全文获取类型
收费全文 | 561篇 |
免费 | 14篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 42篇 |
妇产科学 | 91篇 |
基础医学 | 40篇 |
口腔科学 | 3篇 |
临床医学 | 31篇 |
内科学 | 88篇 |
皮肤病学 | 13篇 |
神经病学 | 19篇 |
特种医学 | 23篇 |
外科学 | 121篇 |
综合类 | 11篇 |
预防医学 | 23篇 |
眼科学 | 8篇 |
药学 | 41篇 |
中国医学 | 3篇 |
肿瘤学 | 18篇 |
出版年
2023年 | 5篇 |
2022年 | 4篇 |
2021年 | 13篇 |
2020年 | 6篇 |
2019年 | 3篇 |
2018年 | 4篇 |
2017年 | 5篇 |
2016年 | 10篇 |
2015年 | 10篇 |
2014年 | 13篇 |
2013年 | 19篇 |
2012年 | 31篇 |
2011年 | 24篇 |
2010年 | 23篇 |
2009年 | 32篇 |
2008年 | 39篇 |
2007年 | 36篇 |
2006年 | 30篇 |
2005年 | 29篇 |
2004年 | 25篇 |
2003年 | 36篇 |
2002年 | 24篇 |
2001年 | 15篇 |
2000年 | 16篇 |
1999年 | 7篇 |
1998年 | 13篇 |
1997年 | 6篇 |
1996年 | 15篇 |
1995年 | 6篇 |
1994年 | 13篇 |
1993年 | 11篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 6篇 |
1987年 | 7篇 |
1986年 | 3篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 5篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1955年 | 1篇 |
排序方式: 共有577条查询结果,搜索用时 0 毫秒
71.
Ghazzawi IM; Sarraf MG; Taher MR; Khalifa FA 《Human reproduction (Oxford, England)》1998,13(2):348-352
A prospective study was carried out to compare the fertilizing capability
and pregnancy outcome following intracytoplasmic sperm injection (ICSI)
using spermatozoa obtained from ejaculates, or surgically from epididymis
or seminiferous tubules. A total of 77 ICSI cycles (one per patient) was
included. In all, 28 patients had severe oligoasthenoteratozoospermia, 19
patients had obstructive azoospermia and 30 patients had non-obstructive
azoospermia. The main outcome measures were fertilization rate per injected
metaphase II oocyte and the clinical pregnancy rate per embryo transferred
back to the female recipients. In patients with severe
oligoasthenoteratozoospermia, the fertilization and pregnancy rates were 79
and 25 %. In patients with obstructive azoospermia, for whom epididymal
spermatozoa were used, these were 75 and 28%, and in the non-obstructive
group for which testicular spermatozoa were used for injection, they were
69 and 21% respectively. These rates were not significantly different in
the three groups (P = 0.85 and P = 0.14 respectively), suggesting that
spermatozoa from the ejaculates and epididymal or testicular biopsies are
able to fertilize equally by using ICSI. Live birth per embryo transfer was
significantly reduced in patients with non-obstructive azoospermia compared
to the other two groups. The high abortion rate (50%) in the group in which
testicular spermatozoa were used raises doubts about the developmental
competence of such embryos.
相似文献
72.
The clinical history and histological features of seven cases of granulomatous mastitis are presented. The lesion occurs in young parous women as a tender extra-areolar breast lump. Histologically, non-caseating discrete granulomas are present, confined to breast lobules with, in three cases, coalescence of the granulomas and microabscess formation. Pathogenesis of the changes is discussed. It is thought that granulomatous mastitis is an entity morphologically distinct from duct ectasia/plasma cell mastitis and the commoner forms of granulomatous breast diseases. 相似文献
73.
Splenomegaly, pancytopenia and pregnancy: a case report and review of the literature 总被引:1,自引:0,他引:1
We present a 35-year-old previously healthy primigravida who presented at 264/7 weeks of gestation with pancytopenia and hepatosplenomegaly. She received 10 transfusions and delivered at 344/7 weeks of gestation by cesarean section. Two months later following splenectomy, she was diagnosed with malaria. Physicians should have a high index of suspicion for malaria in the context of splenomegaly and pancytopenia in pregnancy even in the absence of fever. 相似文献
74.
75.
76.
77.
78.
Synchronous endometrial and cervical tumors in a 26-year-old nullipara: diagnostic modalities updated 总被引:1,自引:0,他引:1
Hascalik S Celik O Erdem G Usta U Alkan A Karakas HM Mizrak B 《Gynecologic and obstetric investigation》2005,60(3):171-176
Proton magnetic resonance spectroscopy (MRS), performed on conventional magnetic resonance imaging (MRI) scanners, provides useful information at the biochemical level. MRS has been used to measure tissue concentrations of proton-containing compounds such as organic and amino acids, and sugars in living tissues. We have used MRS in a 26-year-old female with suspected cervical and endometrial carcinomas. With the use of the above mentioned technique, biochemical differences in the endometrium and the cervix tissues were detected. The presented case is the first virgin patient in the relevant literature in whom endometrial and cervical carcinoma was detected. Choline (Cho), creatine (Cr), N-acetylaspartate (NAA), lipid and lactate region of the MRS spectrum suggested that the technique could be used as an indicator of metabolic alterations in the cervical and endometrial tumor cells. 相似文献
79.
Wortelboer HM Usta M van Zanden JJ van Bladeren PJ Rietjens IM Cnubben NH 《Biochemical pharmacology》2005,69(12):1879-1890
To study the possible interplay between glutathione metabolism of and MRP inhibition by thiol reactive compounds, the interactions of a series of alpha,beta-unsaturated carbonyl compounds with multidrug resistance proteins 1 and 2 (MRP1/ABCC1 and MRP2/ABCC2) were studied. Alpha,beta-unsaturated carbonyl compounds react with glutathione, and therefore either their parent compound or their intracellularly formed glutathione metabolite(s) can modulate MRP-activity. Inhibition was studied in Madin-Darby canine kidney cells stably expressing MRP1 or MRP2, and isolated Sf9-MRP1 or Sf9-MRP2 membrane vesicles. In the latter model system metabolism is not an issue. Of the series tested, three distinct groups could be discriminated based on differences in interplay of glutathione metabolism with MRP1 inhibition. Curcumin inhibited MRP1 transport only in the vesicle model pointing at inhibition by the parent compound. The glutathione conjugates of curcumin also inhibit MRP1 mediated transport, but to a much lesser extent than the parent compound curcumin. In the cellular model system, it was demonstrated that glutathione conjugation of curcumin leads to inactivation of its inhibitory potential. Demethoxycurcumin and bisdemethoxycurcumin inhibited MRP1 in both the vesicle and cellular model pointing at inhibitory potency of at least the parent compound and possibly their metabolites. A second group, including caffeic acid phenethyl ester inhibited MRP1-mediated calcein transport only in the MDCKII-MRP1 cells, and not in the vesicle model indicating that metabolism appeared a prerequisite to generate the active inhibitor. Finally cinnamaldehyde, crotonaldehyde, trans-2-hexanal, citral, and acrolein did not inhibit MRP1. For MRP2, inhibition was much less in both model systems, with the three curcuminoids being the most effective. The results of this study show the importance to study the complex interplay between MRP-inhibitors and their cellular metabolism, the latter affecting the ultimate potential of a compound for cellular MRP-inhibition. 相似文献
80.
Introduction: The influence of using a roller mixer just after blood collection on the ratio of rejected samples in coagulation tests was investigated retrospectively. Methods: Numbers of blood samples collected in centralized units of outpatient clinics for prothrombin time (PT) were 24 050 in group I and 24 500 in group II (H. Aral, unpublished data). In group I, the tubes were inverted manually. In group II, the tubes were left standing on roller mixer with 30 rpm. The ratios of rejected samples of the two groups were compared statistically with ki‐square analysis. Results: Using a roller mixer, rate of rejection decreased from 0.79% (group I) to 0.20% (group II) (P < 0.001). Conclusion: We suggested using roller mixer to improve the reliability of coagulation testing. Such standardization in preanalytical phase may be helpful in preventing laboratory errors and obtaining correct test results in coagulation tests. 相似文献