全文获取类型
收费全文 | 8173篇 |
免费 | 497篇 |
国内免费 | 43篇 |
专业分类
耳鼻咽喉 | 85篇 |
儿科学 | 198篇 |
妇产科学 | 249篇 |
基础医学 | 1199篇 |
口腔科学 | 206篇 |
临床医学 | 552篇 |
内科学 | 1943篇 |
皮肤病学 | 290篇 |
神经病学 | 654篇 |
特种医学 | 235篇 |
外科学 | 949篇 |
综合类 | 35篇 |
预防医学 | 334篇 |
眼科学 | 263篇 |
药学 | 575篇 |
中国医学 | 26篇 |
肿瘤学 | 920篇 |
出版年
2023年 | 52篇 |
2022年 | 130篇 |
2021年 | 200篇 |
2020年 | 113篇 |
2019年 | 206篇 |
2018年 | 209篇 |
2017年 | 156篇 |
2016年 | 197篇 |
2015年 | 200篇 |
2014年 | 279篇 |
2013年 | 337篇 |
2012年 | 569篇 |
2011年 | 600篇 |
2010年 | 328篇 |
2009年 | 289篇 |
2008年 | 479篇 |
2007年 | 535篇 |
2006年 | 549篇 |
2005年 | 554篇 |
2004年 | 506篇 |
2003年 | 444篇 |
2002年 | 443篇 |
2001年 | 105篇 |
2000年 | 82篇 |
1999年 | 91篇 |
1998年 | 98篇 |
1997年 | 79篇 |
1996年 | 64篇 |
1995年 | 53篇 |
1994年 | 54篇 |
1993年 | 38篇 |
1992年 | 70篇 |
1991年 | 64篇 |
1990年 | 49篇 |
1989年 | 57篇 |
1988年 | 61篇 |
1987年 | 58篇 |
1986年 | 40篇 |
1985年 | 41篇 |
1984年 | 46篇 |
1983年 | 31篇 |
1982年 | 12篇 |
1980年 | 9篇 |
1979年 | 20篇 |
1978年 | 14篇 |
1977年 | 9篇 |
1972年 | 9篇 |
1971年 | 8篇 |
1970年 | 8篇 |
1968年 | 10篇 |
排序方式: 共有8713条查询结果,搜索用时 15 毫秒
11.
12.
13.
M Nakamura E Koh N Kondoh M Takeyama M Namiki H Fujioka H Kiyohara Y Nishimune A Okuyama T Sonoda 《Archives of andrology》1990,24(1):69-72
The synthesis of DNA, RNA, and protein by varicocele testes with spermatogenic dysfunction was studied by examination of the levels of incorporation of [3H]thymidine, [14C]uridine, and [14C]leucine into the testicular tissue at 31 degrees C in vitro. The results suggest that DNA synthesis by the testis with moderate tubular damage is impaired whereas synthesis of RNA and protein is not. The cell regenerative ability of the testis with moderate tubular damage may be poor in spite of the preservation of testicular cell RNA and protein synthesis. 相似文献
14.
15.
Yukako Sato Masahiko Aoyama Tomoko Soeda Akihiko Hoshi Mari Honma Teiji Yamamoto 《Clinical neurology》2004,44(8):527-530
A 65-year-old woman with diabetes mellitus and chronic otitis media developed headache, fever, and hoarseness, all of which did not responded to the oral antibiotics. As stiff neck and lower cranial nerve palsies appeared, bacterial meningitis was suspected. Neurological examination revealed the right hearing disturbance, right recurrent laryngeal nerve palsy, left sternocleidomastoid muscle atrophy and bilateral tongue atrophy. The CSF examination revealed mild pleocytosis and elevated protein, but no bacterial organism was cultured from the CSF. CT scans showed bilateral mastoiditis, and the right mastoid process and a posterior part of the petrous bone were eroded, indicating the exposed bony structures to the posterior fossa. MRI scans demonstrated the thickening of the dura mater of the posterior fossa and the right cerebellar tentorium. This is a rare example of bacterial pachymeningitis of the posterior fossa, the clinical symptoms and MRI findings of which resolved solely by antimicrobial agents without corticosteroid. 相似文献
16.
Toyohiro Kagawa Fumiko Fukunari Tomoko Shiraishi Miwako Yamasaki Takahiro Ichihara Yuka Kihara Ryousuke Zeze Kentaro Nogami Kenji Yuasa 《Oral Radiology》2006,22(2):47-51
Objectives To develop a simple image viewer that utilizes image files in general-purpose formats that are written from the original 3DX
volume data.
Methods We used FLASH MX2004 for Macintosh to develop a simple image viewer. In developing the software for the simple image viewer,
we decided that the viewer should provide the following features: (1) be available to both Windows OS and Mac OS, (2) allow
interlocking of the 3D images, (3) display image enlargement, and (4) allow distance measurements. The accuracy of the distance
measurements was evaluated.
Results The procedure was as follows: (1) write 3D images in jpeg format to a folder on i-VIEW; (2) place the folder containing the
3D images into the directory of the simple image viewer software on a PC; (3) start the software and open the window to input
the folder name containing the 3D images; and (4) display the 3D images. Our viewer had features such as image enlargement,
interlocking 3D images, drawing, and distance measurements. No significant differences were shown between the measurements
made by our simple viewer and the actual values of the images in any direction.
Conclusions Our image-viewing software for 3DX is beneficial for clinical use. 相似文献
17.
Tomoko FUKUNAGA Satoshi UKAI Toshiko KOBAYASHI Tsuyoshi NISHIMURA Masatoshi TAKEDA 《Psychogeriatrics》2006,6(4):159-167
Background: Progression of the core and accessory symptoms of dementia can be slowed if drug therapies and psychosocial interventions are administered at an early stage. The aim of this study was to develop and standardize a neuropsychological test for the elderly that can detect dementia at an early stage with high sensitivity and can evaluate a wide range of severities of dementia based on assessments of various cognitive functions. Methods: A preliminary test consisting of 23 items and the Nishimura Mental State Scale for the Elderly (NM Scale), which evaluates the mental functions of elderly individuals by observing their actual behaviors in daily life, were administered to 448 elderly subjects. After applying Hayashi’s quantification theory type I to the results, we revised the preliminary test to construct a neuropsychological test for the elderly, which we named the Nishimura Dementia Test (ND Test), and standardized it. Then, we examined its validity and test–retest reliability. Results: Among the 448 subjects, there was a strong correlation between the ND Test scores and NM Scale scores. The ND Test showed a good general agreement rate for the discrimination of the severity of dementia, and good sensitivity and specificity of discrimination of dementia when compared with the actual NM Scale. Using different groups of elderly subjects, the ND Test showed validity and test–retest reliability, and the ND Test scores showed strong correlations with the Revised Hasegawa Dementia Scale scores and the Mini‐Mental State Examination scores. Conclusions: The ND Test is based on assessment of a variety of cognitive functions and can evaluate a wide range of severities of dementia with good validity and reliability. 相似文献
18.
Kiichiro Hashimoto Naohide Mori Takao Tamesa Toshimasa Okada Shigeto Kawauchi Atsunori Oga Tomoko Furuya Akira Tangoku Masaaki Oka Kohsuke Sasaki 《Modern pathology》2004,17(6):617-622
To clarify the genetic aberrations involved in the development and progression of hepatitis C virus-associated hepatocellular carcinoma (HCV-HCC), we investigated DNA copy number aberrations (DCNAs) in 19 surgically resected HCCs by conventional CGH and array CGH. Conventional CGH revealed that increases of DNA copy number were frequent at 1q (79% of the cases), 8q (37%), 6p (32%), and 10p (32%) and that decreases were frequent at 17p (79%), 16q (58%), 4q (53%), 13q (42%), 10q (37%), 1p (32%), and 8p (32%). In general, genes that showed DCNAs by array CGH were usually located in chromosomal regions with DCNAs detected by conventional CGH analysis. Increases in copy numbers of the LAMC2, TGFB2, and AKT3 genes (located on 1q) and decreases in copy numbers of FGR/SRC2 and CYLD (located on 1p and 16q, respectively) were observed in more than 30% of tumors, including small, well-differentiated carcinomas. These findings suggest that these genes are associated with the development of HCV-HCC. Increases of MOS, MYC, EXT1, and PTK2 (located on 8q) were detected exclusively in moderately and poorly differentiated tumors, suggesting that these alterations contribute to tumor progression. In conclusion, chromosomal and array CGH technologies allow identification of genes involved in the development and progression of HCV-HCC. 相似文献
19.
Nobutaka Eiraku Shinji Ijichi Shinji Yashiki Mitsuhiro Osame Shunro Sonoda 《Journal of neuroimmunology》1992,37(3):223-228
The in vitro proliferation of peripheral blood lymphocytes (PBLs) without any mitogenic stimulation is one of the hallmarks of human T lymphotropic virus type I (HTLV-I) infection. Recent evidence suggests a difference in the degree of the phenomenon between HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and asymptomatic HTLV-I carriers (AC). In this article, we demonstrated several alterations in the features of the in vitro transformed lymphocytes between patients with HAM/TSP (n = 16) and AC (n = 8). The percentages of total CD8+ and CD8+CD28+ cells were significantly increased in the in vitro proliferating T lymphocytes derived from the patients with HAM/TSP when compared to those from AC. HAM/TSP was segregated from AC by the high degree of the proliferation of CD8+CD28+ cells. The expression of HTLV-I-specific antigens on the cultured PBLs was detected only in the subjects which showed low CD8+CD28+/CD4+ ratio of the in vitro proliferating lymphocytes. These findings suggest that this phenomenon distinguishes HAM/TSP from AC, not only in quantity but also in quality. 相似文献
20.