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Early introduction of allergenic foods for the prevention of food allergy from an Asian perspective—An Asia Pacific Association of Pediatric Allergy,Respirology & Immunology (APAPARI) consensus statement 下载免费PDF全文
Elizabeth Huiwen Tham Lynette Pei‐Chi Shek Hugo PS Van Bever Pakit Vichyanond Motohiro Ebisawa Gary WK Wong Bee Wah Lee the Asia Pacific Association of Pediatric Allergy Respirology & Immunology 《Pediatric allergy and immunology》2018,29(1):18-27
Emerging evidence for the early introduction of allergenic foods for the prevention of food allergies, such as peanut allergy in Western populations, has led to the recent publication of guidelines in the USA and Europe recommending early peanut introduction for high‐risk infants with severe eczema or egg allergy. Peanut allergy is, however, much less prevalent in Asia compared to the West. Varying patterns of food allergy are seen even within Asian countries—such as a predominance of wheat allergy in Japan and Thailand and shellfish allergy in Singapore and the Philippines. Customs and traditions, such as diet and infant feeding practices, also differ between Asian populations. Hence, there are unique challenges in adapting guidelines on early allergenic food introduction to the Asian setting. In this paper, we review the evidence and discuss the possible approaches to guide the timely introduction of allergenic food in high‐risk infants in Asia. 相似文献
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Background
Statin can induce the gene expression of bone morphogenetic protein-2. Red yeast rice (RYR, Hongqu), i.e. rice fermented with Monascus purpureus, contains a natural form of statin. This study demonstrates the effects of RYR extract on bone formation.Methods
Bone defects were created in the parietal bones of two New Zealand white rabbits. In the test animal, two defects were grafted with collagen matrix mixed with RYR extract. In the control animal, two defects were grafted with collagen matrix alone. UMR 106 cell line was used to test RYR extract in vitro. In the control group, cells were cultured for three durations (24 hours, 48 hours and 72 hours) without any intervention. In the RYR group, cells were cultured for the same durations with various concentrations of RYR extract (0.001 g/ml, 0.005 g/ml and 0.01 g/ml). Bicinchoninic acid (BCA) assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and alkaline phosphatase (ALP) assay were performed to measure total protein, mitochondrial activity and bone cell formation respectively.Results
The test animal showed more formation of new bone in the defects than the control animal. RYR significantly increased the optical density in the MTT assay and ALP activity in vitro.Conclusion
RYR extract stimulated new bone formation in bone defects in vivo and increased bone cell formation in vitro. 相似文献26.
Michael WK. Fong Jacint Sala-Padro Melissa Bartley Mark AJ. Dexter Andrew F. Bleasel Chong H. Wong 《Epileptic Disord》2019,21(4):347-352
Aims. Small encephaloceles of the anterior temporal pole have been increasingly recognised as an underlying epileptogenic substrate in patients with medically refractory epilepsy. The current report aims to expand on the current knowledge by emphasising that seizure semiology in such patients can vary significantly. Methods. Patients were selected from an epilepsy surgery database between 2012 and 2017. Results. Of the 143 patients who underwent epilepsy surgery, six patients had a temporal encephalocele. Four of these patients had stereo-EEG implantation. Of the four patients studied, each had a seizure semiology discordant with an ictal focus in the temporal lobe. Intracranial EEG assessment demonstrated, irrespective of this semiology, seizures originated from the anterior temporal pole. Seizures were observed to rapidly propagate to the orbitofrontal cortex, insula, temporo-occipital junction, and posterior language regions. Engagement of the mesial temporal structures could occur early or late, however, a good surgical outcome was achieved following a focused lesionectomy in either situation. Conclusion. The major finding was that seizures arising from anterior temporal encephaloceles can have an extra-temporal semiology. The varied clinical semiology and the rapid propagation to seemingly distant cortical regions could be explained by the connectivity of the anterior temporal lobe. 相似文献
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目的探讨骨性Ⅲ类错手术与非手术边缘病例的颅面特征,为选择临床治疗方法提供参考。方法选择完成治疗的骨性Ⅲ类错边缘病例,单纯正畸组13例,手术治疗组12例,统计分析2组病例治疗前的X线头影测量值。结果Mann-Whitneyu检验显示2组下颌骨前颅底长度比Go-Me/S-N(P=0.026)、上下颌切牙的交角U1-L1(P=0.030)、Holdaway角(P=0.026)的差异有统计学意义,逐步判别分析后仅有Holdaway角能对2组进行预测区分,区分值为12°,总判别准确率为72%。结论制定骨性Ⅲ类错边缘病例治疗计划时,下颌骨前颅底长度比、上下颌切牙的交角以及软组织的凹陷度是要重点分析的颅面结构项目,小于12°的Holdaway角可以作为需手术改善软组织侧貌的初步判定指标。 相似文献
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