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Gökçe Şimşek Sibel Alicura Tokgoz Erkan Vuralkan Murat Caliskan Omer Besalti Istemihan Akin 《European archives of oto-rhino-laryngology》2013,270(6):1789-1793
Cisplatin is a common chemotherapeutic agent used in many solid and hematologic malignancies. The main unwanted effect of cisplatin is ototoxicity, for which no standard treatment has been reported. The present study examined the protective efficacy of resveratrol on cisplatin-dependent ototoxicity through an experimental model. Fifteen rats were randomized into three groups. Group 1 (control group) (n = 5) received intraperitoneal (i.p.) 15 mg/kg cisplatin; group 2 (resveratrol group) (n = 5) received i.p. 100 mg/kg resveratrol, followed by i.p. 15 mg/kg cisplatin; group 3 (n = 5) served as a vehicle group and received i.p. 1 ml dimethyl sulfoxide. All rats underwent the auditory brainstem response (ABR) test before and 72 h after the treatment. Pretreatment ABR values of the groups were not significantly different. The pretreatment hearing threshold values of the groups were 30 ± 6.60 and 28.5 ± 5.29 dB in groups 1 and 2, respectively (p > 0.05). The post-ABR-I and post-ABR-IV values were, respectively, 1.41 ± 0.18 and 5.83 ± 0.16 ms in the control subjects and 1.19 ± 0.22 and 4.58 ± 0.27 ms in the study group. The ABR-I and ABR-IV durations in rats treated with resveratrol were significantly shorter (p < 0.01). A comparison of threshold values shows that the resveratrol-treated rats had significantly lower values than the control rats. After cisplatin injection, ABR I–IV intervals were compared among the groups. The ABR I–IV interval duration was 4.42 ± 0.16 ms in the control group, while the resveratrol-treated rats showed a significantly shorter ABR I–IV interval duration of 3.49 ± 0.27 ms (p < 0.001). Resveratrol attenuated cisplatin-dependent inner-ear damage, as shown by the ABR-I, ABR-IV, ABR I–IV interval, and hearing threshold values. Our results suggest that this natural antioxidant may be effectively used in reducing the unwanted effects of cisplatin on the ear physiology of patients, particularly those undergoing chemotherapy. 相似文献
34.
Nursen Oncel Acir Zeynep Dadaci Fatma Cetiner Murat Yildiz Husnu Alptekin Mehmet Borazan 《Cutaneous and ocular toxicology》2016,35(2):131-136
Objective: To evaluate the thickness of the peripapillary retinal fiber layer (RNFL) and macula ganglion cell-inner plexiform layer (GCL+) using optical coherence tomography (OCT) in patients with iron deficiency (ID) anemia.Methods: This study included 73 eyes of 39 patients with ID anemia and 68 eyes of 34 age- and sex-matched healthy subjects. The measurements included the peripapillary RNFL thicknesses as average, 4 quadrant and 12 clock-hour (CH) based and macula GCL+ thicknesses as average and 6 quadrant based. All measurements were completed with Cirrus HD-OCT and the results were compared between the groups.Results: A total of 73 eyes of 39 patients with ID anemia and 68 eyes of 34 healthy subjects were included to the study. Regarding peripapillary RNFL thicknesses of the study and control patients, the values of average and quadrants revealed no significant differences between the groups. In CH sectors comparison, peripapillary RNFL thicknesses were significantly decreased only in CH4 (68.7?±?14.5?μm in study versus 72.0?±?13.4?μm in control patients, p?=?0.049) and CH5 (93.4?±?20.0μm in study versus 102.2?±?20.1?μm in control patients, p?=?0.01) sectors. All measured quadrants were statistically similar, when macula GCL+ thicknesses were compared between the groups. When the correlations between peripapillary RNFL and macula GCL+ thicknesses and serum hemoglobin and ferritin levels of study and control patients were calculated, the only statistically significant parameter was the correlation of peripapillary RNFL thickness in CH10 sector with serum ferritin level (p?=?0.032, Spearman correlation coefficient: 0.369).Conclusion: The study revealed that peripapillary RNFL is thinner in nasal-inferior quadrant in patients with ID anemia. The measurements of macula GCL+ thicknesses were similar between the groups. Analyzing the retinal layers using OCT may provide valuable information in neurodegenerative events. 相似文献
35.
Zeynep Ozcan Husnu Celik Bilgin Gurates Hanifi Ibrahim Ozercan Fethi Hanay Mehmet Nalbant Zeynep Dogan 《Reproductive biomedicine online》2009,18(3):314-318
The aim of this study was to examine the effects of ovulation induction agents on the ovarian surface epithelium in rats. Sixty adult females were randomly divided into six groups, each containing 10 rats. In four of these groups ovulation induction was applied with six cycles of clomiphene citrate, human menopausal gonadotrophin (HMG), recombinant FSH (rFSH) or human chorionic gonadotrophin (HCG), respectively, followed by unilateral oophorectomy, and another six cycles of the same treatment. After a total of 12 cycles of ovulation induction, the remaining ovary was taken out and the alterations in ovarian surface epithelium were examined. No malignancies were observed on the ovarian surface epithelium of the rats that were given clomiphene citrate, rFSH or HMG as ovulation induction agents, while identification rates of histopathological parameters constituting epithelial dysplasia were found to be significant (P < 0.05). There was no significant dysplasia in the epithelium of the group which was given HCG only, relative to control groups. The findings suggest that the ovulation induction agents except for HCG bring about dysplasia in the ovarian surface epithelium. It is not clear whether these dysplasias are precursory lesions of ovarian malignancies. 相似文献
36.
Polat A Celik H Gurates B Kaya D Nalbant M Kavak E Hanay F 《Archives of gynecology and obstetrics》2009,279(4):527-532
Objective To determine the prevalence of primary dysmenorrhea and attitudes and behavior toward dysmenorrhea in the female students
of an university toward this problem.
Materials and methods A total of 1,266 female university students were anonymously surveyed by doctors.
Results It was found that mean age of the surveyed students was 21.02 ± 2.13 years, mean menarche age was 13.3 ± 1.4 years, and menstruation
frequency was 32.58 ± 19.8 days. Of the students, 45.3% were found to suffer pain in each menstruation, 42.5% in some and
12.2% in none. Of those with primary dysmenorrhea, 66.9% were established to take analgesic drugs.
Conclusion Prevalence of primary dysmenorrhea was found higher than that cited in the literature. It was established that although the
rate of consultation with health professionals about menstruation and related changes was low, use of agents known to be effective
in primary dysmenorrhea treatment was highly common. 相似文献
37.
Husnu Gorgen Murat Api Aysu Akça Ahmet Cetin 《Archives of gynecology and obstetrics》2009,279(6):835-840
Objective The aim of the present study was to measure the treatment of menorrhagia and health-related quality of life (QoL) in Levonorgestrel-releasing
intrauterine system (LNG-IUS) in Turkish women.
Materials and methods We recruited 66 premenopausal women, aged 26–55 years, who had sought care in the previous year for menorrhagia. All patients
were asked to complete a visual analog scale (VAS) form regarding pelvic pain, sexual life (libido) and general feeling of
health. Patients filled the VAS form before LNG-IUS insertion and after 6 months.
Results After the 6-month visit, PBAC score was condirebly decreased (p < 0.001). Six (10%) of the 60 patients PBAC score was higher than 75. VAS score for pelvic pain decreased from baseline to
6-month follow-up (4.32–3.55), and the libido and general feeling of health increased (4.27–4.95 and 3.47–6.87, respectively).
Conclusion The LNG-IUS device in the trearment of menorrhagia has cost effective, less side effects and increse in the QoL. 相似文献
38.
S. Tokgoz S. Cetinkunar C. Bilgin K. Bilgen Y. Ucar I. Colhan 《Acta chirurgica Belgica》2013,113(3):189-194
Background : To analyse the patient-related, disease-related and treatment-related factors in a group of melanoma patients to assess their impact on iliac metastasis and on overall survival.Methods : Medical records of thirty nine patients with lower extremity malignant melanoma were retrospectively reviewed to confirm all of the clinical data. Age and gender were recorded as patient-related factors. Tumor location, size, histology, ulceration status, and TNM stage, Breslow thickness, Clark level, presence of inguinal LN metastases, and locoregional metastases (local recurrences, in transit metastases and regional LN metastases) were evaluated as disease-related factors. Type of surgery (en block excision of primary tumor, en block excision of primary tumor and inguinal lymph node dissection, en block excision of primary tumor and ilioinguinal lymph node dissection) and postoperative chemotherapy were taken into account as treatment-related factors.Results : The presence of inguinal lymph node metastases was significantly associated with iliac metastasis (p = 0.015). Tumor size (p = 0.046), tumor TNM stage (p = 0.009), Breslow thickness (p = 0.033), Clark level (p = 0.029), presence of in transit metastases (p = 0.010) and postoperative chemotherapy (p = 0.002) has been related to impaired overall survival rate.Conclusions : Therapeutic lymph node dissection appears to carry a small but definite therapeutic benefit. Selection of appropriate patients for the more extensive procedure would be ideal, but at present there are no well proven selection criteria. The authors advocate therapeutic dissection when the inguinal lymph nodes are involved. 相似文献
39.
Davide Cattano Alfonso V. Altamirano Husnu E. Kaynak Carmen Seitan Rita Paniccia Zhongxue Chen Hanwen Huang Domenico Prisco Carin A. Hagberg Evan G. Pivalizza 《Journal of thrombosis and thrombolysis》2013,35(1):23-30
Five percent of patients on dual antiplatelet therapy after coronary artery stent implantation will need non-cardiac surgery within the first year of therapy, and many more will need surgery later on. A function assay that evaluates platelet reactivity and inhibition by drug therapy is beneficial for such patients. Platelet Mapping assay (PM?) using the TEG® analyzer was tested in surgical patients. After IRB approval, 60 patients on combined aspirin and clopidogrel therapy were consented and enrolled. The TEG® maximal amplitude (MA) and the percentage (%) platelet inhibition were recorded and analyzed. Fifty-seven patients (mean age 65.7 ± 10.9 years) had preoperative data only. Distribution of preoperative ADP (43.6 ± 24.4 %) and AA inhibition (52.8 ± 30.2 %) was determined, as well as for the preoperative MA ADP (43.1 ± 15.9 mm) and MA AA (37.2 ± 19.6 mm), showing an offset of the effect of both medications starting from day 3. Patients with complete pre- and postoperative data were stratified depending on duration off antiplatelet therapy (≤3 days, 3–7 days and >7 days): n = 27, ADP % preop inhibition (43.2 ± 21.6 %), ADP % postop inhibition (32.3 ± 18.3 %), p = 0.048. Distribution of immediate pre- and post- ADP and AA % inhibitions, showing a possible reduction in Δ of inhibition for clopidogrel at 3 days, were also assessed. Conclusion: According to the findings, the TEG® PM? assay might be a feasible approach to objectively evaluate the effects of aspirin and clopidogrel during the perioperative period and potentially guide drug management. 相似文献
40.
Zeliha Guzelkucuk Deniz Yılmaz Karapınar Sema Aylan Gelen Huseyin Tokgoz Alper Ozcan Yılmaz Ay Aysenur Bahadır Namik Yasar Ozbek Ayse Ceyda Oren Aylin Canbolat Ayhan Arzu Akyay Burcu Akıncı Nihal Karadas Aysegul Unuvar Hale Oren Ali Fettah Zuhre Kaya Bilgen Isık İbrahim Eker Serap Karaman Aysen Turedi Yıldırım Mehmet Fatih Orhan Yesim Oymak Cetin Timur Nalan Yazici Ayse Simsek Neslihan Karakurt Ersin Toret Melike Sezgin Evim 《Pediatric blood & cancer》2023,70(8):e30425