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41.
Allergic multimorbidity of asthma,rhinitis and eczema over 20 years in the German birth cohort MAS 下载免费PDF全文
Hannah Gough Linus Grabenhenrich Andreas Reich Nora Eckers Oliver Nitsche Dirk Schramm John Beschorner Ute Hoffmann Antje Schuster Carl‐Peter Bauer Johannes Forster Fred Zepp Young‐Ae Lee Renate L. Bergmann Karl E. Bergmann Ulrich Wahn Susanne Lau Thomas Keil MAS study group 《Pediatric allergy and immunology》2015,26(5):431-437
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Brendan K. Huang Ute A. Gamm Vineet Bhandari Mustafa K. Khokha Michael A. Choma 《Biomedical optics express》2015,6(9):3515-3538
Microscale quantification of cilia-driven fluid flow is an emerging area in medical physiology, including pulmonary and central nervous system physiology. Cilia-driven fluid flow is most completely described by a three-dimensional, three-component (3D3C) vector field. Here, we generate 3D3C velocimetry measurements by synthesizing higher dimensional data from lower dimensional measurements obtained using two separate optical coherence tomography (OCT)-based approaches: digital particle image velocimetry (DPIV) and dynamic light scattering (DLS)-OCT. Building on previous work, we first demonstrate directional DLS-OCT for 1D2C velocimetry measurements in the sub-1 mm/s regime (sub-2.5 inch/minute regime) of cilia-driven fluid flow in Xenopus epithelium, an important animal model of the ciliated respiratory tract. We then extend our analysis toward 3D3C measurements in Xenopus using both DLS-OCT and DPIV. We demonstrate the use of DPIV-based approaches towards flow imaging of Xenopus cerebrospinal fluid and mouse trachea, two other important ciliary systems. Both of these flows typically fall in the sub-100 μm/s regime (sub-0.25 inch/minute regime). Lastly, we develop a framework for optimizing the signal-to-noise ratio of 3D3C flow velocity measurements synthesized from 2D2C measures in non-orthogonal planes. In all, 3D3C OCT-based velocimetry has the potential to comprehensively characterize the flow performance of biological ciliated surfaces.OCIS codes: (110.4500) Optical coherence tomography, (120.7250) Velocimetry, (170.3340) Laser Doppler velocimetry, (170.6480) Spectroscopy, speckle 相似文献
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Michael J. Connor Jr Colleen Kraft Aneesh K. Mehta Jay B. Varkey G. Marshall Lyon Ian Crozier Ute Str?her Bruce S. Ribner Harold A. Franch 《Journal of the American Society of Nephrology : JASN》2015,26(1):31-37
AKI has been observed in cases of Ebola virus disease. We describe the protocol for the first known successful delivery of RRT with subsequent renal recovery in a patient with Ebola virus disease treated at Emory University Hospital, in Atlanta, Georgia. Providing RRT in Ebola virus disease is complex and requires meticulous attention to safety for the patient, healthcare workers, and the community. We specifically describe measures to decrease the risk of transmission of Ebola virus disease and report pilot data demonstrating no detectable Ebola virus genetic material in the spent RRT effluent waste. This article also proposes clinical practice guidelines for acute RRT in Ebola virus disease. 相似文献
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Thimm E Richter-Werkle R Kamp G Molke B Herebian D Klee D Mayatepek E Spiekerkoetter U 《Journal of inherited metabolic disease》2012,35(2):263-268
Objective
The implementation of NTBC into treatment of hypertyrosinemia type I (HT I) greatly improved survival by prevention of acute liver failure and hepatocellular carcinoma. However, there are first reports of cognitive impairment in patients with elevated plasma tyrosine concentrations. 相似文献49.
Hoffmann L Haussmann U Mueller M Spiekerkoetter U 《Journal of inherited metabolic disease》2012,35(2):269-277
Tandem mass spectrometry-based newborn screening correctly identifies individuals with very long-chain acyl-CoA dehydrogenase
deficiency (VLCADD). However, a great number of healthy individuals present with identical acylcarnitine profiles during catabolism
in the first three days of life. We routinely perform an enzyme activity assay as confirmation analysis in newborns identified
by screening. Whereas VLCAD residual activities of less than 10% are clearly diagnostic and indicate patients at risk of clinical
disease, the clinical relevance of higher residual activities is unclear. In this study we assess the molecular basis in 34
individuals with residual activities of 10-50%. We identify two pathogenic mutations in patients that result in residual activities
as high as 22%, while individuals with residual activities of 25-50% either present with a heterozygous or no mutation in
the VLCAD gene. In addition, confirmed heterozygous parents present with residual activities as low as 32%. 相似文献