全文获取类型
收费全文 | 18714篇 |
免费 | 1513篇 |
国内免费 | 50篇 |
专业分类
耳鼻咽喉 | 129篇 |
儿科学 | 488篇 |
妇产科学 | 352篇 |
基础医学 | 2440篇 |
口腔科学 | 469篇 |
临床医学 | 1970篇 |
内科学 | 3698篇 |
皮肤病学 | 343篇 |
神经病学 | 1772篇 |
特种医学 | 740篇 |
外国民族医学 | 1篇 |
外科学 | 2524篇 |
综合类 | 230篇 |
一般理论 | 32篇 |
预防医学 | 2168篇 |
眼科学 | 369篇 |
药学 | 1267篇 |
中国医学 | 23篇 |
肿瘤学 | 1262篇 |
出版年
2023年 | 153篇 |
2022年 | 247篇 |
2021年 | 544篇 |
2020年 | 342篇 |
2019年 | 473篇 |
2018年 | 523篇 |
2017年 | 420篇 |
2016年 | 441篇 |
2015年 | 516篇 |
2014年 | 655篇 |
2013年 | 903篇 |
2012年 | 1407篇 |
2011年 | 1370篇 |
2010年 | 826篇 |
2009年 | 725篇 |
2008年 | 1172篇 |
2007年 | 1172篇 |
2006年 | 1130篇 |
2005年 | 1074篇 |
2004年 | 1035篇 |
2003年 | 948篇 |
2002年 | 810篇 |
2001年 | 313篇 |
2000年 | 270篇 |
1999年 | 241篇 |
1998年 | 197篇 |
1997年 | 146篇 |
1996年 | 116篇 |
1995年 | 109篇 |
1994年 | 89篇 |
1993年 | 92篇 |
1992年 | 152篇 |
1991年 | 129篇 |
1990年 | 119篇 |
1989年 | 118篇 |
1988年 | 93篇 |
1987年 | 103篇 |
1986年 | 111篇 |
1985年 | 77篇 |
1984年 | 75篇 |
1983年 | 82篇 |
1982年 | 63篇 |
1981年 | 40篇 |
1980年 | 40篇 |
1979年 | 52篇 |
1978年 | 51篇 |
1977年 | 36篇 |
1973年 | 46篇 |
1971年 | 42篇 |
1970年 | 36篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
82.
83.
Edward D. Levin Todd C. Brady Elizabeth Crapo Hochrein Tim D. Oury Lena M. Jonsson Stefan L. Marklund James D. Crapo 《Behavior genetics》1998,28(5):381-390
Extracellular superoxide dismutase (EC-SOD) controls the availability of extracellular superoxide (O
2
-
), which is important for a variety of physiological pathways, including the primary means of inactivating nitric oxide (NO). The role of EC-SOD in neurobehavioral function has been until now unexplored. In the current studies, the phenotypic expression of genotypic alterations of EC-SOD production in mice were characterized for spatial learning and memory. Dramatic impairments in spatial learning in the win-shift 8-arm radial maze were seen in both EC-SOD knockout mice and EC-SOD overexpressing mice. The EC-SOD overexpressing mice were further characterized as having significant deficits in a repeated acquisition task in the radial-arm maze, which permitted the dissociation of long and short-term learning. Long-term learning was significantly impaired by EC-SOD overexpression, whereas short-term learning was not significantly affected by EC-SOD overexpression. NO systems have been shown to be importantly involved in learning and memory. This may be important in the current studies because EC-SOD has primary control over the inactivation of NO. We found that EC-SOD overexpressing mice were resistant to the cognitive effects of L-NAME (NG-nitro-L-arginine methyl ester hydrochloride), an NO synthase inhibitor. Decreased NO catabolism in these mice may have served to counter the effects of NOS inhibition by L-NAME. The current finding that EC-SOD levels that were either higher or lower than controls impaired learning demonstrates that the proper control of brain extracellular (O
2
-
) may be more vital than merely reduction of brain extracelluar (O
2
-
) in maintaining adequate learning function. 相似文献
84.
High Rates of Clustering of Strains Causing Tuberculosis in Harare,Zimbabwe: a Molecular Epidemiological Study 下载免费PDF全文
85.
A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype 总被引:5,自引:0,他引:5
86.
87.
Tim Phetthong Thipwimol Tim‐Aroon Arthaporn Khongkrapan Preamrudee Poomthavorn Duangrurdee Wattanasirichaigoon 《American journal of medical genetics. Part A》2020,182(8):1873-1876
Kabuki syndrome (KS) is a rare heterogeneous phenotypic genetic syndrome, characterized by hypotonia, developmental delay and/or intellectual disability with typical facial features. It is challenging to diagnose KS in newborn and young infant. We report a Thai girl who presented with two rare co‐occurrence phenotypes, hyperinsulinemic hypoglycemia and midgut malrotation. She had not have distinctive facial dysmorphism during neonatal period. At 4 months of age, she had poor weight gain with some facial features suggestive KS. Singleton whole exome sequencing (WES) was carried out followed by Sanger sequencing of the supposed variant. The result indicated a novel de novo heterozygous KMT2D mutation, c.15364A>T (p.Lys5122*), confirming KS. Our patient revealed rare clinical manifestations from the diverse population and address the benefit of WES in establishing early diagnosis of KS before typical facial gestalt exhibited, which allows timely and appropriate management to maximize developmental achievement. 相似文献
88.
89.
This paper describes the outcomes of episodes of care for adults in public sector mental health services across Australia, with a view to informing the debate on service quality. Health of the Nation Outcome Scales (HoNOS) change scores and effect sizes were calculated for 14,659 acute inpatient episodes and 23,692 community episodes. The results showed that people in contact with public sector mental health services generally do get better, although the magnitude of improvement depends on the setting and episode type. This confirmatory finding is particularly positive, given current community concerns about the quality and effectiveness of mental health services. 相似文献
90.
Lazar A Gründemann D Berkels R Taubert D Zimmermann T Schömig E 《Journal of human genetics》2003,48(5):226-230
The extraneuronal monoamine transporter EMT (HGNC Nomenclature SLC22A3) is the molecular correlate of the classical uptake2 system responsible for the non-neuronal inactivation of circulating and centrally released catecholamines. Because of its
functional profile and expression pattern, EMT is regarded as a candidate gene for diseases related to the sympathetic nervous
system and neuropsychiatric disorders. We describe the first investigation of the genetic variability of the EMT gene in human.
Six single-nucleotide substitutions and one deletion were detected within the assumed core promoter, the exonic and flanking
intronic sequences and the 3'-untranslated region in 100 Caucasian individuals. No amino acid changes were found and Tajima's
D was positive (D=2.91; P<0.01). However, the synonymous nucleotide substitution 1233G→A might serve as a cryptic splice acceptor site. Analysis of
linkage disequilibrium between polymorphisms yielded 12 possible haplotypes accounting for more than 90% of all haplotypes.
Knowledge of the sequence variation and frequency of the underlying polymorphisms in this member of the amphiphilic solute
facilitator family of transporters provides the basis for subsequent association studies and candidate gene approaches.
Electronic Publication 相似文献