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101.
Boultwood J; Fidler C; Lewis S; MacCarthy A; Sheridan H; Kelly S; Oscier D; Buckle VJ; Wainscoat JS 《Blood》1993,82(9):2611-2616
Acquired interstitial deletions of the long arm of chromosome 5 occur frequently in the myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Recently IRF1, a putative tumor suppressor gene localized to the long arm of chromosome 5, has been shown to be deleted from the 5q- chromosome in a group of patients with MDS and AML. It has been suggested that the loss of IRF1 may be critical to the development of the 5q- syndrome. We have investigated the allelic loss of IRF1 in a group of 12 patients with MDS and a 5q deletion and 2 patients with AML and a 5q deletion. Gene dosage experiments demonstrated that 12 of 14 patients had loss of one allele of the IRF1 gene but no evidence of homozygous loss and that 2 patients with 5q- syndrome retained both copies of the gene. The retention of IRF1 on the 5q- chromosome in these two cases has been confirmed by fluorescent in situ hybridization localization using an IRF1 cosmid. Pulsed field gel electrophoresis was used to determine whether there was any evidence for structural rearrangement in the region encompassing the IRF1 gene in these two patients. No aberrant bands were detected with a range of rare cutter enzyme digests. We conclude that IRF1 maps outside the commonly deleted segment of the 5q- chromosome and that loss of IRF1 is not solely responsible for the development of the 5q- syndrome. 相似文献
102.
Fibrinogen binding to human blood platelets: effect of gamma chain carboxyterminal structure and length 总被引:4,自引:0,他引:4
Recent evidence suggests that fibrinogen binding to platelets is mediated by the 12 carboxyterminal amino acid residues of the gamma chain. Because human plasma fibrinogen gamma chains differ in mol wt and carboxyterminal amino acid sequence, we examined the effect of such gamma chain heterogeneity on platelet-fibrinogen interactions, using two fibrinogens of distinct composition, separated by ion exchange chromatography. One fibrinogen possessed only gamma chains of mol wt 50,000 (F gamma 50), the predominant gamma chain species found in plasma. The other fibrinogen possessed equal amounts of gamma chains with mol wt 50,000 and 57,500 (F gamma 50,57.5), with the longer gamma chain (gamma 57.5) possessing an amino acid extension at the carboxyterminal end. The latter fibrinogen was 50% less effective than F gamma 50 in supporting ADP-induced platelet aggregation at concentrations of .01 to 2 mg/mL. Scatchard analysis revealed no difference in the binding affinities of the two fibrinogens to ADP- treated platelets, but the amount of F gamma 50,57.5 that was bound to platelets at saturation was only 50% that of F gamma 50. Fibrinogen receptors that remained unoccupied in the presence of saturating concentrations of F gamma 50,57.5, however, could be occupied by fresh F gamma 50. Excess unlabeled F gamma 50 displaced both radiolabeled fibrinogens from activated platelets, and both fibrinogens bound to the same platelet receptor, as judged by the inhibition of binding to stimulated platelets by a monoclonal antibody directed against the glycoprotein (GP) IIb/IIIa complex. Furthermore, an intact GPIIb/IIIa complex was required for these reactions, since platelets incubated with EDTA at 37 degrees C at alkaline pH failed to aggregate and bound neither fibrinogen in response to ADP following recalcification. Approximately 50% of each fibrinogen bound irreversibly to platelets after one hour and failed to dissociate in the presence of 10 mmol/L of EDTA or excess unlabeled F gamma 50. The data demonstrate that heterodimeric F gamma 50,57.5 binds less well to platelets and supports platelet aggregation only half as well as homodimeric F gamma 50. These results support prior conclusions that the carboxyterminal portion of the gamma chain is important in platelet-fibrinogen interactions, and suggest that the 20 amino acid, hydrophobic gamma chain carboxyterminal extension of F gamma 50,57.5 may sterically hinder the interaction of this fibrinogen with platelet receptors. 相似文献
103.
Focal pulmonary abnormalities: evaluation with F-18 fluorodeoxyglucose PET scanning 总被引:31,自引:0,他引:31
Patz EF Jr; Lowe VJ; Hoffman JM; Paine SS; Burrowes P; Coleman RE; Goodman PC 《Radiology》1993,188(2):487
104.
105.
Pathogenesis of ductal plate malformation 总被引:4,自引:0,他引:4
VJ DESMET 《Journal of gastroenterology and hepatology》2004,19(S7):S356-S360
106.
107.
One hundred and six patients with angina pectoris who underwent routine coronary angiography and left ventriculography were given intracoronary injection of thallium 201. The myocardial images had excellent resolution because of lack of interference from the background activity. The myocardial images and the left ventriculograms showed 94% correlation. Correlation between scans and EKG was lower. There was no correlation between the degree of coronary artery stenosis and 201Tl scan. Currently, the intracoronary injection of 201Tl at rest does not yield additional information to coronary angiography and left ventriculography. 相似文献
108.
Caroli disease: high-frequency US and pathologic findings 总被引:5,自引:0,他引:5
Marchal GJ; Desmet VJ; Proesmans WC; Moerman PL; Van Roost WW; Van Holsbeeck MT; Baert AL 《Radiology》1986,158(2):507-511
Three infants with nonobstructive bile duct dilatation (Caroli disease) are described. The bile duct pathology was associated with autosomal recessive polycystic kidney disease in two patients and with severe destruction of the renal parenchyma of unknown origin in the other. Sonograms of the liver showed, besides bile duct dilatations, intraluminal bulbar protrusions, bridge formation across dilated lumina, and portal radicles partially or completely surrounded by dilated bile ducts. Liver biopsy was performed in two patients, and in one patient, the biopsy sample confirmed the findings noted on sonograms. These findings support the hypothesis that the normal embryogenesis of intrahepatic bile ducts is arrested in the pathogenesis of this disease. 相似文献
109.
VJ Parker AJ Douglas 《American journal of reproductive immunology (New York, N.Y. : 1989)》2008,60(1):89-89
Problem: Stress in early pregnancy has been linked to increased abortion rates. Immune stress in early pregnancy inhibits progesterone secretion in mice. As prolactin both mediates implantation and drives progesterone secretion, we hypothesised that stress would decrease prolactin secretion in early pregnancy.
Material and Methods: Lipopolysaccharide (LPS; 12.5μg intraperitoneally) as an immune stress or vehicle were administered to day 5.5 early pregnant and virgin c57/Bl6J mice. They were killed by decapitation 60, 120 or 240 min later and trunk blood was collected and analysed for prolactin concentration (ELISA); corticosterone was also analysed (RIA).
Results: LPS significantly decreased prolactin concentration in early pregnancy (P<0.001, 2-way ANOVA); however, there was no significant difference in the virgin groups. In contrast, LPS significantly elevated corticosterone concentration in all groups (P<0.001, 2-way ANOVA), confirming activation of the hypothalamo-pituitary-adrenal stress axis.
Conclusions: Stress decreased prolactin secretion during early pregnancy, and might explain stress-disrupted implantation and progesterone secretion. 相似文献
Material and Methods: Lipopolysaccharide (LPS; 12.5μg intraperitoneally) as an immune stress or vehicle were administered to day 5.5 early pregnant and virgin c57/Bl6J mice. They were killed by decapitation 60, 120 or 240 min later and trunk blood was collected and analysed for prolactin concentration (ELISA); corticosterone was also analysed (RIA).
Results: LPS significantly decreased prolactin concentration in early pregnancy (P<0.001, 2-way ANOVA); however, there was no significant difference in the virgin groups. In contrast, LPS significantly elevated corticosterone concentration in all groups (P<0.001, 2-way ANOVA), confirming activation of the hypothalamo-pituitary-adrenal stress axis.
Conclusions: Stress decreased prolactin secretion during early pregnancy, and might explain stress-disrupted implantation and progesterone secretion. 相似文献
110.