全文获取类型
收费全文 | 1891篇 |
免费 | 81篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 45篇 |
妇产科学 | 15篇 |
基础医学 | 219篇 |
口腔科学 | 28篇 |
临床医学 | 111篇 |
内科学 | 304篇 |
皮肤病学 | 18篇 |
神经病学 | 195篇 |
特种医学 | 53篇 |
外科学 | 304篇 |
综合类 | 7篇 |
预防医学 | 37篇 |
眼科学 | 89篇 |
药学 | 399篇 |
中国医学 | 3篇 |
肿瘤学 | 137篇 |
出版年
2023年 | 10篇 |
2022年 | 29篇 |
2021年 | 39篇 |
2020年 | 31篇 |
2019年 | 23篇 |
2018年 | 37篇 |
2017年 | 23篇 |
2016年 | 37篇 |
2015年 | 39篇 |
2014年 | 41篇 |
2013年 | 48篇 |
2012年 | 68篇 |
2011年 | 68篇 |
2010年 | 48篇 |
2009年 | 58篇 |
2008年 | 89篇 |
2007年 | 98篇 |
2006年 | 85篇 |
2005年 | 92篇 |
2004年 | 85篇 |
2003年 | 79篇 |
2002年 | 65篇 |
2001年 | 73篇 |
2000年 | 84篇 |
1999年 | 81篇 |
1998年 | 16篇 |
1997年 | 17篇 |
1996年 | 13篇 |
1995年 | 12篇 |
1994年 | 8篇 |
1993年 | 8篇 |
1992年 | 58篇 |
1991年 | 48篇 |
1990年 | 47篇 |
1989年 | 46篇 |
1988年 | 45篇 |
1987年 | 30篇 |
1986年 | 28篇 |
1985年 | 20篇 |
1984年 | 23篇 |
1983年 | 16篇 |
1982年 | 11篇 |
1980年 | 6篇 |
1979年 | 20篇 |
1978年 | 11篇 |
1977年 | 7篇 |
1974年 | 7篇 |
1971年 | 7篇 |
1970年 | 5篇 |
1969年 | 7篇 |
排序方式: 共有1978条查询结果,搜索用时 140 毫秒
71.
Makoto Hara Katsuiku Hirokawa Satoshi Kamei Toshiki Uchihara 《Acta neuropathologica》2013,125(4):565-579
Regional progression of neurofibrillary tangles (NFTs) around the hippocampus was traced on thick sections double immunofluorolabeled with RD3 and RD4 antibodies, specific for three- and four-repeat tau, respectively. As reported, the cubic density of all tau-positive neurons was predominant in the entorhinal cortex and cornu ammonis (CA)1, and decreased progressively to the CA2–4 subregions. Among the three isoform profiles (RD3+/4?, RD3+/4+, and RD3?/4+), this regional gradient was replicated with RD3+/4? and RD3+/4+ neurons, while RD3?/4+ neurons exhibited the reverse gradient. Comparison of the subregion pairs confirmed a consistent profile shift along this gradient in every case regardless of the abundance of NFTs. To clarify the underlying mechanism of this regional profile shift, intraneuronal intensity of RD3 and RD4 immunoreactivity (IR) was quantified. Although their intensities were both lower in dendrites than in the soma, this gradient was steeper with RD4, leaving RD3 IR in dendrites. Dendritic arborization was abundant in RD3?/4+ pretangles, attenuated in RD3+/4+ neurons, and further attenuated in RD3+/4? ghost tangles. These findings suggest that dendritic RD4 IR retracts first, leaving RD3 IR in the dendrites. Taken together, this dendrite-oriented retraction initiates the gradual shift from RD3?/4+ pretangle neurons to RD3+/4? ghost tangles by way of RD3+/4+ NFTs. This intraneuronal profile shift may be a basis for the regional gradation featured by the similar profile shift during progression of NFT pathology. 相似文献
72.
Hiroyuki Katano Kazuhiro Toriyama Yusuke Nishikawa Koichi Ito Akimichi Morita Yuzuru Kamei Kazuo Yamada 《Child's nervous system》2013,29(12):2295-2299
Background
In surgery of repair for spina bifida, various skin plastic techniques are sometimes necessary due to large skin defect or subsequent ulcers in cases when approximation on the midline is difficult.Case report
A baby was born with a large skin defect due to huge lumbar myeloschisis and kyphosis, which was repaired 2 days after birth using Limberg’s skin flap at the peak of kyphosis. Skin ischemia around the tip of the flap gradually enlarged and resulted in a large skin ulcer. We performed negative pressure wound therapy (NPWT) using a Vacuum Assisted Closure (V.A.C.®) therapy system for 4 weeks which shrank the ulcer remarkably. Subsequently, a pedicle skin flap without graft was performed to cover the rest of the ulcer, which adapted well without CSF leakage postoperatively.Conclusion
A combination treatment of NPWT and skin plastic surgery was successfully performed for a very young infant with spina bifida. NPWT could be another useful option for the treatment of ulcer following spina bifida repair surgery, though surgeons should carefully confirm that there is no CSF leakage before and during the procedure. 相似文献73.
Murakoshi Miki Kamei Koichi Ogura Masao Sato Mai Nada Taishi Suzuki Ryutaro Kamae Chikako Nishi Kentaro Kanamori Toru Nagano China Nozu Kandai Nakanishi Koichi Iijima Kazumoto 《Clinical and experimental nephrology》2022,26(2):162-169
Clinical and Experimental Nephrology - The management of congenital nephrotic syndrome of the Finnish type (CNF) is challenging. It is difficult to withdraw intravenous albumin infusions, resulting... 相似文献
74.
75.
Yohei Ozawa Takashi Kamei Toru Nakano Yusuke Taniyama Shigehito Miyagi Noriaki Ohuchi 《World journal of surgery》2016,40(7):1663-1671
Background
This study aimed to evaluate the recurrence rates, timings, locations, and risk factors, and survival in patients with lymph node-negative superficial esophageal squamous cell carcinomas (ESCCs).Methods
We investigated 167 patients with pathological T1 thoracic ESCC who underwent curative esophagectomy with lymphadenectomy between 1986 and 2013. They were classified into lymph node-negative and lymph node-positive groups, each of which included 15 relapsed patients. The recurrence rates, timings, locations, and risk factors, and survival were examined retrospectively.Results
Significantly better recurrence (12.4 %) and the 5-year overall survival (85.7 %) rates were seen in patients with node-negative superficial ESCC compared with those with node-positive superficial ESCC. Relapsed patients with node-negative superficial ESCC showed a 5-month delay in the time to recurrence compared with relapsed patients with node-positive superficial ESCC, but the recurrence locations were similar. Upper thoracic tumors and the presence of lymph node metastases were independent risk factors for recurrence in superficial ESCC patients, but we did not determine any risk factors in patients who were node negative only. The 5-year overall survival rates did not differ between relapsed node-negative and node-positive patients. Furthermore, the mean times to death and the survival rates from recurrence to death were similar in the node-negative (20.3 months and 9.3 %, respectively) and in the node-positive patients (19.1 months and 13.6 %, respectively) who had relapsed.Conclusions
Node-negative and node-positive superficial ESCC patients should be followed up similarly, because when recurrences occur, the prognoses and the times to death are similar in node-negative and node-positive superficial ESCC patients.76.
Summary. We screened in vitro antiviral activity against a salmonid pathogenic virus, infectious hematopoietic necrosis virus (IHNV), from the extracts
of a total of 342 species of marine algae collected from the Japanese coastline. The anti-IHNV activity was found primarily
in MeOH extracts, and the extract from one marine brown alga in particular, Eisenia bicyclis, showed high anti-IHNV activity. The anti-IHNV compound was isolated and purified as MC15 from the E. bicyclis extract, and the chemical structure was determined by several spectrometric analyses. The antiviral compound was proved to
be a chlorophyll c2 derivative lacking the metal ion Mg2+. MC15 showed similar antiviral activity against other salmonid enveloped viruses such as Paralichthys olivaceus virus and
Oncorhynchus masou virus, and stability against any pH and temperatures up to 100 °C. No cytotoxicity was observed at up to
5 μg/ml. The antiviral mechanism of MC15 appears to be direct inactivation of the viral particles. A time course study showed
that the inactivation of IHNV was completed within 40 min when 200 PFU of IHNV was reacted with MC15 at 800 ng/ml. 相似文献
77.
78.
79.
Morikawa Takanori Ishida Masaharu Takadate Tatsuyuki Hata Tatsuo Iseki Masahiro Kawaguchi Kei Ohtsuka Hideo Mizuma Masamichi Hayashi Hiroki Nakagawa Kei Motoi Fuyuhiko Kamei Takashi Naitoh Takeshi Unno Michiaki 《Surgery today》2020,50(2):153-162
Surgery Today - We introduced a superior approach and a unique technique to retract the stomach, called the “stomach roll-up technique”, to standardize laparoscopic distal... 相似文献
80.
Akira Ouchi Masatoshi Isogai Toru Harada Yuji Kaneoka Keitaro Kamei Atsuyuki Maeda 《Surgery today》2014,44(8):1552-1555
A 78-year-old male presented with the chief complaints of abdominal pain and vomiting. Contrast-enhanced computed tomography and abdominal angiography showed occlusion of the superior mesenteric artery due to thrombosis, and emergency percutaneous transluminal angioplasty and stent placement were carried out. Two months later, stent thrombosis developed, and a second stent was placed. Eight months later, he complained of general fatigue and anorexia. Gastrointestinal endoscopy revealed a duodenal ulcer at the third portion close to the superior mesenteric artery. Thirteen days after conservative management, duodenal ulcer penetration into the superior mesenteric artery with subsequent air embolism developed, and the patient died of multiple organ failure. 相似文献