Oral submucous fibrosis as a precancerous condition

Abstract – An evaluation of the malignant potential of submucous fibrosis, based on observations of 89 patients with the disease in Ernakulam District, Kerala, India was done. Out of the 89 patients, 12 were referred patients and 77 were diagnosed in population based studies. At the time of first examination oral cancer was found to be coexistent in nine (10%) cases. For 66 patients follow-up observations ranging from 4 to 15 yr (median 8 yr) were available. During this period malignant transformation was observed in three patients (4.5%). Considering malignant transformation and coexistence together, oral cancer was observed in 13% of the present material. Leukoplakia was found in 26% of the patients with submucous fibrosis. Out of 42 submucous fibrosis patients biopsied, 12% showed squamous cell carcinoma, 26% epithelial dysplasia, and 76% atrophic epithelium. These findings reinforced the hypothesis that submucous fibrosis is a precancerous condition.     

Effect of Administration of a Single Dose of Testosterone Oenanthate on Human Serum and Seminal Plasma Inhibin Concentration

Der Einfluß einer Einzeldosis von Testosteron-Oenanthat auf die Inhibin-Konzentration im menschlichen Serum und im menschlichen Spermaplasma
Bei vier erwachsenen Freiwilligen wurde der Einfluß einer Einzeldosis von 250 mg Testosteron-Oenanthat i.m. auf die Serum- und Spermaplasmawerte von Inhibin untersucht. Dabei konnte ein signifikanter Abfall von Serum-FSH und -LH am 6. Tage festgestellt werden, während die Testosteronwerte hoch waren. Dieses Ergebnis war gefolgt von einem scharfen Anstieg der Serum- und Spermaplasma-Konzentration für Inhibin am 8. bzw. 12. Tag. Darüber hinaus legen die Ergebnisse nach Ansicht der Autoren den Schluß nahe, daß eine positive Beziehung zwischen der Serum- und Spermaplasma-Konzentration für Inhibin besteht.     

Histopathological Changes Following Laser Ablation of a Left-Sided Accessory Pathway in a Human

Laser ablation was performed intraoperatively in a patient with coronary artery disease and Wolff-Parkinson-White syndrome. Histopathological evaluation of the laser ablation site revealed a transverse laser incision in the left atrial septum and mitral valve annulus. There was hemorrhage in the atrioventricular (AV) groove with interruption of a posterolateral AV connection. The laser lesion was confined largely to the atrial aspect of the AV annulus. We conclude that laser catheter ablation of accessory pathways is feasible in humans.