指数程序升温药物稳定性试验

介绍了一种新的程序升温(指数程序升温)药物稳定性预测加速试验方法及计算方法。在这一新的程序升温方法中,温度每升高10℃,升温速率将增大2～4倍:dT/dt=a^(T-T₀)/10·(dT/dt)₀,使药物在高温和低温范围内的降解程度尽可能一致,提高了试验准确度。采用单因素优选法和数值积分法处理试验数据,避免了任何近似处理,使计算结果准确可靠。与线性升温、倒数升温和对数升温加速试验进行了对比,结果表明,指数程序升温法的准确性优于其它3种升温法。     

A general, computer-based method for study of the spatial distribution of muscle fiber types in skeletal muscle

Summary The present method provides detailed quantitative information on the spatial distribution of the muscle fiber types in skeletal muscle. This is accomplished by comparing the measured spatial distribution of the fiber types with a computer-simulated random pattern. The method is based on a registration of the absolute frequency for six principal categories of fiber contacts (I-I, I-IIA, I-IIB, IIA-IIA, IIA-IIB, IIB-IIB). A computer program was designed tosimulate a random pattern of fibers. The simulations were performed with high accuracy with regard to fiber type proportion and the number of neighbouring fibers. The computer then calculated the frequency for each of the different categories of fiber contacts in the simulated random pattern. The measured distribution of fiber contacts could thus be compared to the simulated random pattern. In three bovine muscles studied, the spatial distribution of the muscle fiber types showed a similar pattern. The muscle fibers had a distinct tendency to be surrounded by fibers of a different type. In all three muscles the difference between the measured and the simulated random pattern was statistically significant (p<10^-3).     

Relationship of Psychosocial Risk Factors, Certain Personality Traits and Myocardial Infarction in Indians: A Case�Ccontrol Study

Objective:

To investigate the relationship of psychosocial factors (lack of social support, stress and subjective well-being) and personality traits with myocardial infarction (MI).

Materials and Methods:

A case–control study involving 100 cases and 100 matched controls was conducted in Lok Nayak Hospital, New Delhi.

Results:

Stress over 1 year was significantly higher in cases (P < 0.001). However, difference was not significant when scores of social support (P = 0.2), Presumptive Stressful Life Event (PSLE) over lifetime (P = 0.058) and subjective well-being (P = 0.987) were compared. MI was significantly associated with hyperactive (P < 0.001), dominant (P = 0.03), egoistic (P < 0.001) and introvert (P < 0.001) personalities.

Conclusion:

Certain personality traits and recent stress may be important risk factors of MI, especially in Indians. The finding may have implications on the preventive strategies planned for MI patients.