针刀干预对颈椎病兔软骨终板整合素β1-FAK力学信号通路的影响

目的观察针刀干预对颈椎病兔软骨终板整合素β1-FAK力学信号通路相关因子整合素β1、磷酸化黏着斑激酶(p-FAK)mRNA和蛋白表达的影响,探讨针刀在延缓椎间盘退变恢复颈椎力学平衡过程中的可能作用机制。方法将40只新西兰雄性兔随机分为空白组、模型组、电针组及针刀组,每组10只,空白组不做干预处理,其余建立颈椎病动物模型,持续12周。造模成功后电针组于兔颈肌两侧"天柱""颈百劳""大杼"穴处行毫针干预,隔天治疗1次,每周3次,共3周;针刀组于兔颈肌硬结、条索以及棘突等处行针刀干预,每周1次,共3次。干预结束后1周,采用实时荧光定量PCR法检测椎间盘软骨终板整合素β1、p-FAK的mRNA表达水平,采用Western Blot技术检测椎间盘软骨终板整合素β1、p-FAK的蛋白含量。结果与空白组相比,模型组软骨终板整合素β1 mRNA和蛋白表达水平均明显降低(P<0.01),软骨终板p-FAK蛋白表达水平升高(P<0.05)。与模型组相比,电针组软骨终板整合素β1、p-FAK蛋白表达水平均升高(P<0.05)。针刀组软骨终板整合素β1、p-FAK mRNA和蛋白表达水平均明显升高(P<0.01)。与电针组相比,针刀组软骨终板p-FAK mRNA和蛋白表达水平升高(P<0.05)。结论针刀干预可调节软骨终板整合素β1、p-FAK mRNA和蛋白表达,这可能是针刀减缓椎间盘退变,重建颈椎力学平衡,治疗颈椎病的作用机制之一。     

静脉血栓栓塞症护理管理干预实践与探讨

目的:规范院内静脉血栓栓塞症(VTE)的防治护理工作,为住院患者提供规范、同质的VTE护理.方法:建立院内VTE防治护理专项小组,完善VTE防治护理程序,构建VTE管理信息化平台,采用多种形式的VTE知识培训,进行VTE防治质量监控.结果:组建VTE防治护理专项小组后,VTE高危患者健康教育知晓率为84.2％,高于组建...     

Gingerol improves cardiac function in rats with cardiorenal syndrome via inhibiting fibrosis

Cardiorenal syndrome(CRS)is a clinical syndrome with a complex mechanism,and there is currently no specific treatment.Gingerol was confirmed to possess anti-inf...     

Negative bias effects during audiovisual emotional processing in major depression disorder

Aberrant affective neural processing and negative emotional bias are trait‐marks of major depression disorders (MDDs). However, most research on biased emotional perception in depression has only focused on unimodal experimental stimuli, the neural basis of potentially biased emotional processing of multimodal inputs remains unclear. Here, we addressed this issue by implementing an audiovisual emotional task during functional MRI scanning sessions with 37 patients with MDD and 37 gender‐, age‐ and education‐matched healthy controls. Participants were asked to distinguish laughing and crying sounds while being exposed to faces with different emotional valences as background. We combined general linear model and psychophysiological interaction analyses to identify abnormal local functional activity and integrative processes during audiovisual emotional processing in MDD patients. At the local neural level, MDD patients showed increased bias activity in the ventromedial prefrontal cortex (vmPFC) while listening to negative auditory stimuli and concurrently processing visual facial expressions, along with decreased dorsolateral prefrontal cortex (dlPFC) activity in both the positive and negative visual facial conditions. At the network level, MDD exhibited significantly decreased connectivity in areas involved in automatic emotional processes and voluntary control systems during perception of negative stimuli, including the vmPFC, dlPFC, insula, as well as the subcortical regions of posterior cingulate cortex and striatum. These findings support a multimodal emotion dysregulation hypothesis for MDD by demonstrating that negative bias effects may be facilitated by the excessive ventral bottom‐up negative emotional influences along with incapability in dorsal prefrontal top‐down control system.     

乌头汤治疗肾虚督寒型强直性脊柱炎30例临床观察

目的:观察乌头汤治疗肾虚督寒型强直性脊柱炎的临床疗效.方法:将60例活动期肾虚督寒型强直性脊柱炎患者随机分为治疗组和对照组,每组30例.治疗组口服乌头汤治疗,对照组口服美洛昔康片治疗.2组均以4周为1个疗程.观察2组ASAS20疗效、ASAS40疗效、中医证候疗效,以及治疗前后脊柱痛视觉模拟评分法(VAS)评分、患者自...     

手把手教初学者学习医学影像学论文写作

青年学者常常在完成资料收集和分析之后对获得的结果充满了激情。然而,在开始写作论文时,这种热情常常锐减。事实也如此,国家级学术会议的论文数远高于最终发表的医学文献数。优秀的研究成果不能发表的原因2大多在于写作新手在开始写作时对写作的认识混乱和畏缩。一般产生畏缩的原因有2个:要么是研究者不知从何着手,要么是不知如何组织文章结构。不过,大部分放射学论文的写作均有规律可寻,在很大程度上是程式化的。本文试图介绍一种可应用于典型放射学论文的逐段写作法。如果初学者能够完成按照本文教授的18段写作,其论文将具有合理的结构,…     

基于PEO模式的家庭作业治疗对卒中偏瘫患者功能预后的影响

目的 研究基于人-环境-作业（person-environment-occupation,PEO）模式的家庭作业治疗对卒中偏瘫患者上肢功能、日常生活活动能力及生活质量的影响。方法 前瞻性、连续纳入2020年1月—2020年12月南京市浦口人民医院（原南京市浦口区中心医院）康复医学科出院的卒中偏瘫患者,随机分为试验组和对照组,并分别建立微信群聊,对照组定期更新康复小视频,有任何问题随时咨询。试验组基于PEO模式,个性化更新每位患者的小视频,两组分别于出院时、出院3个月、6个月和12个月分别进行Fugl-Meyer运动功能量表上肢部分（Fugl-Meyer assessment upper extremity scale,FMA-UE）、日常生活活动能力Barthel指数（Barthel index,BI）及卒中专用生活质量量表（stroke-specific quality of life scale,SS-QOL）的评定。结果 最终纳入卒中偏瘫患者60例,平均年龄（63.10±6.83）岁,其中男性30例。将入组患者随机分为对照组和试验组各30例。组内比较显示,试验组出院3个月BI评分...     

血清胰岛素样生长因子-1、硫酸脱氢表雄酮、抗苗勒管激素及骨形态发生蛋白6在快进展型青春期女童中的早期预警价值

目的:研究血清胰岛素样生长因子-1(IGF-1)、硫酸脱氢表雄酮(DHEAS)、抗苗勒管激素(AMH)及骨形态发生蛋白6(BMP-6)水平对快进展型青春期(RPP)女童的早期预警价值。方法:回顾性分析2017年8月至2018年10月因乳房发育至苏州大学附属儿童医院内分泌遗传代谢科门诊就诊的750例女童的临床资料,随访6...     

Solvothermal synthesis of poly(acrylic acid) decorated magnetic molybdenum disulfide nanosheets for highly-efficient adsorption of cationic dyes from aqueous solutions

Herein we report solvothermal synthesis of poly(acrylic acid) (PAA) decorated magnetic molybdenum disulfide nanosheets (MMoS₂/PAA) for highly efficient adsorption of three cationic dyes of basic fuchsin (BF), methylene blue (MB), and crystal violet (CV) from aqueous solutions. The synthesized MMoS₂/PAA was characterized by several techniques including transmission electron microscopy (TEM), Fourier transform-infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), and dynamic light scattering (DLS). Due to the strong electrostatic interaction between cationic dyes and the anionic nanosheet surface, the obtained MMoS₂/PAA showed ultrafast adsorption of BF, MB and CV within 2 min with high adsorption capacities of 886.1, 709.0, and 633.6 mg g⁻¹, respectively, much higher than those materials reported recently. PAA molecules bound on the nanosheets played a crucial role in significantly enhancing the dye adsorption. The adsorption kinetics and isotherms of three dyes onto the MMoS₂/PAA were well described by the pseudo-second-order kinetic and the Langmuir models. Moreover, the MMoS₂/PAA also exhibited high removal efficiencies for various mixed-dye solutions. Besides, such a functional nanomaterial could be effectively recovered from dye solutions under an external magnetic field and reused for dye adsorption without compromising on its performance indicating it can serve as an excellent adsorbent for effective removal of a variety of cationic organic pollutants from industrial effluents.

Poly(acrylic acid) decorated magnetic MoS₂ nanosheets with high adsorption capacities for three cationic dyes have been successfully synthesized by a simple one-step solvothermal method.