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81.
From July 1 994to June 1 999,5 4 5 onychomyco-sis patients were treated with Itraconazole and com-pleted their treatment courses with complete follow-up in out- patientdepartment.The recovery rate was83.1 4% and 79.2 3% in fingernail and toenail dis-eases respectively.But following phenomena werefound:( 1 ) Some new nails stopped growing in cer-tain length,even if the treatment continued;( 2 )Some damaged nails reappeared soon after the treat-ment ceased;( 3) Some damaged nails with deep- co… 相似文献
82.
用组织多普勒技术评价扩张型心肌病室壁运动 总被引:3,自引:0,他引:3
OBJECTIVE: To evaluate the characteristics of wall motion in cases of dilated cardiomyopathy (DCM) by the use of Doppler tissue imaging (DTI). METHODS: We observed 30 DCM patients and 30 normal volunteers. For the assessment of short axis motion, the myocardial velocities (MV) and transmural myocardial velocity gradients (MVG) of the middle segments of anterior interventricular septum and left ventricular posterior wall were recorded through parasternal long axis view. We detected the MV of the middle segments of left ventricular walls to evaluate the long axis motion through apical windows(4-chamber, 2-chamber and long axis). RESULTS: Four kinds of abnormal presentations of the waves were seen in DCM cases. The patients' MV of were obviously lower as compared with the controls', especially in long axis; the patients' MVG also decreased significantly (P < 0.05). In the patient group, the heterogeneity of wall motion disappeared too. CONCLUSION: PW-DTI can quantitatively assess the above abnormalities of DCM and provide supplementary information for clinical use. 相似文献
83.
目的 用组织多普勒技术分析扩张型心肌病 (DCM)室壁运动。方法 选择 DCM患者和正常对照各 30例 ,用组织多普勒技术于胸骨旁长轴检测室间隔及左室后壁中间段短轴方向心肌运动速度 (MV) ,并计算心肌运动速度阶差 (MVG) ;经心尖窗检测左室前、后、下、侧壁和前、后室间隔中间段长轴方向 MV。结果 DCM组患者有 4种 MV频谱异常表现 ,且 MV明显低于对照组 (P<0 .0 5 ) ,并以长轴为甚 ;MVG明显减低 (P<0 .0 5 ) ;室壁各种速度差异消失。结论 组织多普勒技术可定量反映 DCM患者室壁运动异常 相似文献
84.
运用原位杂交技术检测脂质体介导增殖细胞核抗原(PCNA)反义寡脱氧核苷酸抑制人膀胱癌细胞BIU-87PCNA mRNA的表达水平.结果表明脂质体介导PCNA反义寡脱氧核苷酸处理组中BIU-87细胞PCNA mRNA的表达水平明显低于对照组.结果提示脂质体介导PCNA反义寡脱氧核苷酸可抑制人膀胱癌细胞BIU-87体外增殖活性,其抑制作用可通过阻断PCNA蛋白表达来实现. 相似文献
85.
新时期病案信息在医院管理中的运用 总被引:10,自引:4,他引:6
病案不仅代表着一所医院的医疗技术水平,也反映着医院的管理经营能力。随着医疗机构体制改革的深入以及社会信息化的飞速发展,病案信息资源开发利用已成为病案管理部门主动为医院医疗、教学、科研、管理以及社会服务的重要手段。尤其是在即将实施的医疗保险制度中,更能体现其价值和作用。传统的病案信息管理以往大多局限于单一病案的收集、整理、登记和保管,而忽视了病案内涵信息的有效利用。在医疗卫生改革新形势下,病案管理人员要充分认识病案信息资源在医院管理和社会服务中的积极作用,才能在医疗市场经济中,变被动服务为主动服务。 相似文献
86.
Annals of Surgical Oncology - 相似文献
87.
Zhang Xuekai Zhou Kanggen Zeng Dewen Li Jia Wu Yehuizi Chen Wei Peng Changhong 《Bulletin of environmental contamination and toxicology》2022,109(1):86-94
Bulletin of Environmental Contamination and Toxicology - A novel process for the high-value-use of iron from bauxite residue was proposed in this work. The process was trying to use the... 相似文献
88.
89.
Rebecca L. Brocato Steven A. Kwilas Matthew D. Josleyn Simon Long Xiankun Zeng Casey C. Perley Lucia M. Principe Brandon Somerville Melanie V. Cohen Jay W. Hooper 《Vaccine》2021,39(7):1101-1110
DNA vaccine evaluation in small animals is hampered by low immunogenicity when the vaccines are delivered using a needle and syringe. To overcome this technical hurdle we tested the possibility that a device developed for human intradermal medicine delivery might be adapted to successfully deliver a DNA vaccine to small animals. Disposable syringe jet injection (DSJI) does not currently exist for small animals. However, a commercialized, human intradermal device used to to administer medicines to the human dermis in a 0.1 mL volume was evaluated in Syrian hamsters. Here, we found that hantavirus DNA vaccines administered to hamsters using DSJI were substantially more immunogenic than the same vaccines delivered by needle/syringe or particle mediated epidermal delivery (gene gun) vaccination. By adjusting how the device was used we could deliver vaccine to either subcutaneous tissues, or through the skin into the muscle. RNA and/or antigen expression was detected in epidermal, subepidermal and fibroblast cells. We directly compared six optimized and non-optimized hantavirus DNA vaccines in hamsters. Optimization, including codon-usage and mRNA stability, did not necessarily result in increased immunogenicity for all vaccines tested; however, optimization of the Andes virus (ANDV) DNA vaccine protected vaccinated hamsters from lethal disease. This is the first time active vaccination with an ANDV DNA vaccine has shown protective efficacy in the hamster model. The adaptation of a human intradermal jet injection device for use as a method of subcutaneous and intramuscular jet injection of DNA vaccines will advance the development of nucleic acid based medical countermeasures for diseases modeled in hamsters. 相似文献
90.
Yu Hongjuan Zeng Xueyun Sui Mingjie Liu Rui Tan Rachel Lee-Yin Yang Jinjin Huang Weidong Luo Nan 《Quality of life research》2021,30(3):855-866
Quality of Life Research - This study aimed to compare the measurement properties of EQ-5D-3L(3L) and EQ-5D-5L(5L) in patients with acute myeloid leukemia (AML) in China. We consecutively recruited... 相似文献