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Jonathan A. Polonsky Joseph F. Wamala Hilde de Clerck Michel Van Herp Armand Sprecher Klaudia Porten Trevor Shoemaker 《The American journal of tropical medicine and hygiene》2014,90(5):790-793
Outbreaks of Ebola and Marburg virus diseases have recently increased in frequency in Uganda. This increase is probably caused by a combination of improved surveillance and laboratory capacity, increased contact between humans and the natural reservoir of the viruses, and fluctuations in viral load and prevalence within this reservoir. The roles of these proposed explanations must be investigated in order to guide appropriate responses to the changing epidemiological profile. Other African settings in which multiple filoviral outbreaks have occurred could also benefit from such information. 相似文献
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Songhua Shan Stan Fenwick Trevor Ellis Eddy Poinern John Edwards Xuan Le 《Avian pathology》2016,45(6):649-656
This study assessed the ability of three adjuvants (aluminium hydroxide, Essai (microparticle) and Phema (nanoparticle)) to enhance the immune response of chickens to an H6N2 avian influenza DNA vaccine. No haemagglutination inhibition antibody was detected following two intramuscular immunizations with the adjuvanted and non-adjuvanted pCAG-HAk vaccine, which has previously been shown to induce moderate H6 haemagglutinin antibody response in SPF chickens. Following virus challenge, neither the vaccinated group without adjuvant nor the Essai-adjuvanted group showed a statistically significant reduction in virus shedding in oropharyngeal and cloacal swabs compared with the naive control group. However, the aluminium hydroxide and Phema-adjuvanted groups significantly reduced the frequency of virus shedding in oropharyngeal swabs, indicating that these adjuvants appeared to further enhance the vaccine potency. Aluminium hydroxide holds promise as an adjuvant for enhancing DNA-induced immune response in chickens owing to its low price and safety record. 相似文献
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Annals of Surgical Oncology - The only curative treatment for localised gastric cancer is surgical resection. However, survival outcomes post-surgery alone remain poor, particularly in those with... 相似文献
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Adam E. Barry Steve Howell Trevor Bopp Michael Stellefson Elizabeth Chaney Anna Piazza-Gardner Caroline Payne-Purvis 《The journal of primary prevention》2014,35(6):409-416
While alcohol consumption has been consistently linked to college football games in the United States, this literature lacks (a) field-based event-level analyses; (b) assessments of the context of drinking, such as days leading to an event, that occurs in conjunction with a contest; (c) investigations of non-student drinking; and (d) objective assessments of opponent rating. Therefore, the present study: (1) examines the extent to which breath alcohol concentrations (BrAC) among restaurant and bar district patrons differ for low- and high-profile games and (2) explores the relationship between an objective rating of a team’s opponent and BrAC levels. Data were collected throughout the fall 2011 football season via six anonymous field studies in a bar district within a southeastern college community. During low-profile game weekends, respondents recorded significantly lower BrAC levels than those during high-profile game weekends. Additionally, there was a positive correlation between opponent rating and BrAC levels, such that mean BrAC readings were highest prior to the game featuring the highest rated opponent. Overall, participants exhibited significantly higher BrACs when a higher-rated opponent was playing that weekend. When resources (money, manpower) are limited, community-based prevention and enforcement efforts should occur during the weekends surrounding higher-profile games. 相似文献
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Understanding the neurochemical basis for cognitive function is one of the major goals of neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range of psychiatric and neurological disorders. In this review, the focus will be on a biochemical pathway that remains under-recognized in its implications for brain function, even though it can be responsible for moderating the activity of two neurotransmitters fundamentally involved in cognition – glutamate and acetylcholine. Since this pathway – the kynurenine pathway of tryptophan metabolism – is induced by immunological activation and stress, it also stands in a unique position to mediate the effects of environmental factors on cognition and behaviour. Targeting the pathway for new drug development could, therefore, be of value not only for the treatment of existing psychiatric conditions, but also for preventing the development of cognitive disorders in response to environmental pressures. 相似文献