HyunKyung Lee  Sora Oh  Chang Eun Song  Hang Ken Lee  Sang Kyu Lee  Won Suk Shin  Won-Wook So  Sang-Jin Moon  Jong-Cheol Lee 《RSC advances》2019,9(36):20733

A non-fullerene small molecule acceptor, SF-HR composed of 3D-shaped spirobifluorene and hexyl rhodanine, was synthesized for use in bulk heterojunction organic solar cells (OSCs). It possesses harmonious molecular aggregation between the donor and acceptor, due to the interesting diagonal molecular shape of SF-HR. Furthermore, the energy level of SF-HR matches well with that of the donor polymer, poly(3-hexyl thiophene) (P3HT) in this system which can affect efficient charge transfer and transport properties. As a result, OSCs made from a P3HT:SF-HR photoactive layer exhibited a power conversion efficiency rate of 4.01% with a high V_OC of 1.00 V, a J_SC value of 8.23 mA cm⁻², and a FF value of 49%. Moreover, the P3HT:SF-HR film showed superior thermal and photo-stability to P3HT:PC₇₁BM. These results indicate that SF-HR is specialized as a non-fullerene acceptor for use in high-performance OSCs.

A 3D-shaped SF-HR was designed and synthesized for use in non-fullerene organic solar cells. Owing to the aligned energy levels, the P3HT:SF-HR system exhibited a high efficiency of 4.01% with good thermal stability and photostability.  相似文献   

    

Lavinia Neubert  Paul Borchert  Hoen‐Oh Shin  Friedemann Linz  Willi L Wagner  Gregor Warnecke  Florian Laenger  Axel Haverich  Helge Stark  Marius M Hoeper  Mark Kuehnel  Maximilian Ackermann  Danny Jonigk 《The Journal of Pathology: Clinical Research》2019,5(2):108-114

Pulmonary veno‐occlusive disease (PVOD) is a rare lung disease characterized by fibrotic narrowing of pulmonary veins leading to pulmonary hypertension (PH) and finally to death by right heart failure. PVOD is often accompanied by pulmonary capillary hemangiomatosis (PCH), a marked abnormal proliferation of pulmonary capillaries. Both morphological patterns often occur together and are thought to be distinct manifestations of the same disease process and accordingly are classified together in group 1′ of the Nice classification of PH. The underlying mechanisms of these aberrant remodeling processes remain poorly understood. In this study, we investigated the three‐dimensional structure of these vascular lesions in the lung explant of a patient diagnosed with PVOD by μ‐computed tomography, microvascular corrosion casting, electron microscopy, immunohistochemistry, correlative light microscopy and gene expression analysis. We were able to describe multifocal intussusceptive neoangiogenesis and vascular sprouting as the three‐dimensional correlate of progressive PCH, a process dividing pre‐existing vessels by intravascular pillar formation previously only known from embryogenesis and tumor neoangiogenesis. Our findings suggest that venous occlusions in PVOD increase shear and stretching forces in the pulmonary capillary bloodstream and thereby induce intussusceptive neoangiogenesis. These findings can serve as a basis for novel approaches to the analysis of PVOD.  相似文献   

    

Hee‐Won Jung  Hyunchul Roh  Younggun Cho  Jinyong Jeong  Young‐Sik Shin  Jae‐Young Lim  Jack M. Guralnik  Jihong Park 《Journal of the American Geriatrics Society》2019,67(12):2605-2609

  相似文献   

    

Ju‐Yeon Lee  Young‐Chul Chung  Seon‐Young Kim  Jae‐Min Kim  Il‐Seon Shin  Jin‐Sang Yoon  Sung‐Wan Kim 《Asia-Pacific psychiatry》2019,11(3)

  相似文献   

    

Takashi Okumura  Kenoki Ohuchida  Shin Kibe  Chika Iwamoto  Yohei Ando  Shin Takesue  Hiromichi Nakayama  Toshiya Abe  Sho Endo  Kazuhiro Koikawa  Masafumi Sada  Kohei Horioka  Naoki Mochidome  Makoto Arita  Taiki Moriyama  Kohei Nakata  Yoshihiro Miyasaka  Takao Ohtsuka  Kazuhiro Mizumoto  Yoshinao Oda  Makoto Hashizume  Masafumi Nakamura 《International journal of cancer. Journal international du cancer》2019,144(6):1401-1413

Although recent studies revealed that adipose tissue accelerates pancreatic tumor progression with excessive extracellular matrix, key players for desmoplasia in the adipose microenvironment remains unknown. Here, we investigated the roles of adipose tissue-derived stromal cells (ASCs) in desmoplastic lesions and tumor progression by in vitro and in vivo experiments. In a three-dimensional (3-D) organotypic fat invasion model using visceral fat from CAG-EGFP mice, GFP-positive fibroblastic cells infiltrated toward cancer cells. When tumor cells were inoculated into transplanted visceral fat pads in vivo, tumor weights and stromal components were enhanced compared to subcutaneous and orthotopic tumor cells inoculated without fat pads. Expression of αSMA in established human ASCs was lower compared to cancer associated fibroblasts, and the 3-D collagen matrices produced by ASCs cultured in cancer cell-conditioned medium changed from loose to dense structures that affected the motility of cancer cells. Microarray analyses revealed upregulation of S100A4 in ASCs, while S100A4-positive stromal cells were observed at extrapancreatic invasion sites of human pancreatic cancer. The present findings indicate that ASCs are recruited to extrapancreatic invasion sites and produce dense collagen matrices that lead to enhanced tumor progression. Both inhibition of ASCs recruitment and activation could lead to a novel antistromal therapy.  相似文献   

    

Sun Hye Shin  Hye Yun Park  Yunjoo Im  Hyun Ae Jung  Jong-Mu Sun  Jin Seok Ahn  Myung-Ju Ahn  Keunchil Park  Ho Yun Lee  Se-Hoon Lee 《International journal of cancer. Journal international du cancer》2019,145(9):2433-2439

Emerging immune profiling data suggest a higher sensitivity to immune checkpoint inhibitors (ICIs) in nonsmall cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD), compared to those without COPD. This study aimed to investigate the clinical impact of COPD on the treatment response to ICIs in a large number of patients with NSCLC. In total, 133 patients with spirometry test results were retrospectively identified among those who received palliative pembrolizumab for NSCLC. COPD was defined as pre-bronchodilator forced expiratory volume in 1 s/forced vital capacity <0.7. Overall survival (OS), progression-free survival (PFS), and objective response rate were analyzed according to the presence of COPD. Spirometry-based COPD was present in 59 (44%) patients. Patients with COPD had better OS (hazard ratio [HR] for death, 0.45; 95% confidence interval [CI], 0.26–0.78) and PFS (HR for disease progression or death, 0.50; 95% CI, 0.31–0.79) than those without COPD. These associations persisted after adjusting for potential confounders including smoking history. The response rate was also higher in patients with COPD than in those without COPD (38.2% vs. 20.5%, p = 0.028). Spirometry-defined COPD was associated with a significantly longer OS and PFS in patients with NSCLC treated with palliative pembrolizumab. Identifying coexisting COPD could predict favorable treatment outcomes in patients with NSCLC treated with pembrolizumab.  相似文献   

    

Jinyoung Shin  Hyeonyoung Ko  Yoon‐Ho Choi  Inyoung Choi  Yun‐Mi Song 《European journal of cancer care》2019,28(6)

  相似文献   

    

Wataru Usuba  Fumihiko Urabe  Yusuke Yamamoto  Juntaro Matsuzaki  Hideo Sasaki  Makiko Ichikawa  Satoko Takizawa  Yoshiaki Aoki  Shumpei Niida  Ken Kato  Shin Egawa  Tatsuya Chikaraishi  Hiroyuki Fujimoto  Takahiro Ochiya 《Cancer science》2019,110(1):408-419

Bladder cancer is the 9th leading cause of cancer death worldwide. The major problem in bladder cancer is primarily the high recurrence rate after drug treatment and resection. Although conventional screening methods, such as cystoscopy, urinary cytology and ultrasound sonography, have become widely used in clinical settings, the diagnostic performance of these modalities is unsatisfactory due to low accuracy or high invasiveness. Because circulating micro RNA (miRNA) profiles have recently been reported as an attractive tool for liquid biopsy in cancer screening, here, we performed global miRNA profiling of 392 serum samples of bladder cancer patients with 100 non‐cancer samples and 480 samples of other types of cancer as controls. We randomly classified the bladder cancer and control samples into 2 cohorts, a training set (N = 486) and a validation set (N = 486). By comparing both controls, we identified specific miRNA, such as miR‐6087, for diagnosing bladder cancer in the training and validation sets. Furthermore, we found that a combination of 7 miRNA (7‐miRNA panel: miR‐6087, miR‐6724‐5p, miR‐3960, miR‐1343‐5p, miR‐1185‐1‐3p, miR‐6831‐5p and miR‐4695‐5p) could discriminate bladder cancer from non‐cancer and other types of tumors with the highest accuracy (AUC: .97; sensitivity: 95%; specificity: 87%). The diagnostic accuracy was high, regardless of the stage and grade of bladder cancer. Our data demonstrated that the 7‐miRNA panel could be a biomarker for the specific and early detection of bladder cancer.  相似文献   

    

Tomonori Iyoda  Satoru Yamasaki  Masami Kawamura  Motoki Ueda  Kon Son  Yoshihiro Ito  Kanako Shimizu  Shin‐ichiro Fujii 《Cancer science》2019,110(3):875-887

Recent immunotherapies have shown clinical success. In particular, vaccines based on particulate antigen (Ag) are expected to be implemented based on their efficacy. In the current study, we describe a strategy entailing Ag‐encapsulating PEG‐modified liposomes (PGL‐Ag) as antigen protein delivery devices and show that the success of the liposome depends on the antigen‐presenting cell (APC) capacity; after administration of PGL‐Ag, dendritic cells (DCs) in particular take up the Ag and subsequently prime T cells. For the generation of antitumor T cell responses in the lymphoid tissues, the function of encapsulated Ag‐capturing DCs in vivo could be a biomarker. We next designed a prime‐boost strategy to enhance the antitumor effects of the PGL‐Ag. In the tumor sites, we show that Ag retention in nanoparticle‐capturing DCs promotes a robust antitumor response. Thus, this efficient particulate Ag‐based host antigen‐presenting cell delivery strategy provides a bridge between innate and adaptive immune response and offers a novel therapeutic option against tumor cells.  相似文献   

    

Shiho Ueda  Hidemi Hayashi  Takako Miyamoto  Shinya Abe  Kana Hirai  Kanji Matsukura  Hideki Yagi  Yuta Hara  Kinji Yoshida  Shogo Okazaki  Masakazu Tamura  Yuki Abe  Toshinori Agatsuma  Shin‐ichiro Niwa  Kazue Masuko  Takashi Masuko 《Cancer science》2019,110(2):674-685

l ‐Type amino acid transporter 1 (LAT1) disulfide linked to CD98 heavy chain (hc) is highly expressed in most cancer cells, but weakly expressed in normal cells. In the present study, we developed novel anti‐LAT1 mAbs and showed internalization activity, inhibitory effects of amino acid uptake and cell growth and antibody‐dependent cellular cytotoxicity, as well as in vivo antitumor effects in athymic mice. Furthermore, we examined the reactivity of mAbs with LAT1 of Macaca fascicularis to evaluate possible side‐effects of antihuman LAT1 mAbs in clinical trials. Antihuman LAT1 mAbs reacted with ACHN human and MK.P3 macaca kidney‐derived cells, and this reactivity was significantly decreased by siRNAs against LAT1. Macaca LAT1 cDNA was cloned from MK.P3, and only two amino acid differences between human and macaca LAT1 were seen. RH7777 rat hepatoma and HEK293 human embryonic kidney cells expressing macaca LAT1 were established as stable transfectants, and antihuman LAT1 mAbs were equivalently reactive against transfectants expressing human or macaca LAT1. Dual (high and low) avidity modes were detected in transfectants expressing macaca LAT1, MK.P3, ACHN and HCT116 human colon cancer cells, and K_A values were increased by anti‐CD98hc mAb, suggesting anti‐LAT1 mAbs detect an epitope on LAT1‐CD98hc complexes on the cell surface. Based on these results, LAT1 may be a promising anticancer target and Macaca fascicularis can be used in preclinical studies with antihuman LAT1 mAbs.  相似文献