全文获取类型
收费全文 | 64960篇 |
免费 | 4569篇 |
国内免费 | 294篇 |
专业分类
耳鼻咽喉 | 826篇 |
儿科学 | 1792篇 |
妇产科学 | 1599篇 |
基础医学 | 10608篇 |
口腔科学 | 1701篇 |
临床医学 | 6180篇 |
内科学 | 13113篇 |
皮肤病学 | 996篇 |
神经病学 | 5993篇 |
特种医学 | 2959篇 |
外国民族医学 | 45篇 |
外科学 | 8260篇 |
综合类 | 557篇 |
一般理论 | 83篇 |
预防医学 | 5016篇 |
眼科学 | 1218篇 |
药学 | 4710篇 |
1篇 | |
中国医学 | 162篇 |
肿瘤学 | 4004篇 |
出版年
2022年 | 476篇 |
2021年 | 1061篇 |
2020年 | 694篇 |
2019年 | 928篇 |
2018年 | 1138篇 |
2017年 | 789篇 |
2016年 | 930篇 |
2015年 | 1114篇 |
2014年 | 1363篇 |
2013年 | 2356篇 |
2012年 | 3008篇 |
2011年 | 3109篇 |
2010年 | 2258篇 |
2009年 | 1910篇 |
2008年 | 2824篇 |
2007年 | 3052篇 |
2006年 | 2956篇 |
2005年 | 2804篇 |
2004年 | 2841篇 |
2003年 | 2583篇 |
2002年 | 2670篇 |
2001年 | 2185篇 |
2000年 | 2226篇 |
1999年 | 2007篇 |
1998年 | 959篇 |
1997年 | 809篇 |
1996年 | 718篇 |
1995年 | 731篇 |
1994年 | 597篇 |
1993年 | 655篇 |
1992年 | 1461篇 |
1991年 | 1414篇 |
1990年 | 1350篇 |
1989年 | 1371篇 |
1988年 | 1135篇 |
1987年 | 1134篇 |
1986年 | 1074篇 |
1985年 | 983篇 |
1984年 | 712篇 |
1983年 | 660篇 |
1982年 | 485篇 |
1981年 | 454篇 |
1980年 | 392篇 |
1979年 | 631篇 |
1978年 | 378篇 |
1977年 | 374篇 |
1975年 | 386篇 |
1974年 | 414篇 |
1973年 | 349篇 |
1972年 | 340篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
Gijbels F Sanderink G Wyatt J Van Dam J Nowak B Jacobs R 《British dental journal》2004,197(3):149-52; discussion 140
AIM: The aim of this study was to measure organ doses and calculate the effective dose for indirect and direct digital cephalometric exposures. MATERIAL AND METHODS: Indirect digital cephalometric exposures were made of a Rando phantom head using a Cranex Tome multipurpose unit with storage phosphor plates from Agfa and the direct digital (Charge Coupled Device, CCD) exposures were made with a Proline Ceph CM unit. Exposure settings were 70 kV and 4 mAs for indirect digital exposures. Direct digital exposures were made with 70 kV, 10 mA and a total scanning time of 23 s. TLD700 dosemeters were used to measure organ doses, and the effective doses were calculated with (effective dose(sal)) and without inclusion of the salivary glands. A pilot study was carried out to compare diagnostic image quality of both imaging modalities. RESULTS: Effective doses were 1.7 microSv for direct digital and 1.6 microSv for indirect digital cephalometric imaging. When salivary glands were included in the calculation, effective doses(sal) were 3.4 microSv and 2.2 microSv respectively. Organ doses were higher for direct digital imaging, except for the thyroid gland, where the organ doses were comparable. Diagnostic image quality of indirect and direct digital cephalometric images seemed comparable. CONCLUSION: Effective dose and effective dose(sal) were higher for direct digital cephalometric exposure compared with indirect digital exposure. Organ doses were higher for direct digital cephalography. From preliminary data, it may be presumed that diagnostic image quality of indirect and direct digital cephalometric images are comparable. 相似文献
52.
BACKGROUND: A randomized clinical trial was performed to test the efficacy of a fluoridated hydrogen peroxide-based mouthrinse on gingivitis and tooth whitening in a two-phase study. The first phase (28 days) included the experimental gingivitis phase; the second phase (5 months) was the oral hygiene phase, which included rinsing. METHODS: A total of 99 subjects were included in the study and were randomly assigned to receive either placebo or test mouthrinse. Clinical measures were chosen to reflect the gingival health and tooth whiteness in an intent-to-treat study design. Statistical analyses of clinical parameters related to gingival health and tooth color were conducted, using the method of generalized estimating equations (GEE), with an exchangeable working correlation to accommodate tooth-level data. Baseline differences between the groups were adjusted. Microbial samples taken at the beginning and at the end of the study were analyzed by DNA-DNA hybridization technique, to determine whether there was any adverse shift in supragingival flora. RESULTS: Eastman bleeding index, modified gingival index, intensity of stain, and extent of stain were significantly reduced in the test group at 6 months compared to baseline (P < 0.05). In contrast, only the Eastman bleeding index was significantly reduced in the control group (P < 0.05). The reduction in the index of gingival inflammation for the test group was significantly greater than for the control group (P = 0.004). Subjects using the test rinse were also six times more likely to exhibit an improvement in tooth color after 6 months than were subjects using placebo (P = 0.002). As a result of the clinical evaluations and microbial analysis, test mouthrinse was found to be safe during a 6-month period. CONCLUSION: The results of this study indicate that the fluoridated hydrogen peroxide-based mouthrinse effectively whitens teeth and significantly reduces gingivitis. 相似文献
53.
Glucosyltransferases from Streptococcus mutans are thought to play an important role in bacterial adherence to the tooth surface. The goal of the present study was to determine the effect of the deletion of the gtfC gene, which encodes a glucosyltransferase that catalyses primarily the formation of insoluble glucan (mutan), on colonization of S. mutans in a mixed-species biofilm model of supragingival plaque. A gtfC deletion mutant of S. mutans UA159 grew poorly in biofilms on a polystyrene surface in Todd–Hewitt medium containing sucrose, but biofilm formation in the semi-defined fluid universal medium (FUM) was not affected. The S. mutans gtfC mutant colonized with the same efficiency as the wild-type strain when grown together with five other species in a mixed-species biofilm on hydroxyapatite in a mixture of FUM and saliva with pulses of sucrose and showed the same ability to demineralize enamel in vitro . Colonization of mutant and wild-type strains was also equal in an association experiment in specific-pathogen-free rats. However, the gtfC mutant gave rise to more dentinal fissure lesions and smooth surface caries than the wild-type strain; this could be caused by a change in diffusion properties as a result of to the lack of mutan. 相似文献
54.
The complex, pennate architecture of the human masseter muscle points to a functional division into more than the commonly distinguished deep and superficial parts. In this study, the possible existence of regional differences in activation was examined. EMG activity was registered in three deep and three superficial regions with the use of bipolar fine-wire electrodes. Recordings were made during different static bite tasks, in specified directions, and with a specified bite-force magnitude. A linear bite-force/EMG relationship was observed. Furthermore, it appeared that muscle regions showed a different pattern of change in activity as a function of bite-force direction. Heterogeneity was nearly absent in anteriorly-, anteriomedially-, and medially-directed bites, but became increasingly obvious in the other bite-force directions. The posterior deep region showed the most aberrant activation pattern, which was almost opposite that from the other regions. This part was fully active in posterolaterally-directed bites. The posterior superficial region showed the largest variability in activity as a function of bite-force direction. The results point to a functional partition of the masseter muscle in at least three parts: anterior deep, posterior deep, and superficial. A further subdivision of the superficial portion might be present, but was not as obvious as the division of the deep masseter. 相似文献
55.
Van Landuyt KL Yoshida Y Hirata I Snauwaert J De Munck J Okazaki M Suzuki K Lambrechts P Van Meerbeek B 《Journal of dental research》2008,87(8):757-761
Functional monomers in adhesive systems can improve bonding by enhancing wetting and demineralization, and by chemical bonding to calcium. This study tested the hypothesis that small changes in the chemical structure of functional monomers may improve their bonding effectiveness. Three experimental phosphonate monomers (HAEPA, EAEPA, and MAEPA), with slightly different chemical structures, and 10-MDP (control) were evaluated. Adhesive performance was determined in terms of microtensile bond strength of 4 cements that differed only for the functional monomer. Based on the Adhesion-Decalcification concept, the chemical bonding potential was assessed by atomic absorption spectrophotometry of the dissolution rate of the calcium salt of the functional monomers. High bond strength of the adhesive cement corresponded to low dissolution rate of the calcium salt of the respective functional monomer. The latter is according to the Adhesion-Decalcification concept, suggestive of a high chemical bonding capacity. We conclude that the adhesive performance of an adhesive material depends on the chemical structure of the functional monomer. 相似文献
56.
Haywood VB Cordero R Wright K Gendreau L Rupp R Kotler M Littlejohn S Fabyanski J Smith S 《The Journal of clinical dentistry》2005,16(1):17-22
OBJECTIVE: This research systematically evaluated the use of a clinically proven desensitizing dentifrice prior to a bleaching regimen in a randomized, multi-center, parallel group, open label clinical study following Good Clinical Practice guidelines. METHODOLOGY: Fourteen dental offices in West Palm Beach, Florida participated in the study during April/May 2004. Fourteen days prior to bleaching, impressions and oral soft tissue assessments were performed, and patients were randomized to either a KNO3 plus fluoride dentifrice (Sensodyne Fresh Mint), or a standard fluoride dentifrice (Crest Regular), brushing 2x per day. On Day 14, patients returned to the dental office for their custom tray and the dispensation of a bleaching kit (Day White Excel 3; 9.5% hydrogen peroxide and KNO3). This was used daily according to the manufacturer's instructions for 30 minutes, and normal oral hygiene continued to be performed using the assigned toothbrush and dentifrice, brushing 2x per day. At the end of each bleaching day, patients answered diary questions about the occurrence and intensity of sensitivity. At the conclusion of the 14-day bleaching period (Day 28), patients returned to their dental office for re-examination, returning all products and diaries. Within seven days of completing the study, patients answered a telephone patient satisfaction survey. RESULTS: A total of 202 patients in fourteen (14) dental offices completed all aspects of the study and were used for the analysis. The professionally dispensed bleaching product provided an improvement of approximately 4.4 Vita shades, regardless of whether it was used with the KNO3 plus fluoride (Sensodyne) or a standard fluoride (Crest) dentifrice. The patient perception of increased sensitivity caused by the bleaching treatment was low but measurable. In the first week of the bleaching, significantly more patients using the KNO3 plus fluoride dentifrice were free from sensitivity (58%) than the standard fluoride dentifrice group (42%). During the 14-day bleaching treatment period, the KNO3 dentifrice patients experienced significantly more "sensitivity free days" (average = 10.1) compared to the standard fluoride dentifrice group (average = 8.6). CONCLUSION: The use of the KNO3 plus fluoride dentifrice (Sensodyne), two weeks prior to and throughout bleaching, may be a useful adjunct for the management of sensitivity caused by professionally dispensed bleaching products. With the bleaching-induced tooth sensitivity, those patients in the KNO3 plus fluoride toothpaste group were significantly more satisfied with their whitening experience and willing to repeat the bleaching treatment. 相似文献
57.
Swallowing thresholds of mandibular implant-retained overdentures with variable portion sizes 总被引:1,自引:0,他引:1
Fontijn-Tekamp FA Slagter AP Van der Bilt A Van't Hof MA Kalk W Jansen JA 《Clinical oral implants research》2004,15(3):375-380
We analysed the effect of three portion sizes Optocal Plus (small, medium and large) on swallowing thresholds in subjects with either conventional complete dentures or mandibular implant-retained overdentures (transmandibular and permucosal cylindric implants). Tests were carried out in 52 women and 15 men (mean age 59 years) 4 years after treatment in a randomised controlled clinical trial. The results indicated that the degree of mucosal support for the mandibular denture did not affect the number of chewing strokes, time till swallowing or swallowed particle size. Only the chewing rate differed: subjects wearing mandibular implant-retained overdentures chewed the food at a higher rate than complete-denture wearers. With larger portion sizes, subjects needed significantly more chewing strokes and time until swallowing and they would have swallowed larger particles. Men chewed their food more efficiently than women, as they used the same number of chewing strokes and time, but achieved a greater particle size reduction at the swallowing moment. 相似文献
58.
The aim of the present study was to determine the relationship between the flow rate of saliva and characteristics of the food. Therefore, we determined the rate of saliva secretion in 16 healthy subjects in rest and while chewing natural and artificial foods (toast with and without margarine, three sizes of breakfast cake, and Parafilm). We also determined the chewing rate, number of chewing cycles until swallowing, and time until swallowing. The physical characteristics of the foods were quantified from force-deformation experiments. The results showed that the average at which mechanical failure occurred (yield force) was 1.86 ± 0.24 N for the breakfast cake and 16.3 ± 1.3 N for the melba toast. The flow rates obtained without stimulation and with Parafilm were significantly lower (P < 0.001) than the flow rates obtained from chewing food. No differences in flow rate occurred between the natural foods. The flow rates of the saliva as obtained without stimulation, with Parafilm stimulation, and with chewing on the various foods were significantly correlated (P < 0.05). There were no significant differences in chewing rate among the foods. The number of chewing cycles and the time until swallowing significantly depended on the type or volume of the food. 相似文献
59.
B Van den Bossche G Floridor J Deconinck P Van Den Winkel A Hubin 《Journal of electroanalytical chemistry (Lausanne, Switzerland)》2002,531(1):61-70
A numerical simulation and optimization tool for pulsed current electroplating processes is applied to the industrial preparation of high quality Tl-203 deposits. Reliable predictions on current efficiency and deposit quality are enabled by the construction of an adequate reaction mechanism for Tl deposition from highly basic solutions (pH >12.5) in the presence of the EDTA complexing agent. In order to account for multi-ion mass transfer effects near the electrode, the diluted electrochemical ionic system model is to be solved without simplifications, in combination with electron transfer and homogeneous complex forming reactions as defined by the proposed reaction mechanism. Physical and chemical parameters for this model are achieved by comparing and tuning simulated steady-state polarization and efficiency curves at a rotating disc electrode (RDE) with experimental data. 相似文献
60.
Pucher JJ Lamendola-Sitenga K Ferguson D Van Swoll R 《The Journal of the Western Society of Periodontology/Periodontal abstracts》1999,47(4):101-107
This investigation was undertaken to determine if an ionic toothbrush was effective at removing plaque and reducing gingivitis in patients wearing orthodontic appliances. Fifty-two orthodontic patients were randomly assigned to one of two groups and completed a six-week double-blind study. Group 1 consisted of the test group using the ionic toothbrush with an active battery; group 2 consisted of the control group using the ionic toothbrush with an inactive battery. The plaque and gingival indices were measured at baseline, two weeks, and six weeks. The findings demonstrated that the active ionic toothbrush was no more effective at plaque removal and gingivitis reduction than the inactive toothbrush. Although the active toothbrush did effectively remove plaque and reduce gingivitis over the course of six weeks, it showed no significant improvement over the same toothbrush that contained an inactive battery. It was observed that the ionic toothbrush effectively reduced plaque and gingivitis regardless of the presence or absence of an active battery. The clinical findings demonstrated that an active ionic toothbrush was no more effective in removing plaque and reducing gingivitis in patients with orthodontic appliances than an inactive ionic toothbrush. 相似文献