全文获取类型
收费全文 | 2897篇 |
免费 | 205篇 |
国内免费 | 51篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 126篇 |
妇产科学 | 63篇 |
基础医学 | 306篇 |
口腔科学 | 56篇 |
临床医学 | 260篇 |
内科学 | 556篇 |
皮肤病学 | 38篇 |
神经病学 | 353篇 |
特种医学 | 200篇 |
外科学 | 362篇 |
综合类 | 70篇 |
一般理论 | 1篇 |
预防医学 | 160篇 |
眼科学 | 144篇 |
药学 | 277篇 |
1篇 | |
中国医学 | 14篇 |
肿瘤学 | 154篇 |
出版年
2023年 | 16篇 |
2022年 | 21篇 |
2021年 | 73篇 |
2020年 | 39篇 |
2019年 | 58篇 |
2018年 | 78篇 |
2017年 | 62篇 |
2016年 | 66篇 |
2015年 | 75篇 |
2014年 | 99篇 |
2013年 | 129篇 |
2012年 | 176篇 |
2011年 | 205篇 |
2010年 | 111篇 |
2009年 | 130篇 |
2008年 | 142篇 |
2007年 | 194篇 |
2006年 | 138篇 |
2005年 | 106篇 |
2004年 | 73篇 |
2003年 | 83篇 |
2002年 | 67篇 |
2001年 | 71篇 |
2000年 | 62篇 |
1999年 | 56篇 |
1998年 | 86篇 |
1997年 | 93篇 |
1996年 | 64篇 |
1995年 | 57篇 |
1994年 | 42篇 |
1993年 | 50篇 |
1992年 | 38篇 |
1991年 | 22篇 |
1990年 | 24篇 |
1989年 | 41篇 |
1988年 | 34篇 |
1987年 | 49篇 |
1986年 | 29篇 |
1985年 | 26篇 |
1984年 | 20篇 |
1983年 | 16篇 |
1982年 | 14篇 |
1981年 | 12篇 |
1980年 | 12篇 |
1979年 | 8篇 |
1977年 | 13篇 |
1975年 | 10篇 |
1974年 | 8篇 |
1971年 | 9篇 |
1969年 | 7篇 |
排序方式: 共有3153条查询结果,搜索用时 265 毫秒
81.
82.
83.
Factor V Quebec revisited 总被引:2,自引:5,他引:2
Factor V Quebec has been described as a bleeding disorder that exhibits an autosomal dominant inheritance pattern and presents severe bleeding after trauma. Two members of a fourth-generation (IV.13 and IV.15) Canadian family have been studied in detail and are the subject of this report. Their clinical presentations and histories have been described previously (Tracy et al: J Clin Invest 74:1221, 1984). Persistent abnormalities include mild thrombocytopenia and defective platelet factor V. Plasma factor V is present at near normal concentration and is fully functional. Thus, the bleeding diathesis appears to reflect the absence of platelet factor V activity. The recent report (Hayward et al: Blood 84:110a, 1994 [suppl, abstr]) of multimerin deficiency in these individuals led us to reevaluate these patients. Western blot analyses of platelet lysates developed with a variety of monoclonal antibodies show that the alpha-granule proteins, fibrinogen, von Willebrand factor, factor V and osteonectin are decreased in concentration and significantly degraded in the platelets of these patients. Thrombospondin, while not degraded, is substantially decreased. In contrast, platelet factor 4 and beta-thromboglobulin do not appear to be affected. These observations suggest that the alpha- granules are correctly assembled but the contents are subsequently subjected to proteolytic degradation. The results indicate that factor V Quebec disorder is probably associated with a generalized defect that leads to degradation of most proteins of the alpha-granules. 相似文献
84.
85.
Domenico G. Della Rocca MD Michele Magnocavallo MD Veronica N. Natale MPH Carola Gianni MD PhD Sanghamitra Mohanty MD Chintan Trivedi MD MPH Carlo Lavalle MD Giovanni B. Forleo MD PhD Nicola Tarantino MD Jorge Romero MD Xiadong Zhang MD Mohamed Bassiouny MD Amin Al-Ahmad MD David J. Burkhardt MD Joseph G. Gallinghouse MD Javier E. Sanchez MD Rodney P. Horton MD Luigi Di Biase MD PhD Andrea Natale MD 《Journal of cardiovascular electrophysiology》2021,32(9):2441-2450
86.
Kirsti A. Campbell Hirsh D. Trivedi Sanjiv Chopra 《The American journal of medicine》2021,134(6):727-734
Cirrhosis contributes significantly to morbidity and mortality worldwide. Infections in patients with cirrhosis are common and significantly impact health-related quality of life. As our understanding of immune dysfunction associated with cirrhosis grows and as rates of drug-resistant organisms increase, the management of infections in cirrhosis has become increasingly nuanced. In this review, we discuss the current understanding of cirrhosis-associated immune deficiency, review the most common infections in patients with cirrhosis, and highlight techniques for the general clinician in the prevention and treatment of infections in this high-risk population. 相似文献
87.
88.
CL Sanchez CS Biskup S Herpertz TJ Gaber CM Kuhn SH Hood FD Zepf 《The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)》2015,18(10)
The neurotransmitters serotonin and dopamine both have a critical role in the underlying neurobiology of different behaviors. With focus on the interplay between dopamine and serotonin, it has been proposed that dopamine biases behavior towards habitual responding, and with serotonin offsetting this phenomenon and directing the balance toward more flexible, goal-directed responding. The present focus paper stands in close relationship to the publication by Worbe et al. (2015), which deals with the effects of acute tryptophan depletion, a neurodietary physiological method to decrease central nervous serotonin synthesis in humans for a short period of time, on the balance between hypothetical goal-directed and habitual systems. In that research, acute tryptophan depletion challenge administration and a following short-term reduction in central nervous serotonin synthesis were associated with a shift of behavioral performance towards habitual responding, providing further evidence that central nervous serotonin function modulates the balance between goal-directed and stimulus-response habitual systems of behavioral control. In the present focus paper, we discuss the findings by Worbe and colleagues in light of animal experiments as well as clinical implications and discuss potential future avenues for related research. 相似文献
89.
Dziennis S; Van Etten RA; Pahl HL; Morris DL; Rothstein TL; Blosch CM; Perlmutter RM; Tenen DG 《Blood》1995,85(2):319-329
CD11b is the alpha chain of the Mac-1 integrin and is preferentially expressed in myeloid cells (neutrophils, monocytes, and macrophages). We have previously shown that the CD11b promoter directs cell-type- specific expression in myeloid lines using transient transfection assays. To confirm that these promoter sequences contain the proper regulatory elements for correct myeloid expression of CD11b in vivo, we have used the -1.7-kb human CD11b promoter to direct reporter gene expression in transgenic mice. Stable founder lines were generated with two different reporter genes, a Thy 1.1 surface marker and the Escherichia coli lacZ (beta-galactosidase) gene. Analysis of founders generated with each reporter demonstrated that the CD11b promoter was capable of driving high levels of transgene expression in murine macrophages for the lifetime of the animals. Similar to the endogenous gene, transgene expression was preferentially found in mature monocytes, macrophages, and neutrophils and not in myeloid precursors. These experiments indicate that the -1.7 CD11b promoter contains the regulatory elements sufficient for high-level macrophage expression. This promoter should be useful for targeting heterologous gene expression to mature myeloid cells. 相似文献
90.