Mosquitoes of the mangrove forests of India: part six--Kundapur, Karnataka and Kannur, Kerala

Mosquitoes of 26 species belonging to 16 subgenera and 11 genera were recorded in the Kundapur mangroves of Karnataka, and 17 species belonging to 11 subgenera and 7 genera were recorded in the mangroves of Kannur, Kerala along the west coast of India. Genera recorded were Aedes, Anopheles, Armigeres, Culex, Heizmannia, Lutzia, Mansonia, Ochlerotatus, Tripteroides, Uranotaenia, and Verrallina. Species common to both mangrove forests were Ae. albopictus, Ae. vittatus, An. jamesi, Ar. subalbatus, Cx. gelidus, Cx. infantulus, Cx. pseudovishnui, Cx. sitiens, Cx. tritaeniorhynchus, Oc. wardi, Ur. atra, and Ve. luguhris. Tree holes and swamp pools were the common larval habitats, with more species occurring in tree holes in Kundapur than in Kannur. Adults of Ae. albopictus, Ae. vittatus, Ar. aureolineatus, Ar. subalbatus, Cx. bitaeniorhynchus, Cx. sitiens, Ma. uniformis, and Ve. lugubris bloodfed on humans.     

Left atrial myxoma presenting as acute inferior wall infarction-a case report

Acute myocardial infarction is a rare form of presentation in patients with left atrial myxoma. With wider availability of echocardiography, more and more patients with atrial myxomas will be diagnosed. This report describes a patient with left atrial myxoma who presented features of acute myocardial infarction and had surgical removal of LA myxoma.     

Transurethral external sphincterotomy sans external sphincter

Of 51 patients with detrusor-sphincter dyssynergia undergoing external urethral spincterotomy by transurethral resection, histological examination revealed no skeletal muscle in the resected tissue in six patients. The functional improvement which resulted in these cases despite this finding with an explanation for the same forms the topic of this paper.     

Influence of 1-dodecylazacycloheptan-2-one (Azone) on the topical therapy of cutaneous herpes simplex virus type 1 infection in hairless mice with 2',3'-di-O-acetyl-9-beta-D-arabinofuranosyladenine and 5'-O-valeryl-9-beta-D-arabinofuranosyladenine

The predictive value of a recently developed physical model was tested in the topical treatment of cutaneous infections caused by herpes simplex virus type 1 in hairless mice with two ester prodrugs of 9-beta-D-arabinofuranosyladenine (ara-A) (1). The tests were conducted with 2',3'-di-O-acetyl-ara-A (4) and 5'-O-valeryl-ara-A (3) topically applied with and without 15% 1-dodecylazacycloheptan-2-one (2) (Azone), a percutaneous penetration enhancer. In addition to the in vivo studies, in vitro diffusion cell experiments with excised, full-thickness skin from hairless mice were conducted to determine the penetration enhancement effects of 2. As previously observed, 2 was able to induce remarkably large (100- to 1000-fold) flux enhancements in these in vitro experiments. Consistent with predictions based on the physical model studies, formulations of 3 and 4 without 2 had little or no influence on the pathogenesis of the herpes simplex virus type 1 infections; when 2 was present in the formulations, both 3 and 4 had dramatic therapeutic effects consistent with the predictions made with the physical model. Prodrug 4 with 2 was especially efficacious in the prevention of virus-induced lesions and in the survival of all animals. Similar results were obtained with acyclovir plus 2 in this model system.     

Clarifying domains of internalizing psychopathology using neurophysiology

Current initiatives such as the National Institute of Mental Health's Research Domain Criteria project aim to reorganize classification of mental disorders along neurobiological lines. Here, we describe how consideration of findings from psychiatric research employing two physiological measures with distinct neural substrates--the startle blink reflex and the error-related negativity (ERN)--can help to clarify relations among disorders entailing salient anxiety or depressive symptomatology. Specifically, findings across various studies and reviews reveal distinct patterns of association for both the startle blink reflex and the ERN with three key domains of psychopathology: (1) Fear (or phobic) disorders (distinguished by increased startle to unpleasant stimuli, but normal-range ERN). (2) Non-phobic anxiety disorders and negative affect (associated with increased ERN, increased startle across all types of emotional stimuli and increased baseline startle) and, more tentatively (3) Major depression (for which patterns of response for both startle and ERN appear to vary, as a function of severity and distinct symptomatology). Findings from this review point to distinct neurobiological indicators of key psychopathology domains that have been previously demarcated using personality and diagnostic data. Notably, these indicators exhibit more specificity in their relations with these three domains than has been seen in quantitative-dimensional models. Implications of these findings are discussed.     

The shear bond strength of acetone and ethanol-based bonding agents to bleached teeth

PURPOSE: The purpose of this in vitro study was to evaluate the: (1) shear bond strength (SBS) of acetone and ethanol-based bonding agents to composite resin 24 hours after being bleached with 35% hydrogen peroxide; and (2) interface morphology and mode of fracture (IMMF) between composite resin and enamel. METHODS: Forty extracted teeth were randomly assigned into 4 groups: (1) group 1: 35% H2O2 + acetone; (2) group 2: H2O2 + ethanol; (3) group 3: acetone; (4) group 4: ethanol. All teeth were acid etched, bonding agents were applied, and a composite resin stub was bonded and stored again in saline for 24 hours. SBS was determined, and scanning electron microscopy (SEM) was used for IMMF evaluation. RESULTS: SBS was significantly lower in bleached than unbleached teeth (P < .001), but SBS did not differ between the acetone-based or ethanol-based adhesives (P = .55) and bleaching did not interact with adhesive treatment (P = .39). IMMF analysis of the unbleached teeth showed a continuous interface between the resin and enamel. By contrast, bleached teeth showed sparse contact between the resin and enamel and the resin was poorly infiltrated into the enamel surface. CONCLUSION: Morphologic changes in human tooth enamel, 24 hours after bleaching, were associated with a reduction in the shear bond strength of adhesives.