全文获取类型
收费全文 | 181篇 |
免费 | 22篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 17篇 |
妇产科学 | 1篇 |
基础医学 | 52篇 |
口腔科学 | 5篇 |
临床医学 | 14篇 |
内科学 | 25篇 |
皮肤病学 | 4篇 |
神经病学 | 7篇 |
特种医学 | 12篇 |
外科学 | 6篇 |
综合类 | 8篇 |
预防医学 | 10篇 |
眼科学 | 1篇 |
药学 | 3篇 |
肿瘤学 | 39篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 3篇 |
2020年 | 4篇 |
2019年 | 5篇 |
2018年 | 5篇 |
2017年 | 5篇 |
2016年 | 4篇 |
2015年 | 3篇 |
2014年 | 4篇 |
2013年 | 14篇 |
2012年 | 9篇 |
2011年 | 6篇 |
2010年 | 10篇 |
2009年 | 8篇 |
2008年 | 14篇 |
2007年 | 7篇 |
2006年 | 13篇 |
2005年 | 6篇 |
2004年 | 2篇 |
2003年 | 4篇 |
2002年 | 4篇 |
2001年 | 3篇 |
2000年 | 4篇 |
1999年 | 8篇 |
1998年 | 5篇 |
1997年 | 7篇 |
1996年 | 1篇 |
1995年 | 3篇 |
1993年 | 6篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 4篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1975年 | 1篇 |
1970年 | 1篇 |
1966年 | 1篇 |
1954年 | 1篇 |
1952年 | 1篇 |
1940年 | 1篇 |
排序方式: 共有204条查询结果,搜索用时 15 毫秒
61.
S Singh SV Gibikote S Sen A Korula IP Korah 《Journal of Medical Imaging and Radiation Oncology》1999,43(4):539-541
A case of hydatid disease of the lung proven by thoracotomy and histopathological evaluation is described. It was clinically and radiologically suggestive of a complicated pulmonary sequestration or non-resolving consolidation. 相似文献
62.
The present study has analysed the DNA adducts formed in SENCAR mouse
epidermis following topical application of 7-methylbenz[a]anthracene (7-
MBA). Mice were treated with 400 nmol of 7-MBA, which represents an
initiating dose of this hydrocarbon for SENCAR mice. DNA adducts were
analysed 24 h after topical application of the hydrocarbon by 32P-
postlabeling coupled with either HPLC analysis or an improved TLC procedure
giving better resolution of DNA adducts through the use of a D6 solvent
[isopropanol:4N NH4OH (1:1)] following D5. Twenty-four hours after topical
application of 400 nmol 7-MBA, the level of total covalent binding was 0.37
+/- 0.07 pmol/mg DNA as determined by 32P- postlabeling. This level of
binding correlated well with the relative tumor initiating activity of this
hydrocarbon compared to 7,12- dimethylbenz[a]anthracene (6.4 +/- 0.01
pmol/mg DNA) and dibenz[a,j]anthracene (0.03 +/- 0.01 pmol/mg DNA).
Analysis of the 32P- labeled 3',5'-diphosphodeoxyribonucleosides by HPLC
and TLC revealed the presence of deoxyguanosine (dGuo) and deoxyadenosine
(dAdo) adducts formed from both the anti- and syn-bay-region diol-epoxides
of 7-MBA (anti- and syn-7-MBADEs). The major DNA adduct derived from 7-MBA
in mouse epidermis was tentatively identified as (+) anti-7-MBADE-trans-N2-
dGuo. In addition, a minor dGuo adduct derived from the bay-region syn-
diol-epoxide of 7-MBA was detected as well as a minor dAdo adduct from this
diol-epoxide. Another minor dAdo adduct was also detectably present which
arose from either the anti- or syn-diol epoxide. Furthermore, several
unidentified DNA adducts were present in both HPLC and TLC chromatograms of
DNA samples from 7-MBA-treated mice. These results are discussed in terms
of the role of specific 7-MBA-DNA adducts in tumor initiation by this
hydrocarbon.
相似文献
63.
64.
Intercalary bone allografts: radiographic evaluation 总被引:2,自引:0,他引:2
65.
Giant cell tumor of bone: radiographic changes following local excision and allograft replacement 总被引:1,自引:0,他引:1
The authors retrospectively evaluated the clinical records and radiographs obtained from 41 patients who had giant cell tumor of bone and who were treated by local resection and allograft replacement. Postoperative complications developed in 41% of the patients. However, the eventual clinical outcome was considered to be satisfactory in 85% of all cases. There were no instances of tumor recurrence, and surprisingly, postoperative arthritis was not a major problem. The major complications encountered were infection and allograft fracture; bone infection accounted for most of the clinical failures. All infections were associated with the increasing soft-tissue swelling and bone resorption detected on radiographic studies. Other radiographic parameters that were associated with an increased rate of complications included osteopenia, increased periosteal reaction, and decreased bone formation at the host-donor junction site. The clinical outcome was distinctly less favorable in those cases in which the patient had had a pathologic fracture or a previous resection, or in whom the graft was implanted at the distal radius. 相似文献
66.
Avard D Bridge P Bucci LM Chiquette J Dorval M Durocher F Easton D Godard B Goldgar D Knoppers BM Laframboise R Lespérance B Plante M Tavtigian SV Vézina H Wilson B;INHERIT BRCAs Simard J 《Familial cancer》2006,5(1):3-13
Today it is common to conduct research in collaboration with colleagues from different disciplines and institutions. The INterdisciplinary
HEalth Research International Team on BReast CAncer susceptibility (INHERIT BRCAs), involves Canadian and international experts
from diverse fields working with health service providers, patients and collaborators from the World Health Organization and
other European networks. Evidence-based information and knowledge transfer drive our efforts to advance genomic research to
understand the genetic basis of cancer susceptibility and treatment response. Several goals reveal the interdisciplinary team
approach: (a) to estimate the prevalence and penetrance of BRCA1 and BRCA2 mutations and their deleterious impact upon different populations; (b) to pinpoint novel breast cancer susceptibility loci;
(c) to assess the efficacy of clinical interventions; (d) to address changes in quality of life and health-related behaviour
from the decision to undergo genetics testing and during follow-up; (e) to evaluate legal, social and ethical implications;
and, finally; (f) to promote professional and public education by facilitating the transfer of research findings to clinical
practice and informing policy makers. The lessons learned by the INHERIT research team and future challenges are presented.
* The Interdisciplinary Health Research International Team on Breast Cancer Susceptibility (INHERIT BRCAs) is an international
team of researchers with a major interest in inherited breast cancer. The team is funded by the Canadian Institutes of Health
Research. Other members and collaborators of INHERIT BRCAs involved in this study are listed in Appendix A. 相似文献
67.
Farrugia DJ Agarwal MK Pankratz VS Deffenbaugh AM Pruss D Frye C Wadum L Johnson K Mentlick J Tavtigian SV Goldgar DE Couch FJ 《Cancer research》2008,68(9):3523-3531
The assessment of the influence of many rare BRCA2 missense mutations on cancer risk has proved difficult. A multifactorial likelihood model that predicts the odds of cancer causality for missense variants is effective, but is limited by the availability of family data. As an alternative, we developed functional assays that measure the influence of missense mutations on the ability of BRCA2 to repair DNA damage by homologous recombination and to control centriole amplification. We evaluated 22 missense mutations from the BRCA2 DNA binding domain (DBD) that were identified in multiple breast cancer families using these assays and compared the results with those from the likelihood model. Thirteen variants inactivated BRCA2 function in at least one assay; two others truncated BRCA2 by aberrant splicing; and seven had no effect on BRCA2 function. Of 10 variants with odds in favor of causality in the likelihood model of 50:1 or more and a posterior probability of pathogenicity of 0.99, eight inactivated BRCA2 function and the other two caused splicing defects. Four variants and four controls displaying odds in favor of neutrality of 50:1 and posterior probabilities of pathogenicity of at least 1 x 10(-3) had no effect on function in either assay. The strong correlation between the functional assays and likelihood model data suggests that these functional assays are an excellent method for identifying inactivating missense mutations in the BRCA2 DBD and that the assays may be a useful addition to models that predict the likelihood of cancer in carriers of missense mutations. 相似文献
68.
Hartimath SV Draghiciu O. Daemen T Nijman H.W. van Waarde A. Dierckx R.A.J.O. de Vries E.F.J. 《Molecular imaging and biology》2020,22(4):883-890
Molecular Imaging and Biology - Chemokine CXCL12 and its receptor CXCR4 are constitutively overexpressed in human cancers. The CXCL12-CXCR4 signaling axis plays an important role in tumor... 相似文献
69.
Sean V. Tavtigian Steven M. Harrison Kenneth M. Boucher Leslie G. Biesecker 《Human mutation》2020,41(10):1734-1737
Recently, we demonstrated that the qualitative American College of Medical Genetics and Genomics/Association for Medical Pathology (ACMG/AMP) guidelines for evaluation of Mendelian disease gene variants are fundamentally compatible with a quantitative Bayesian formulation. Here, we show that the underlying ACMG/AMP “strength of evidence categories” can be abstracted into a point system. These points are proportional to Log(odds), are additive, and produce a system that recapitulates the Bayesian formulation of the ACMG/AMP guidelines. The strengths of this system are its simplicity and that the connection between point values and odds of pathogenicity allows empirical calibration of the strength of evidence for individual data types. Weaknesses include that a narrow range of prior probabilities is locked in and that the Bayesian nature of the system is inapparent. We conclude that a points‐based system has the practical attribute of user‐friendliness and can be useful so long as the underlying Bayesian principles are acknowledged. 相似文献
70.