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21.
Anne Schneider Snehajyoti Chatterjee Olivier Bousiges B. Ruthrotha Selvi Amrutha Swaminathan Raphaelle Cassel Frédéric Blanc Tapas K. Kundu Anne-Laurence Boutillier 《Neurotherapeutics》2013,10(4):568-588
The acetylation of histone and non-histone proteins controls a great deal of cellular functions, thereby affecting the entire organism, including the brain. Acetylation modifications are mediated through histone acetyltransferases (HAT) and deacetylases (HDAC), and the balance of these enzymes regulates neuronal homeostasis, maintaining the pre-existing acetyl marks responsible for the global chromatin structure, as well as regulating specific dynamic acetyl marks that respond to changes and facilitate neurons to encode and strengthen long-term events in the brain circuitry (e.g., memory formation). Unfortunately, the dysfunction of these finely-tuned regulations might lead to pathological conditions, and the deregulation of the HAT/HDAC balance has been implicated in neurological disorders. During the last decade, research has focused on HDAC inhibitors that induce a histone hyperacetylated state to compensate acetylation deficits. The use of these inhibitors as a therapeutic option was efficient in several animal models of neurological disorders. The elaboration of new cell-permeant HAT activators opens a new era of research on acetylation regulation. Although pathological animal models have not been tested yet, HAT activator molecules have already proven to be beneficial in ameliorating brain functions associated with learning and memory, and adult neurogenesis in wild-type animals. Thus, HAT activator molecules contribute to an exciting area of research. 相似文献
22.
Journal of Autism and Developmental Disorders - Adolescents with ASD face challenges in forming positive friendships due to their ASD condition. This study developed a social networking platform... 相似文献
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Present communication reports the effects of environmentally available, low doses of tetra chloro di benzo-p-dioxin (2,3,7,8 TCDD) to lysosomal enzymes in mice liver. The study tests the hypothesis, in vivo exposure of low dose TCDD provokes dose and duration dependent toxic effects to key lysosomal enzymes and thereby causes cellular apoptotic changes. Three groups of female Swiss albino mice were subjected to two doses of TCDD (0.004 mg/kg bw/d, 0.04 mg/kg bw/d) for 2, 4 and 6 days of exposure durations. The results indicated significant exposure duration dependent effects of TCDD in mice liver cells. The results suggested that TCDD possibly induced an increase in intracellular ions or ROS which in turn altered different physiological activities by affecting different metabolic pathway of the liver cells. The altered functions of key lysosomal enzymes by TCDD may also evoke the process of cellular apoptosis. 相似文献
25.
Protein misfolding and fibrillation are the fundamental traits in degenerative diseases like Alzheimer''s, Parkinsonism, and diabetes mellitus. Bioactives such as flavonoids and terpenoids from plant sources are known to express protective effects against an array of diseases including diabetes, Alzheimer''s and obesity. Andrographolide (AG), a labdane diterpenoid is prescribed widely in the Indian and Chinese health care systems for classical efficacy against a number of degenerative diseases. This work presents an in depth study on the effects of AG on protein fibrillating pathophysiology. Thioflavin T fluorescence spectroscopy and DLS results indicated concentration dependent inhibition of human serum albumin (HSA) fibrillation. The results were confirmed by electron microscopy studies. HSA fibril formations were markedly reduced in the presence of AG. Fluorescence studies and UV-Vis experiments confirmed further that AG molecularly interacts with HSA at site. In silico molecular docking studies revealed hydrogen bonding and hydrophobic interactions with HSA in the native state. Thus AG interacts with HSA, stabilizes the native protein structure and inhibits fibrillation. The results demonstrated that the compound possesses anti-amyloidogenic properties and can be promising against some human degenerative diseases.Andrographolide inhibited HSA protein fibrillation through site specific interactions. 相似文献
26.
Putatunda Chayanika Kundu B. S. Bhatia Ranjana 《Proceedings of the National Academy of Sciences, India. Section B.》2019,89(3):957-965
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - Proteolytic enzymes form a very significant group of enzymes which are used for a variety of purposes... 相似文献
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Trina E. Orimoto Charles W. Mueller Kentaro Hayashi Brad J. Nakamura 《Administration and policy in mental health》2014,41(2):262-275
Little is known about the types of psychotherapeutic practices delivered to youth with comorbid and multimorbid diagnoses in community settings. The present study, based on therapists’ self-reported practices with 569 youth diagnosed with a disruptive behavior disorder (ODD or CD), examined whether specific therapeutic practice applications varied as a function of the number and type of comorbid disorders. While type of comorbid disorder (AD/HD or internalizing) did not predict therapists’ practices, youth with more than two diagnoses (multimorbid) received treatment characterized by a more diverse set and a higher dosage of practices. 相似文献
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30.
Tanjore Balganesh TapasK. Kundu Tushar Kanti Chakraborty Siddhartha Roy 《ACS medicinal chemistry letters》2014,5(7):724-726
Indian civilization developed a strong
system of traditional medicine
and was one of the first nations to develop a synthetic drug. In the
postindependence era, Indian pharmaceutical industry developed a strong
base for production of generic drugs. Challenges for the future are
to give its traditional medicine a strong scientific base and develop
research and clinical capability to consistently produce new drugs
based on advances in modern biological sciences.Indian civilization
is one of
the few in the world that developed a full-fledged system of traditional
medicine. The approach of Indian traditional medicine, e.g., the ayurvedic
system, is herbal based in general and is more effective for chronic
diseases and prevention. Although modern medicine has found its own
niche in India, traditional formulations are still widely used, and
more and more scientifically validated formulations are appearing
in the market. In recent times, many plants used in Indian system
of medicine have been analyzed by modern analytical methods and active
components have been isolated. Significant amount of medicinal chemistry
efforts are going on around these molecules in an attempt to develop
more potent leads. These include curcumin from turmeric,1 Bacosides from Brahmi (Bacopa monnieri),2 and Forskolin from Coleus
forskohlii. The first modern synthetic drug to be developed
in India was Urea Stibamine in 1922 by UN Brahmachari against visceral
leishmaniasis.3 Visceral leishmaniasis
was a severe health burden during the early part of the 20th century,
and it was a life saving drug for a large section of the population.
Historically, it was the second drug developed against an infectious
disease after Salversan (against Syphillis) and well before penicillin
or sulfa drugs. It is still in use in many countries in a modified
form. 相似文献