全文获取类型
收费全文 | 3575668篇 |
免费 | 284880篇 |
国内免费 | 13967篇 |
专业分类
耳鼻咽喉 | 49142篇 |
儿科学 | 115021篇 |
妇产科学 | 91714篇 |
基础医学 | 567824篇 |
口腔科学 | 95505篇 |
临床医学 | 325583篇 |
内科学 | 626643篇 |
皮肤病学 | 95342篇 |
神经病学 | 299203篇 |
特种医学 | 140712篇 |
外国民族医学 | 379篇 |
外科学 | 552724篇 |
综合类 | 106047篇 |
现状与发展 | 23篇 |
一般理论 | 2334篇 |
预防医学 | 301639篇 |
眼科学 | 82666篇 |
药学 | 243962篇 |
23篇 | |
中国医学 | 10028篇 |
肿瘤学 | 168001篇 |
出版年
2021年 | 55244篇 |
2020年 | 35200篇 |
2019年 | 58213篇 |
2018年 | 72086篇 |
2017年 | 55011篇 |
2016年 | 60555篇 |
2015年 | 74418篇 |
2014年 | 108611篇 |
2013年 | 173982篇 |
2012年 | 96097篇 |
2011年 | 98464篇 |
2010年 | 118995篇 |
2009年 | 122009篇 |
2008年 | 84592篇 |
2007年 | 88901篇 |
2006年 | 98561篇 |
2005年 | 93875篇 |
2004年 | 95785篇 |
2003年 | 86671篇 |
2002年 | 76403篇 |
2001年 | 110688篇 |
2000年 | 103551篇 |
1999年 | 101999篇 |
1998年 | 66083篇 |
1997年 | 63413篇 |
1996年 | 61218篇 |
1995年 | 56678篇 |
1994年 | 50822篇 |
1993年 | 47344篇 |
1992年 | 72419篇 |
1991年 | 71032篇 |
1990年 | 68278篇 |
1989年 | 67320篇 |
1988年 | 62144篇 |
1987年 | 61514篇 |
1986年 | 57852篇 |
1985年 | 57967篇 |
1984年 | 51702篇 |
1983年 | 46898篇 |
1982年 | 42568篇 |
1981年 | 40172篇 |
1980年 | 37860篇 |
1979年 | 43583篇 |
1978年 | 37997篇 |
1977年 | 34123篇 |
1976年 | 31980篇 |
1975年 | 31708篇 |
1974年 | 33216篇 |
1973年 | 31952篇 |
1972年 | 29662篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
C.T. PEASE M. FENNELL R.C.D. STAUGHTON D.A. BREWERTON 《The British journal of dermatology》1987,117(2):161-167
Polymorphonuclear leukocyte (PMN) migration was assessed in vitro using the agarose plate method in patients with psoriasis vulgaris, and compared with an age- and sex-matched control group. No significant difference was found between the two groups in the PMN response to the chemotactic substances F-Met-Leu-Phe (FMLP) or zymosan activated serum (ZAS). Equally, the chemokinetic or chemotactic potential of psoriatic serum did not differ from control serum. Our results do not support a primary abnormality of PMN function in psoriasis. 相似文献
992.
R González-Amaro L Baranda C Abud-Mendoza J F Salazar-González B Moncada R Garcia J Alcocer-Varela 《International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association》1987,55(4):651-656
Lepromatous leprosy is characterized by immune anergy and abnormal suppressor T-cell function. Contrasuppressor cells are a subset of CD8+, vicia villosa-adherent T lymphocytes. T-contrasuppressor (Tcs) cells act on T-helper cells to cause them to become unresponsive to the action of T-suppressor cells. In 8 lepromatous (LL) and 7 tuberculoid (TT) patients, and 6 healthy contacts we studied the percent of the following lymphocyte subsets: CD3+, CD4+, CD8+, Ia+, vicia villosa+ (VV+), CD8, VV+, VV, Ia+, and Ia, Tac+. This was done in baseline status as well as post-stimulation with recombinant gamma interferon (rIFN-gamma). We found that peripheral blood mononuclear cells from LL and TT patients and controls exhibit a similar number of putative contrasuppressor lymphocytes (CD8, VV+ cells). However, in the contrasuppressor subset from LL patients we found a low percent of Ia+ (p less than 0.05 compared to controls or TT). In the three groups studied, the rIFN-gamma enhanced the percent of Ia+ lymphocytes in the CD8, VV+ cell subpopulation. However, the CD8, VV+ lymphocytes from LL patients, despite the effect of rIFN-gamma, continue to have a low percent of Ia+ cells (p less than 0.05 compared to controls or TT). These findings suggest that LL patients might have abnormalities in the contrasuppressor immune circuit. Future functional studies on the role of Tcs cells in the anergy seen in LL will be required in order to define the apparent dysfunction occurring in this disease. 相似文献
993.
994.
995.
996.
S B Wieslander B T Mortensen L Binderup N I Nissen 《European journal of haematology》1987,39(1):35-38
10 patients with CLL and 2 with CML were treated with gradually increasing doses of 1 alpha(OH)D3, up to 4 micrograms daily during 6 wk. 3 patients with preleukemia and 1 with myelofibrosis were treated with 2 micrograms daily of 1 alpha(OH)D3 for a prolonged period up to 17 wk. The treatment with 1 alpha (OH)D3 did not result in changes of disease parameters in any of the patients under study. Receptor studies for 1,25(OH)2D3 were performed in 8 CLL patients and revealed only 1 patient with increased specific receptor binding capacity. The maximum tolerable dose of 1 alpha(OH)D3 varied individually, but was in the range of 2-4 micrograms daily. 相似文献
997.
Studies were performed in hypercholesterolemic rabbits to determine whether the hydrophobic surfactant, Poloxalene 2930 (Pol), is of benefit under these conditions. Lipoprotein analyses plus chemical and morphologic studies of the aorta were performed to evaluate the results. In one study, rabbits were made hypercholesterolemic by dietary means and then divided into two groups and given a cholesterol-free diet with one group additionally given Pol with treatment continued for 10 weeks. Pol treatment resulted in less atherosclerosis but the mechanism for this effect was not apparent from lipoprotein analysis. In the other study 3 groups of rabbits were given a cholesterol-rich diet for 16 weeks. Two groups received Pol supplement with one of these groups receiving a dose that was too small to prevent hypercholesterolemia. In this group plus the group on diet alone comparable degrees of hypercholesterolemia were maintained throughout the study. Lipoprotein abnormalities were similar in these two groups except that those on Pol had a more normal cholesterol to apolipoprotein B ratio. The amount of atherosclerosis in both groups was mild but aortic cholesterol content was much less for the Pol group. It is concluded that Pol limits cholesterol accumulation in the aortic wall of hypercholesterolemic rabbits and can retard the development of atherosclerosis. 相似文献
998.
N Scopinaro E Gianetta D Friedman G F Adami E Traverso B Vitale M Castagnola G Semino M Summa V Bachi 《Gastroenterology Clinics of North America》1987,16(3):529-531
Biliopancreatic diversion is a very effective method for weight reduction. In some instances it is too effective and needs to be revised. 相似文献
999.
1000.