全文获取类型
收费全文 | 10441篇 |
免费 | 529篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 106篇 |
儿科学 | 197篇 |
妇产科学 | 200篇 |
基础医学 | 1317篇 |
口腔科学 | 266篇 |
临床医学 | 756篇 |
内科学 | 2653篇 |
皮肤病学 | 167篇 |
神经病学 | 625篇 |
特种医学 | 373篇 |
外科学 | 1515篇 |
综合类 | 54篇 |
一般理论 | 3篇 |
预防医学 | 344篇 |
眼科学 | 259篇 |
药学 | 794篇 |
中国医学 | 11篇 |
肿瘤学 | 1370篇 |
出版年
2023年 | 64篇 |
2022年 | 131篇 |
2021年 | 230篇 |
2020年 | 112篇 |
2019年 | 158篇 |
2018年 | 172篇 |
2017年 | 143篇 |
2016年 | 201篇 |
2015年 | 188篇 |
2014年 | 222篇 |
2013年 | 320篇 |
2012年 | 514篇 |
2011年 | 512篇 |
2010年 | 300篇 |
2009年 | 269篇 |
2008年 | 460篇 |
2007年 | 530篇 |
2006年 | 492篇 |
2005年 | 513篇 |
2004年 | 471篇 |
2003年 | 447篇 |
2002年 | 448篇 |
2001年 | 351篇 |
2000年 | 351篇 |
1999年 | 304篇 |
1998年 | 140篇 |
1997年 | 105篇 |
1996年 | 94篇 |
1995年 | 85篇 |
1994年 | 86篇 |
1993年 | 63篇 |
1992年 | 246篇 |
1991年 | 228篇 |
1990年 | 241篇 |
1989年 | 224篇 |
1988年 | 195篇 |
1987年 | 159篇 |
1986年 | 152篇 |
1985年 | 141篇 |
1984年 | 88篇 |
1983年 | 85篇 |
1981年 | 51篇 |
1979年 | 67篇 |
1974年 | 38篇 |
1973年 | 54篇 |
1972年 | 50篇 |
1971年 | 48篇 |
1970年 | 43篇 |
1969年 | 71篇 |
1968年 | 53篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
Yasuomi Ouchi Teiji Nakayama Toshihiko Kanno Etsuji Yoshikawa Tomomi Shinke Tatsuo Torizuka 《Journal of cerebral blood flow and metabolism》2007,27(4):803-810
Differentiation of impaired gait seen in idiopathic normal pressure hydrocephalus (iNPH) from parkinsonian gait is sometimes a great challenge and important for future medication in the clinical setting. To investigate dopaminergic contribution to its pathophysiology, two aspects of the trans-synaptic dopamine functions in the striatal region in eight iNPH patients na?ve to dopaminergic drugs were examined using positron emission tomography with a presynaptic marker [11C]CFT ([11C]2-beta-carbomethoxy-3beta-(4-fluorophenyl) tropane) that binds to dopamine transporter and a postsynaptic marker [11C]raclopride that binds to D2 receptor. Quantitative values of binding potentials (BPs) for [11C]CFT and [11C]raclopride were compared between patients and eight age-matched healthy subjects. The BPs and magnetic resonance imaging-based morphometric measures in iNPH were used for correlation analyses between the magnitude of binding of these in vivo markers and clinical severity of the patients. Analysis of variance showed significant reduction in [11C]raclopride binding in the putamen and nucleus accumbens (P<0.05, corrected for multiple comparison) and unchanged striatal [11C]CFT binding in iNPH. The dorsal putamen [11C]raclopride binding correlated negatively with gait severity (r=0.720, P<0.05), and the nucleus accumbens [11C]raclopride binding correlated positively with emotional recognition score (r=0.727, P<0.05) in the disease group. No significant relationship was observed between BPs and morphometric measures. The current result of the postsynaptic D2 receptor reduction along with preserved presynaptic activity in the nigrostriatal dopaminergic system reflects a pathophysiology of iNPH. Postsynaptic D2 receptor hypoactivity in the dorsal putamen may predict the severity of gait impairment in iNPH. 相似文献
12.
13.
Kentaro Tamura Fumikazu Nomura Shogo Mukai Masao Yoshitatsu Jun Sakao Katsuhiko Ihara 《Annals of thoracic and cardiovascular surgery》2003,9(3):206-208
Patients with porcelain aorta carry a high risk of cerebral as well as systemic embolism during cardiac surgery. Here we describe a case of severe aortic stenosis and coronary artery disease combined with the circumferentially calcified aorta. The patient was a 77-year-old man who successfully received four coronary artery bypass grafts with in situ arterial grafts without clamping the aorta and aortic valve replacement. Aortic valve replacement and two distal coronary artery anastomoses to the left circumflex artery and obtuse marginal branch were performed under cardiac arrest during hypothermic perfusion with endoaortic balloon occlusion, followed by partial endarterectomy and closure of the aorta buttressed with bovine pericardium under deep hypothermic circulatory arrest. While rewarming, the other two distal coronary anastomoses to the left anterior descending artery and diagonal branch were done on the beating heart in order to minimize cardiac arrest time. On-pump beating heart coronary artery bypass grafting (CABG) can be useful especially for combined complex cardiac surgery. 相似文献
14.
A 68-year-old man noticed weakness in both legs, which worsened rapidly with additional urinary disturbance. At the time of admission, a neurological examination revealed spastic paraplegia. Sensation was intact. Magnetic resonance imaging (MRI) did not show any lesions in the spinal cord. Thereafter, sensory disturbance under Th5 level and weakness in both hands developed gradually. Seven months after the onset, he noticed pain of the right upper arm. MRI showed an epidural mass at the level between the lower cervical and the upper thoracic spine. Histological examination of the epidural mass revealed Ki-1 lymphoma. In this case, the diagnosis was difficult, because lymphoma did not present epidural mass in the early stage. We speculate that spinal epidural lymphoma might disturb venous circulation and cause myelopathy in this patient. 相似文献
15.
MRI of ossification of ligamentum flavum. 总被引:11,自引:0,他引:11
H Sugimura Y Kakitsubata Y Suzuki S Kakitsubata S Tamura O Uwada T Kodama T Yano K Watanabe 《Journal of computer assisted tomography》1992,16(1):73-76
Magnetic resonance imaging of 28 patients with radiological and/or histopathologically proved ossification of the ligamentum flavum (OLF) was reviewed. The locations of OLF were cervical (n = 4), thoracic (n = 22), and lumbar (n = 2). On T1- and T2-weighted images, OLF demonstrated low signal intensity. Areas of high or intermediate signal intensity within the OLF on T1-weighted images were observed in three cases and were interpreted to be due to fat infiltration. In six cases, high intensity areas in the spinal cord caused by compressing OLF were demonstrated on T2-weighted images. Gadolinium-diethylenetriamine pentaacetic acid, which was used in four cases, showed cord enhancement at the level of compression by OLF in three cases. 相似文献
16.
M Otaki N Kitamura T Miki A Yamaguchi H Tamura 《Kyobu geka. The Japanese journal of thoracic surgery》1990,43(7):533-537
We have obtained the good result about tricuspid annular constriction (TAC) for secondary tricuspid insufficiency. The purpose of this study is to investigate the effectiveness of TAC for the experimental model of tricuspid annular dilatation. First of all, tricuspid annular dilatation was made surgically in 8 mongrel dogs by placing 8 incisions to tricuspid annulus except septal cusp under the condition of heart-lung preparation. On clinical evaluation, septal annulus was kept to be intact in many cases compared with the two other areas. This experimental model of tricuspid annular dilatation was considered to be substituted to the clinical model of tricuspid annular dilatation. TAC suture was surrounded circumferentially around the dilated tricuspid annulus. And then, TAC suture was pulled out from the right atrial wall, and the circumferential length of tricuspid annulus was completely accommodated by pulling the TAC suture. The hemodynamic status was observed by right atrial pressure (V wave and mean) and right ventricular end-diastolic pressure (RVEDP). After heart resuscitation and gradual increase of preload, right atrial pressure was significantly elevated especially right atrial pressure (V wave) compared with control values. When 2 cm of circumferential length of tricuspid annulus on an average was constricted by shortening of TAC suture, right atrial pressure was significantly decreased, and then RVEDP tended to decrease. It was shown that TAC was an effective operative technique for the secondary tricuspid annular dilatation and tricuspid insufficiency from the standpoint of experimental aspect as well as clinical results. 相似文献
17.
K Matsuda Y Kiyota N Tamura M Takahashi H Miki H Suzuki Y Nakagawa Y Satou M Noda T Nakamura 《Kyobu geka. The Japanese journal of thoracic surgery》1990,43(5):389-391
A 64-year-old man, who had an aneurysm of aortic arch associated with the aberrant right subclavian artery, was treated successfully. He was pointed out to have an aneurysm of aortic arch three years ago. Three years later angiograms and computed tomography revealed that it became larger compared with the initial finding. He underwent a replacement of the aortic arch using a woven Dacron graft under open distal method. Aberrant subclavian artery was not involved in the aneurysm. But because the left subclavian artery was involved in it, a woven Dacron graft was interposed between the ascending aorta and left subclavian artery. Postoperative course was uneventful and there were no complications. 相似文献
18.
19.
E Kojima N Tamura Y Higashide B Lee T Yamaura H Ohnishi 《Nihon yakurigaku zasshi. Folia pharmacologica Japonica》1990,96(6):315-321
The effects of alminoprofen, a nonsteroidal anti-inflammatory agent, on the experimental animal models of allergic reactions were examined and compared with those of ibuprofen. Alminoprofen at 30 mg/kg given intraduodenally significantly suppressed passive anaphylactic bronchoconstrictions, while ibuprofen did not at the same doses. In vitro studies revealed that alminoprofen, in contrast to ibuprofen, exerted an inhibitory effect on arachidonate 5-lipoxygenase activity which initiates the bio-synthesis of leukotrienes. Alminoprofen inhibited arachidonic acid-induced ear edema in mice and homologous passive cutaneous anaphylaxis in rats at high doses, while ibuprofen did not at the high doses. From its characteristic feature of inhibitory effects on 5-lipoxygenase activity and the experimental model of type I allergic reaction, it is suggested that alminoprofen is a new type of nonsteroidal anti-inflammatory agent. 相似文献
20.
Shigeki Ohgitani Akimitsu Miyauchi Yasuyuki Takagi Yoshio Fujii Takuo Fujita Misa Nakamura Zhi-qiang Zhang Liang Shan Mitsuyo Sasaki Ryuichi Tsukino Toyoharu Yokoi Kennichi Kakudo Tomitaka Nakayama Junya Toguchida Hiroshi Kanoe Shinichi Aizawa Masao S. Sasaki Takashi Nakamura M. Suda K. Tanaka Y. Ogawa N. Tamura A. Yasoda H. Itoh M. Uehira N. Nishimoto T. Takigawa K. Shiota K. Nakao 《Journal of bone and mineral metabolism》1997,15(3):165-171