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101.
Kuriyama M Kato J Kuwaki K Morimoto N Nawa T Fujimoto T Kono H Okano N Miyaike J Morita T Okada H Suzuki S Yoshioka T Shiode J Suwaki K Sakaguchi K Shiratori Y;Japan West Ulcerative Colitis Study Group 《European journal of gastroenterology & hepatology》2008,20(7):634-641
BACKGROUND AND AIM: The health-related quality of life (HRQOL) of patients with ulcerative colitis (UC) can be impaired because of the chronic symptoms. Although UC patients suffer from such symptoms over the long term, there have been few reports on the changes of HRQOL with disease duration. The aim of this study was to clarify these changes. METHODS: The HRQOL of 331 Japanese UC patients was examined using the validated Japanese version of the Inflammatory Bowel Disease Questionnaire (J-IBDQ). HRQOL and factors affecting HRQOL identified using multiple linear regression analysis were stratified by disease duration. RESULTS: Of the 15 clinical factors examined, the clinical activity index score was the strongest determinant (P<0.0001) of all the scores of IBDQ regardless of disease duration. HRQOL did not differ significantly among patients with different disease durations. The factors, however, that affected HRQOL varied according to disease duration. In patients with disease duration of less than 5 years, the clinical activity index score was the predominant factor affecting HRQOL. Being 'on sick leave or hospitalized' was a significant factor impairing HRQOL in patients with disease duration of 5-9 years. Moreover, complications due to corticosteroids significantly impaired all of the IBDQ scores in patients with disease duration of 10 years or more. CONCLUSION: Factors that affected the HRQOL of UC patients varied according to the patients' disease duration. Our findings should assist in the development of a long-term strategy for the treatment of UC patients. 相似文献
102.
Different outcomes of vertical transmission of hepatitis C virus in a twin pregnancy 总被引:4,自引:0,他引:4
Inui A Fujisawa T Sogo T Komatsu H Isozaki A Sekine I 《Journal of gastroenterology and hepatology》2002,17(5):617-619
The risk of vertical transmission of hepatitis C virus (HCV) from mother to infant has been well documented, but the exact mode of transmission is still unclear. In a set of monochorionic diamniotic monozygous twins, only the second baby was infected with HCV from the mother who was positive for serum HCV-RNA. The babies had an uncomplicated vaginal delivery 3 min apart and they were both bottle fed from the outset. The second baby developed clinical hepatitis that persisted to 30 months follow up. The intrauterine environment should have been identical for these twins, and therefore, the maternal HCV factors, including viral load are not the sole determining factors for mother-to-infant transmission of HCV. 相似文献
103.
Yoneda M Sanada H Yatabe J Midorikawa S Hashimoto S Sasaki M Katoh T Watanabe T Andrews PM Jose PA Felder RA 《Hypertension》2005,46(1):58-65
The effect of selectively decreasing renal angiotensin II type 1 (AT1) receptor expression on renal function and blood pressure has not been determined. Therefore, we studied the consequences of selective renal inhibition of AT1 receptor expression in normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) in vivo. Vehicle, AT1 receptor antisense oligodeoxynucleotides (AS-ODN), or scrambled oligodeoxynucleotides were infused chronically into the cortex of the remaining kidney of conscious, uninephrectomized WKY and SHR on a 4% NaCl intake. Basal renal cortical membrane AT1 receptor protein was greater in SHR than in WKY. In WKY and SHR, AS-ODN decreased renal but not cardiac AT1 receptors. AT1 receptor AS-ODN treatment increased plasma renin activity to a greater extent in WKY than in SHR. However, plasma angiotensin II and aldosterone were increased by AS-ODN to a similar degree in both rat strains. In SHR, sodium excretion was increased and sodium balance was decreased by AS-ODN but had only a transient ameliorating effect on blood pressure. Urinary protein and glomerular sclerosis were markedly reduced by AS-ODN-treated SHR. In WKY, AS-ODN had no effect on sodium excretion, blood pressure, or renal histology but also modestly decreased proteinuria. The major consequence of decreasing renal AT1 receptor protein in the SHR is a decrease in proteinuria, probably as a result of the amelioration in glomerular pathology but independent of systemic blood pressure and circulating angiotensin II levels. 相似文献
104.
According to the report of MORE trial, raloxifene (RLX) compensate for the faults of hormone replacement therapy with the reasons following below; 1) RLX inhibits onset of breast cancer with estrogen receptor remarkably, 2) RLX inhibits onset of cardiovascular disease in its high risk group. However, because RLX has a elevated risk of venous thrombosis as same as hormone replacement therapy, we should give attention to this disease at the use of RLX. 相似文献
105.
A Large Retroperitoneal Encapsulation of Bile from a Spontaneous Perforation of the Common Bile Duct
Katsusuke Satake M.D. F.A.C.S. Teruyuki Ikehara M.D. Keiho Shim M.D. Tsuyoshi Asai M.D. Kaoru Umeyama M.D. Michio Yoshioka Hiroshi Takemura M.D. 《The American journal of gastroenterology》1985,80(4):279-283
We report a patient with spontaneous rupture of the common bile duct. This is an extremely rare condition which produces free leakage of bile into the peritoneal cavity. There has been no previous report concerning the formation of a large retroperitoneal encapsulation of bile. The preoperative diagnosis in our patient was very difficult and endoscopic retrograde pancreatocholangiography and cystography by ultrasound guidance were helpful. 相似文献
106.
Dai?Okayama Tsuyoshi?Suzuki Tsuyoshi?ShigaEmail author Yuichiro?Minami Shuichi?Tsuruoka Nobuhisa?Hagiwara 《Am J Cardiovasc Drugs》2015,15(4):289-293
Introduction
Arginine vasopressin-stimulated reabsorption of urea occurs in the collecting duct via increased expression of the urea transporter.Objective
The aim of this study was to evaluate whether the blood urea nitrogen/creatinine (BUN/Cr) ratio is useful for predicting tolvaptan response in patients with decompensated heart failure (HF).Methods
Among 71 consecutive patients with HF who received oral tolvaptan between 2010 and 2014, we retrospectively studied 33 patients with decompensated HF without any mechanical circulatory assistance or inotropic support who had already been treated with loop diuretics. A responder to tolvaptan was defined as an individual who experienced a ≥30 % increase in their respective 24-h urine volume.Results
Among the 33 patients, 21 met the criteria of a responder. The area under the receiver operating characteristic curves of BUN/Cr and BUN were 0.790 and 0.714, respectively, and the respective cut-off values for responders to tolvaptan were 23.8 and 49.0. BUN/Cr and BUN retained their significant relationships with the responder status (odds ratio for BUN/Cr >23.8: 20.9; 95 % confidence interval [CI] 2.7–531.1; p = 0.002; odds ratio for BUN ≥49: 7.7; 95 % CI 1.4–65.8; p = 0.02).Conclusion
Our results suggest that high BUN/Cr may be a predictor of response to tolvaptan in decompensated HF patients. A prospective study with a large sample size is required to confirm this preliminary finding.107.
Atsushi Yoshimura Mitsuru Kimura Sachio Matsushita Jun-ichi Yoneda Hitoshi Maesato Yasunobu Komoto Hideki Nakayama Hiroshi Sakuma Yosuke Yumoto Tsuyoshi Takimura Tomomi Tohyama Chie Iwahara Takeshi Mizukami Akira Yokoyama Susumu Higuchi 《Alcoholism, clinical and experimental research》2021,45(11):2335-2346
108.
Mature male Japanese quail were transferred from 16L:8D (19 degrees) to one of the following combinations of daily light-dark and temperature cycles, 8L:16D (12 hr, 19 degrees:12 hr, 9 degrees), 12L:12D (12 hr, 19 degrees:12 hr, 9 degrees) and 12L:12D (16 hr, 19 degrees:8 hr, 9 degrees). The low temperature is for the middle of the dark period in each treatment. In the control groups, birds were transferred to the same photoperiodic conditions as the experimental groups, but without changes in ambient temperature. Blood samples were collected every other day for 30 days and circulating levels of plasma LH were estimated by radioimmunoassay. Both the change in conditions from 16L:8D to 8L:16D with the temperature lowered for 12 hr and that from 16L:8D to 12L:12D with temperatures lowered in one case for 12 hr and in the other for 8 hr caused a lowering in plasma LH levels in all the birds to reproductively quiescent levels. The cloacal protrusion of all these birds regressed completely. In control groups, however, most if not all the birds remained in active breeding states although the levels of circulating LH decreased to basal breeding levels of 1-2 ng/ml. The results indicated that in addition to a change from long to short days an alternation of high and low temperatures was sufficient supplementary information in causing termination of LH secretion and inducing regression of the gonads and the accessory sex organs in this species. 相似文献
109.
Yoshihisa Yaguchi Tsuyoshi Inaba Yoshimasa Kumata Masahiro Horikawa Takashi Kiyokawa Ryoji Fukushima 《Asian journal of endoscopic surgery》2018,11(1):71-74
We performed transabdominal preperitoneal inguinal hernia repair in 46 patients (58 diseases), two of whom experienced early recurrence after mesh repair. Case 1 was a 76‐year‐old man with a bilateral inguinal hernia (recurrence site, left indirect hernia) after appendectomy. The recurrence occurred 1 month after transabdominal preperitoneal inguinal hernia repair. The mesh was dislocated to the lateral side, and we repaired it using the direct Kugel ® patch with an anterior technique. Case 2 was a 79‐year‐old man with a bilateral inguinal hernia (recurrence site, right direct hernia with an orifice >3 cm) after appendectomy. The recurrence occurred 3 months after transabdominal preperitoneal inguinal hernia repair. The mesh was dislocated to the lateral side, and we repaired it using an ULTRAPRO ® Plug with an anterior technique under laparoscopic observation. We believe the recurrences resulted from insufficient internal exfoliation and fixation affected by complicated exfoliation of the preperitoneal space with omental adhesion after intraperitoneal surgery. 相似文献
110.
Akihiko?Inoue Toru?Hifumi Yasuhiro?Kuroda Naoki?Nishimoto Kenya?Kawakita Susumu?Yamashita Yasutaka?Oda Kenji?Dohi Hitoshi?Kobata Eiichi?Suehiro Tsuyoshi?Maekawa 《Critical care (London, England)》2018,22(1):352