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61.
Sushma Bhatnagar Saraswathi Devi NK Vinod PN Jain G Durgaprasad Sanjaykumar H Maroo Ketan R Patel 《Indian Journal of Palliative Care》2014,20(3):182-187
Aim:
To compare the efficacy and safety of oral transmucosal fentanyl citrate (OTFC) and oral morphine in Indian patients with breakthrough episodes of cancer pain.Materials and Methods:
In this randomized, open label, active controlled, clinical study, total 186 patients who regularly experienced 1-4 episodes of breakthrough cancer pain (BTCP) daily, over the persistent pain controlled by taking oral morphine 60 mg/day or its equivalent were randomized to receive either OTFC 200 mcg or oral morphine 10 mg for the treatment of BTCP for 3 days. Improvement in pain as determined by numerical rating scale (NRS) at 5, 15, 30, and 60 minutes of drug administration and percentage of BTCP episodes showing reduction in pain intensity by >33% at 15 minutes were primary efficacy endpoints. Secondary efficacy endpoints were requirement for rescue analgesia and global assessment by physician and patient. Data of both treatment groups were analysed by appropriate statistical test using software, STATISTICA, version 11.Results:
Patients treated with OTFC experienced significantly greater improvement in pain intensity of breakthrough episodes compared to those treated with oral morphine at all assessment time points (P < 0.0001). 56% of breakthrough pain episodes treated with OTFC showed a greater than 33% reduction in pain intensity from baseline at 15 minutes compared to 39% episodes treated with oral morphine (P < 0.0001). Patient''s and physician''s global assessment favoured OTFC than oral morphine (P < 0.0001). Requirement of rescue analgesia in both the study groups was similar (P > 0.05). Both study drugs were well tolerated.Conclusions:
OTFC was found to provide faster onset of analgesic effect than immediate release oral morphine in management of breakthrough cancer pain. 相似文献62.
63.
Arieska Ann Soenarta Peera Buranakitjaroen Yook‐Chin Chia Chen‐Huan Chen Jennifer Nailes Satoshi Hoshide Huynh Van Minh Sungha Park Jinho Shin Saulat Siddique Jorge Sison Guru Prasad Sogunuru Apichard Sukonthasarn Jam Chin Tay Boon Wee Teo Yuda Turana Narsingh Verma Tzung‐Dau Wang Yu‐Qing Zhang Ji‐Guang Wang Kazuomi Kario 《Journal of clinical hypertension (Greenwich, Conn.)》2020,22(3):423-430
Cardiovascular Disease (CVD) is the leading cause of deaths worldwide, contributing to about 30% of all deaths. Half of the cases of CVD are estimated in Asia, the world's most populous continent. Hypertension, a major modifiable risk factor for CVD, results in more deaths than any other CV risk factors in the Asian regions. The total number of patients with hypertension is likely to grow as the population ages. The proportion of the elderly population aged 65 years or more in Asia is expected to increase from 7.4% in 2015 to 10.9% in 2030. It is important to note that more than half (54%) of the world's population live in Asia. Aside of being the biggest single risk factor for global deaths, hypertension is also an important precursor and most common risk factor of heart failure (HF). An increase in HF prevalence is clearly related to the rapid epidemiological transition caused by changes in lifestyle in Asian countries. However, the availability of data on HF burden and health care delivery is limited in Asia compared with Europe and North America. This reality has driven the working group of Asian experts for example the HOPE Asia Network to concentrate on hypertension as risk factors for CVD, with the mission to improve the management of hypertension resulting in organ protection toward a goal of achieving “ZERO” CV event in Asia. This paper aims to give an overview regarding the heart problems caused by hypertension in Asia, focus on HF. 相似文献
64.
Jinho Shin Kazuomi Kario Yook‐Chin Chia Yuda Turana Chen‐Huan Chen Peera Buranakitjaroen Romeo Divinagracia Jennifer Nailes Satoshi Hoshide Saulat Siddique Jorge Sison Arieska Ann Soenarta Guru Prasad Sogunuru Jam Chin Tay Boon Wee Teo Yu‐Qing Zhang Sungha Park Huynh Van Minh Tomoyuki Kabutoya Narsingh Verma Tzung‐Dau Wang Ji‐Guang Wang 《Journal of clinical hypertension (Greenwich, Conn.)》2020,22(3):384-390
Ambulatory blood pressure monitoring (ABPM) can measure 24‐hour blood pressure (BP), including nocturnal BP and diurnal variations. This feature of ABPM could be of value in Asian populations for preventing cardiovascular events. However, no study has yet investigated regarding the use of ABPM in actual clinical settings in Asian countries/regions. In this study, 11 experts from 11 countries/regions were asked to answer questionnaires regarding the use of ABPM. We found that its use was very limited in primary care settings and almost exclusively available in referral settings. The indications of ABPM in actual clinical settings were largely similar to those of home BP monitoring (HBPM), that is, diagnosis of white‐coat or masked hypertension and more accurate BP measurement for borderline clinic BP. Other interesting indications, such as nighttime BP patterns, including non‐dipper BP, morning BP surge, and BP variability, were hardly adopted in daily clinical practice. The use of ABPM as treatment guidance for detecting treated but uncontrolled hypertension in the Asian countries/regions didn't seem to be common. The barrier to the use of ABPM was primarily its availability; in referral centers, patient reluctance owing to discomfort or sleep disturbance was the most frequent barrier. ABPM use was significantly more economical when it was reimbursed by public insurance. To facilitate ABPM use, more simplified indications and protocols to minimize discomfort should be sought. For the time being, HBPM could be a reasonable alternative. 相似文献
65.
Kazuomi Kario Yook‐Chin Chia Apichard Sukonthasarn Yuda Turana Jinho Shin Chen‐Huan Chen Peera Buranakitjaroen Jennifer Nailes Satoshi Hoshide Saulat Siddique Jorge Sison Arieska Ann Soenarta Guru Prasad Sogunuru Jam Chin Tay Boon Wee Teo Yu‐Qing Zhang Sungha Park Huynh Van Minh Naoko Tomitani Tomoyuki Kabutoya Narsingh Verma Tzung‐Dau Wang Ji‐Guang Wang 《Journal of clinical hypertension (Greenwich, Conn.)》2020,22(3):331-343
The Hypertension Cardiovascular Outcome Prevention and Evidence in Asia (HOPE Asia) Network was set up to improve the management of hypertension in Asia with the ultimate goal of achieving “zero” cardiovascular events. Asia is a diverse continent, and the prevalence of hypertension has increased over the last 30 years. There are a number of Asia‐specific features of hypertension and hypertension‐related cardiovascular complications, which means that a region‐specific approach is needed. White‐coat hypertension will become more of an issue over time as Asian populations age, and masked hypertension is more prevalent in Asian than in Western countries. Identifying and treating masked hypertension is important to reduce cardiovascular risk. Abnormal patterns of blood pressure (BP) variability common in Asia include exaggerated early morning BP surge and nocturnal hypertension. These are also important cardiovascular risk factors that need to be managed. Home blood pressure monitoring (HBPM) is an important tool for detecting white‐coat and masked hypertension, and monitoring BP variability, and practices in Asia are variable. Use of HBPM is important given the Asia‐specific features of hypertension, and strategies are needed to improve and standardize HBPM usage. Development of HBPM devices capable of measuring nocturnal BP along with other information and communication technology‐based strategies are key developments in the widespread implementation of anticipation medicine strategies to detect and prevent cardiovascular events in patients with hypertension. Region‐wide differences in hypertension prevalence, control, and management practices in Asia highlight the importance of information sharing to facilitate best practices. 相似文献
66.
Bellot GL Tan WH Tay LL Koh D Wang X 《Journal of cancer research and clinical oncology》2012,138(3):463-482
Purpose
Since primary tumor cells from patients have been used as a model for assessment of drug response for individual patients, this study aims to evaluate the reliability of such a model in colorectal cancer (CRC) in predicting the response of tumor tissues through comparison of their expression profiles. 相似文献67.
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70.
Wan-chun Zhu Jacqueline Gyamfi Li-na Niu G. John Schoeffel Si-ying Liu Filippo Santarcangelo Sara Khan Kelvin C.-Y. Tay David H. Pashley Franklin R. Tay 《Journal of dentistry》2013