Efficacy of Botulinum Therapy in Correcting the Level of Pain Syndrome and Quality of Life in Patients with Cervical Dystonia

Neuroscience and Behavioral Physiology - Objectives. To assess the severity of pain syndrome, emotional status, and quantitative levels of humoral serotonin in patients with cervical dystonia (CD)...     

Association of Chronotype,Road Traffic Accidents,and Polymorphisms in Genes Linked with the Biological Clock and the Dopaminergic System

Neuroscience and Behavioral Physiology - Objective. To study the association between single-nucleotide polymorphisms (SNP) of the RORA (rs1159814), CLOCK (rs12649507), PER3 (rs2640909), NPSR1...     

Efficacy of Music Therapy in the Rehabilitation of Stroke Patients

Neuroscience and Behavioral Physiology - Objective. To assess the dynamics of recovery of motor, speech, and autonomous functions in patients with ischemic stroke (IS) using music therapy....     

Use of Anchoring Motifs to Support the Central and Peripheral Locations of Opsins in Optogenetics

Neuroscience and Behavioral Physiology - One version of the optogenetic prosthetization of the degenerative retina is an approach based on creation of an ON/OFF receptive field for ganglion neurons...     

An Immunohistochemical Study of the Pathways of the Influence of Dopamine on Orexinergic Neurons in the Perifornical Area of the Hypothalamus

Neuroscience and Behavioral Physiology - Confocal microscopy was used to analyze double immunolabeling and provided evidence of the locations of a large number of tyrosine...     

Learning with Reinforcement: the Role of Immediate Feedback and the Internal Model of the Situation

Neuroscience and Behavioral Physiology - Human behavior in conditions of partial indeterminacy of the outcome is characterized by correspondence between the frequency of actions and the probability...     

Comparative Characteristics of the Expression of Inducible NO Synthase in the Hippocampus of Humans and Experimental Animals

Neuroscience and Behavioral Physiology - Objective: To study the characteristics of the expression of inducible NO synthase (iNOS) in hippocampal fields CA1 and CA3 in adult male humans and adult...     

Vanillylmandelic acid protects against reperfusion injury in an experimental animal model of myocardial infarction

Vanillylmandelic acid, a catecholamine end-metabolite, has been shown to have several biological properties in previous studies, despite considered biologically inactive. We examined the potential effects of vanillylmandelic acid on the ischemic heart following myocardial infarction and reperfusion on a rat model. Thirty-four female Wistar rats were randomized into two groups, control and experimental. They were anesthetized and subjected to myocardial infarction through left anterior descending artery ligation. A previously studied dose of vanillylmandelic acid (10 mg/kg) was administered and the following parameters were studied during ischemia and reperfusion: a) mortality b) severity of ventricular tachyarrhythmias c) premature ventricular contractions and d) heart rate. Administration of vanillymandelic acid significantly reduced the severity of ventricular tachyarrhythmias and mortality rate during reperfusion, while it did not affect any other of the parameters studied. In conclusion, reperfusion injury was blunted through vanillylmandelic acid administration, which seems to be mediated by parasympathetic activation.     

Bio‐Inspired Multiple Cycle Healing and Damage Sensing in Elastomer–Magnet Nanocomposites

Damage‐sensing and healing are biological functions which are urgently required in structural health monitoring and remediation of engineering structures. The development of a bio‐inspired multiple cycle damage sensing and triggered healing magnet–polymer nanocomposite (Magpol) is reported. Magpol is comprised of an acrylonitrile butadiene co‐polymer (NBR) matrix and a magnetic nanoparticle (MNP) filler. Magpol nanocomposites in a range of MNP filler concentrations are studied. NBR is selected as the matrix due to its extensive use in industrial coatings, for example, in the automotive industry. Mn‐Zn ferrite MNP is chosen due to its appropriate Curie temperature and good specific absorption rate. Exposure of damaged Magpol to a remote external alternating magnetic field results in MNP heating. The MNP heats the surrounding NBR matrix, resulting in triggered healing. Fractured Magpol samples are successfully healed over several cycles. Incorporation of rhodamine b mechano‐chromophore in Magpol results in multicycle damage sensing by photo‐luminescent absorption. Thus, the developed Magpol is attractive for structural health monitoring and remediation application.