
2017年 | 25篇 |
2016年 | 16篇 |
2015年 | 18篇 |
2014年 | 20篇 |
2013年 | 48篇 |
2012年 | 35篇 |
2011年 | 51篇 |
2010年 | 27篇 |
2009年 | 33篇 |
2008年 | 36篇 |
2007年 | 32篇 |
2006年 | 52篇 |
2005年 | 35篇 |
2004年 | 42篇 |
2003年 | 32篇 |
2002年 | 39篇 |
2001年 | 35篇 |
2000年 | 27篇 |
1999年 | 30篇 |
1998年 | 20篇 |
1997年 | 34篇 |
1996年 | 30篇 |
1995年 | 19篇 |
1994年 | 27篇 |
1993年 | 14篇 |
1992年 | 18篇 |
1991年 | 26篇 |
1990年 | 22篇 |
1989年 | 28篇 |
1988年 | 23篇 |
1987年 | 20篇 |
1986年 | 26篇 |
1985年 | 20篇 |
1984年 | 17篇 |
1983年 | 7篇 |
1982年 | 14篇 |
1980年 | 8篇 |
1979年 | 7篇 |
1978年 | 8篇 |
1977年 | 9篇 |
1975年 | 8篇 |
1971年 | 12篇 |
1970年 | 6篇 |
1966年 | 6篇 |
排序方式: 共有1192条查询结果,搜索用时 15 毫秒
101.
102.
H. K. DÜRR CHRISTIANE BODE R. KRUPINSKI J. CH. BODE 《European journal of clinical investigation》1978,8(3):189-191
Macroamylasaemia was produced in vitro by incubation of hydroxyethylstarch with serum, and in vivo by intravenous infusion of hydroxyethylstarch. Gel filtration on Sephadex G-100 revealed distinct differences in molecular size distribution between such hydroxyethylstarch-induced macroamylase and the usual form of naturally occurring macroamylase which was observed in a few patients from our hospital. Further studies demonstrated that the gel filtration elution pattern of amylase activity in serum containing hydroxyethylstarch-induced macroamylase is significantly altered with time in vitro and in vivo, probably because of an enzymatic degradation of the hydroxyethylstarch components of the macromolecular complexes. In a healthy volunteer the serum amylase activity was elevated to a maximum of 797 u/l and the renal clearance rate of amylase was diminished to a minimum of 0.3 ml/min after infusion of 500 ml of a 6% solution of hydroxyethylstarch, as compared to 300 u/l, and 0.95 ml/min, respectively, during the pre-infusion period. 相似文献
103.
Familial hemiplegic migraine: a clinical comparison of families linked and unlinked to chromosome 19 总被引:5,自引:0,他引:5
GM Terwindt RA Ophoff J Haan RR Frants MD Ferrari for the DMGRG 《Cephalalgia : an international journal of headache》1996,16(3):153-155
We compared the clinical characteristics of 50 patients from three unrelated families with familial hemiplegic migraine (FHM) linked to chromosome 19, with those of 20 patients from two families with FHM not linked to chromosome 19. We found no significant differences for age at onset, frequency and duration of attacks, duration of the paresis, and occurrence of basilar migraine symptoms. In the linked families, significantly more patients reported unconsciousness during attacks (39%, vs 15%; p<0.05) and provocation of attacks by mild head trauma (70% vs 40%; p< 0.05). In one linked family patients also displayed chronic progressive cerebellar ataxia, whereas in one unlinked family benign infantile convulsions occurred in addition to FHM. Interestingly, so far an association with cerebellar ataxia was only described in chromosome 19-linked families. FHM linked to chromosome 19 and FHM unlinked to chromosome 19 do not differ with respect to clinical features. 相似文献
104.
We conducted an open observational study with blinded endpoint evaluation to validate the use of the Duke treadmill score in identifying patients likely to require coronary intervention. We studied 101 consecutive patients referred for coronary angiography from a cardiology clinic. All patients had a Bruce protocol exercise test. A 70% stenosis was regarded as significant. Patients were referred for percutaneous transluminal coronary angioplasty (PTCA) or coronary artery bypass grafting (CABG) surgery, if indicated. The Duke score was calculated as follows: exercise time (min) - (5 x ST segment deviation [mm]) - (4 x angina index [text]). Patients were classified into low, medium and high risk. The patients at high risk are more likely to have a significant stenosis (53/58 vs 30/43: p = 0.01 [OR 4.59 95% CI 1.34-16.6]) and require CABG or PTCA (47/58 vs 16/43: p < 0.001 [OR 7.21 95% CI 2.69-19.8]) than those at medium/low risk. Multiple logistic regression analysis, including ST segment depression, exercise time and symptoms shows that the score independently predicts a significant stenosis (p = 0.002) and the need for coronary intervention (p = 0.001). Introducing the score can help to identify those patients who need priority investigation. 相似文献
105.
106.
Red cell loss following orthopedic surgery: the case against postoperative blood salvage 总被引:3,自引:0,他引:3
J Umlas ; RR Foster ; SA Dalal ; SM O'Leary ; L Garcia ; MS Kruskall 《Transfusion》1994,34(5):402-406
BACKGROUND: Expensive devices have been developed for the collection and transfusion of blood salvaged after hip or knee arthroplasty. STUDY DESIGN AND METHODS: The volume of salvaged red cells was measured for the first 6 hours after operation. This volume was compared to total red cell loss during hospitalization and to the volume of allogeneic red cells transfused. RESULTS: Mean postoperative red cell loss in 31 patients following hip replacement was 55 +/− 29 mL and that in 20 patients following knee replacement was 121 +/− 50 mL. The 6-hour wound drainage represented 8.7 and 16.8 percent of overall red cell loss during hospitalization for hip and knee replacement, respectively. The transfusion of postoperatively salvaged red cells would have supplanted transfusion of less than one-third of a unit of allogenic blood after hip replacement and two-thirds of a unit after knee replacement. Only three patients (5.9%) lost red cell volume in the drainage equivalent to or in excess of 1 unit of red cells (180 mL). The volume of red cells salvaged postoperatively bore no relationship to perioperative red cell losses as a whole. CONCLUSION: The relatively small red cell loss in the postoperative period in most arthroplasty patients does not appear to justify the routine use of this technique for the recovery of autologous blood. 相似文献
107.
BACKGROUND: The primary aim of the study was to estimate the incidence of Crohn's disease (CD) and ulcerative colitis (UC), collectively known as inflammatory bowel disease (IBD), in Malta in a well-defined population during a 13-year study period. METHODS: Diagnostic criteria for CD and UC were defined. A diagnosis of IBD was obtained from the histopathology reports at St. Luke's Hospital, Malta, between January 1993 and December 2005. The date of diagnosis was defined as the date of the first histopathology report revealing signs of IBD. RESULTS: Incidence rates were standardized using the direct method on the European Standard Population. The mean incidence of UC in males was 8.16 per 100,000 per year and for females was 7.59 per 100,000 per year, while that for CD in males was 0.96 per 100,000 per year and for females 1.622 per 100,000 per year. Using linear regression, in UC there is an almost significant (P = 0.069) increasing trend with time but no difference by gender (P = 0.591). On the other hand, in CD there is no significant trend with time (P = 0.555) but almost a significant difference by gender (P = 0.078). CONCLUSIONS: This is the first Maltese study in which the incidence of IBD has been recorded. In Malta the incidence of UC is similar to the overall incidence of other European countries while the incidence of CD is lower. In fact, the incidence rates of CD are among the lowest in Europe, similar to other southern European countries. 相似文献
108.
Changes in blood center red blood cell distributions in the era of patient blood management: the trends for collection (TFC) study 下载免费PDF全文
109.
Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions. 总被引:11,自引:3,他引:11 下载免费PDF全文
C Hession L Osborn D Goff G Chi-Rosso C Vassallo M Pasek C Pittack R Tizard S Goelz K McCarthy et al. 《Proceedings of the National Academy of Sciences of the United States of America》1990,87(5):1673-1677
A cDNA for endothelial leukocyte adhesion molecule 1 (ELAM-1) was isolated by transient expression in COS-7 cells of a subtracted cDNA library from cytokine-treated human umbilical vein endothelial cells (HUVECs), with selection of ELAM-1-expressing clones by adhesion of transfected cells to the human promyelocytic cell line HL-60. This cloning method requires neither antibody nor purified ligand. ELAM-1-expressing COS cells bind the promyelocytic cell line HL-60 by a Ca2(+)-dependent but temperature-independent mechanism. Although ELAM-1 is homologous to mammalian lectins, its interaction with HL-60 cells is not inhibited by simple carbohydrate structures. ELAM-1-expressing COS cells also bind human neutrophils and the human colon carcinoma cell line HT-29, but not the B-cell line Ramos. However, Ramos cells adhere to cytokine-treated HUVECs but not control HUVECs, confirming the existence of other inducible adhesion molecules. In addition, the binding of HL-60 cells or neutrophils to ELAM-1-expressing COS cells is not inhibited by a monoclonal antibody (60.3) directed to an inhibitory epitope on CD18, indicating that the ELAM-1 ligand, although uncharacterized, is not a member of the CD11/CD18 family. 相似文献
110.
Barbara Zanini Francesco Lanzarotto Alessandra Mora Stefania Bertolazzi Daniele Turini Bruno Cesana Francesco Donato Chiara Ricci Fulvio Lonati Francesco Vassallo Carmelo Scarcella Alberto Lanzini 《Digestive and liver disease》2010,42(12):865-870