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61.
Hideyuki Arima Yu Yamato Kimihito Sato Yoshihiro Uchida Toshiyuki Tsuruta Kanehisa Hashiguchi Hajime Hamamoto Eiichiro Watanabe Kaoru Yamanaka Tomohiko Hasegawa Go Yoshida Tatsuya Yasuda Tomohiro Banno Shin Oe Hiroki Ushirozako Tomohiro Yamada Koichiro Ide Yuh Watanabe Yukihiro Matsuyama 《Journal of orthopaedic science》2021,26(4):577-583
BackgroundSagittal spino-pelvic malalignment in patients with chronic low back pain (CLBP) have been reported in the past, which may also affect cervical spine lesions. The purpose of this study is to investigate the cervical alignment in patients with CLBP.MethodOf the patients who visited an orthopedic specialist due to low back pain lasting more than three months, 121 cases (average 71.5-years-old, 46 male and 75 female) with whole standing spinal screening radiographs were reviewed (CLBP group). Cervical parameters included cervical lordosis (CL), C2–C7 sagittal vertical axis (C2-7 SVA), and the T1 slope minus CL (T1S-CL). Cervical spine deformity was defined as C2-7 SVA >4 cm, CL <0°, or T1S-CL ≧20°. We compared the cervical alignment of these patients with 121 age and gender matched volunteers (control group).ResultsThe prevalence of cervical spine deformity was significantly higher in the CLBP group than in the control group (20.7% vs. 10.7%, P = 0.034). The mean CL was smaller in the CLBP group than in the control group (16.1° vs. 21.4°, P = 0.002). The mean C2-7 SVA was 17.6 mm vs. 18.7 mm in the CLBP group and in the control group, respectively (P = 0.817). The mean T1S-CL was larger in the CLBP group than in the control group (9.1° vs. 3.5°, P < 0.001). Multivariate analysis showed that people with CLBP were more likely to have cervical deformities than people without CLBP (odds ratio 2.16, 95% confidence interval 1.006 to 4.637).ConclusionsThis study results suggest that people with CLBP present with worse cervical sagittal alignment and higher prevalence of cervical spine deformities than age and gender matched volunteers with no CLBP. This means CLBP impacts cervical spine lesions negatively.Level of evidenceⅣ 相似文献
62.
Yosuke Tsuruga Toshiya Kamiyama Hirofumi Kamachi Tatsuya Orimo Shingo Shimada Akihisa Nagatsu Yoh Asahi Yuzuru Sakamoto Tatsuhiko Kakisaka Akinobu Taketomi 《World journal of gastrointestinal surgery》2021,13(2):153-163
BACKGROUNDPreoperative portal vein embolization (PVE) is a widely used strategy to enable major hepatectomy in patients with insufficient liver remnant. PVE induces hypertrophy of the future liver remnant (FLR) and a shift of the functional reserve to the FLR. However, whether the increase of the FLR volume (FLRV) corresponds to the functional transition after PVE remains unclear.AIMTo investigate the sequential relationship between the increase in FLRV and functional transition after preoperative PVE using 3-dimensional (3D) computed tomography (CT) and 99mTc-galactosyl-human serum albumin (99mTc-GSA) single-photon emission computed tomography (SPECT) fusion images. METHODSThirty-three patients who underwent major hepatectomy following PVE at the Department of Gastroenterological Surgery I, Hokkaido University Hospital between October 2013 and March 2018 were enrolled. Three-phase dynamic multidetector CT and 99mTc-GSA SPECT scintigraphy were performed at pre-PVE, and at 1 and 2 wk after PVE; 3D 99mTc-GSA SPECT CT-fused images were constructed from the Digital Imaging and Communications in Medicine data using 3D image analysis system. Functional FLRV (FFLRV) was defined as the total liver volume × (FLR volume counts/total liver volume counts) on the 3D 99mTc-GSA SPECT CT-fused images. The calculated FFLRV was compared with FLRV.RESULTSFFLRV increased by a significantly larger extent than FLRV at 1 and 2 wk after PVE (P < 0.01). The increase in FFLRV and FLRV was 55.1% ± 41.6% and 26.7% ± 17.8% (P < 0.001), respectively, at 1 wk after PVE, and 64.2% ± 33.3% and 36.8% ± 18.9% (P < 0.001), respectively, at 2 wk after PVE. In 3 of the 33 patients, FFLRV levels decreased below FLRV at 2 wk. One of the three patients showed rapidly progressive fatty changes in FLR. The biopsy at 4 wk after PVE showed macro- and micro-vesicular steatosis of more than 40%, which improved to 10%. Radical resection was performed at 13 wk after PVE. The patient recovered uneventfully without any symptoms of pos-toperative liver failure.CONCLUSIONThe functional transition lagged behind the increase in FLRV after PVE in some cases. Evaluating both volume and function is needed to determine the optimal timing of hepatectomy after PVE. 相似文献
63.
Yuko Kaneyasu Hisaya Fujiwara Tetsuo Nishimura Hideyuki Sakurai Tomoko Kazumoto Hitoshi Ikushima Takashi Uno Sunao Tokumaru Yoko Harima Hiromichi Gomi Takafumi Toita Midori Kita Shin-ei Noda Takeo Takahashi Shingo Kato Ayako Ohkawa Akiko Tozawa-Ono Hiroki Ushijima Yoko Hasumi Yasuyuki Hirashima Yuzuru Niibe Tomio Nakagawa Tomoyuki Akita Junko Tanaka Tatsuya Ohno the Working Group of the Gynecological Tumor Committee of the Japanese Radiation Oncology Study Group 《Journal of radiation research》2021,62(2):269
This study aimed to research the post-treatment quality of life (QOL) between radiotherapy (RT)- and operation (OP)-treated early cervical cancer survivors, using separate questionnaires for physicians and patients. We administered an observational questionnaire to patients aged 20–70 years old with Stages IB1–IIB cervical cancer who had undergone RT or OP and without recurrence as outpatients for ≥6 months after treatment. We divided 100 registered patients equally into two treatment groups (n = 50 each). The average age was 53 and 44 years in the RT and OP groups, respectively. The RT group included 34 and 66% Stage I and II patients, respectively, whereas the OP group included 66 and 34% Stage I and II patients, respectively. The OP group included 58% of patients with postoperative RT. Combination chemotherapy was performed in 84 and 48% of patients in the RT and OP groups, respectively. On the physicians’ questionnaire, we observed significant differences in bone marrow suppression (RT) and leg edema (OP). On the patients’ questionnaire, significantly more patients had dysuria and leg edema in the OP group than in the RT group, and severe (Score 4–5) leg edema was significantly higher in the post-operative RT group than in the OP only group. The frequency of sexual intercourse decreased after treatment in both groups. On the patients’ questionnaire, there were no significant differences between the two groups regarding sexual activity. These findings are useful to patients and physicians for shared decision-making in treatment choices. The guidance of everyday life and health information including sexual life after treatment is important. 相似文献
64.
Yokota K Johyama Y Yamaguchi K Fujikt Y Takeshita T Morimoto K 《Environmental health and preventive medicine》1996,1(3):133-135
Methylterahydrophthalic anhydride (MTHPA) is used as a hardening agent in an epoxy resin system. Because work-related nasal symptoms were observed in some workers exposed toMTHPA at two condenser plants, a cross-sectional survey was performed to improve their work environment. MeanMTHPA levels in the manufacturing processes to which the workers were routinely assigned were extremely low (1.09-22.4 μg/m3). However, specific IgE antibody (S-IgE) was detected in 9 (32%) of 28 workers. Of these, 8 (89%) had nasal symptoms. An IgE-mediated mechanism seems to be associated with at least some of the cases of work-related nasal symptoms. This indicates that the occupational health administration ofMTHPA cannot be controlled simply by limiting exposure in the work environment. Total IgE (T-IgE) levels were significantly higher in S-IgE-positive workers than in S-IgE-negative workers (geometric mean, 200.5 and 51.3 IU/ml, respectively; p<0.002, unpaired t test). These findings demonstrate that workers in whom S-IgE is less likely to be produced, i.e., those in whom the T-IgE level is 80 IU/ml or less, should be assigned to work in these manufacturing processes. 相似文献
65.
Shiraishi M Suzuki K Abe T Kikuchi T Satoh H Nakaji S Sugawara K 《Environmental health and preventive medicine》1996,1(2):65-70
Neutrophil functions, including chemotaxis, reactive oxygen species (ROS)-producing capacity of neutrophils, and serum opsonic activity were investigated in 9 young healthy male volunteers. Venous blood of these volunteers was obtained under standardized conditions at 4-h intervals over a 24-h span. Neutrophil chemotaxis was evaluated by a modified Boyden technique, ROS-producing capacity of neutrophils and serum opsonic activity were measured by a simultaneous multiple measurement system based on luminol-dependent chemiluminescence and indicated by peak height and peak time. ROS-producing capacity of neutrophils and serum opsonic activity were activated in the daytime, and decreased from night to morning. There were negative correlations between the peak time of the luminol-dependent chemiluminescent response, neutrophil number (p<0.01) and segmented neutrophil number (p>0.01). On the other hand, no significant correlations were noted between serum opsonic activity and IgG, IgA, IgM, C3 or C4. In contrast, the peaks of neutrophil chemotaxis were at the wake-up time (6:00a.m.) and in the evening (6:00p.m.). This study indicates that diurnal variation of neutrophil function exists. 相似文献
66.
Subjective and functional results after total gastrectomy: prospective study for longterm comparison of reconstruction procedures 总被引:7,自引:0,他引:7
Shinya Adachi Satoshi Inagawa Tsuyoshi Enomoto Eiji Shinozaki Tatsuya Oda Toru Kawamoto 《Gastric cancer》2003,6(1):0024-0029
Background:
Many reconstruction procedures have been developed in efforts to resolve patients' complaints after total gastrectomy. However,
there have been few reports of longterm comparisons between reconstruction procedures, especially with regard to the prevention
of duodenal food passage. This study was undertaken to compare the longterm subjective and functional results among Roux-en-Y
esophagojejunostomy (R-Y), R-Y with pouch (P-Y), and jejunal interposition with pouch (P-I) after total gastrectomy.
Methods:
Consecutive patients requiring curative total gastrectomy were enrolled in this prospective study by the envelope method.
Results:
Hospital stay was longer following a P-I than an R-Y or a P-Y. Over 50% of R-Y patients complained of heartburn, and 20%
of R-Y patients showed dumping syndrome throughout the postoperative period, with this rate being significantly different
from rates in the other two groups. P-Y patients complained of early satiety in the late postoperative period, while P-I patients
complained of early satiety in the early postoperative period. The nutritional index in P-I patients was higher than those
in patients with the other two procedures. Gastrointestinal and hepatobiliary dual scintigraphy (GHDS) showed that the rate
of bile reflux with an R-Y was relatively high after surgery. Food reflux with a P-Y was increased (9.4% to 11.1%), but with
a P-I food reflux was decreased at 3 years after surgery (13.3% to 9.9%). Patients with a P-Y had a faster recovery of body,
weight in the early postoperative period; however, at 5 years after operation, body weight recovery with a P-I was greatest.
Conclusion:
Reconstruction should be performed with pouch formation after total gastrectomy with curative intent.
Received: March 7, 2002 / Accepted: September 26, 2002
Acknowledgments This study was partly supported by the University of Tsukuba Research Project.
Offprint requests to: S. Adachi 相似文献
67.
Daisuke Abe Toshiyuki Sakaki Tatsuya Kusudo Atsushi Kittaka Nozomi Saito Yoshitomo Suhara Toshie Fujishima Hiroaki Takayama Hiromi Hamamoto Masaki Kamakura Miho Ohta Kuniyo Inouye 《Drug metabolism and disposition》2005,33(6):778-784
Recently, we demonstrated that some A-ring-modified vitamin D3 analogs had unique biological activity. Of these analogs, 2alpha-propoxy-1alpha,25(OH)2D3 (C3O1) and 2alpha-(3-hydroxypropoxy)-1alpha,25(OH)2D3 (O2C3) were examined for metabolism by CYP27A1 and CYP24A1. Surprisingly, CYP27A1 catalyzed the conversion from C3O1 to O2C3, which has 3 times more affinity for vitamin D receptor than C3O1. Thus, the conversion from C3O1 to O2C3 by CYP27A1 is considered to be a metabolic activation process. Five metabolites were detected in the metabolism of C3O1 and O2C3 by human CYP24A1 including both C-23 and C-24 oxidation pathways. On the other hand, three metabolites of the C-24 oxidation pathway were detected in their metabolism by rat CYP24A1, indicating a species-based difference in the CYP24A1-dependent metabolism of C3O1 and O2C3 between humans and rats. Kinetic analysis revealed that the Km and kcat values of human CYP24A1 for O2C3 are, respectively, approximately 16 times more and 3 times less than those for 1alpha,25(OH)2D3. Thus, the catalytic efficiency, kcat/Km, of human CYP24A1 for O2C3 is only 2% of 1alpha,25(OH)2D3. These results and a high calcium effect of C3O1 and O2C3 in animal experiments using rats suggest that C3O1 and O2C3 are promising for clinical treatment of osteoporosis. 相似文献
68.
Wang L Kuroiwa Y Kamitani T Li M Takahashi T Suzuki Y Shimamura M Hasegawa O 《Journal of neurology》2000,247(5):356-363
To determine whether there are characteristic changes in event-related potentials (ERPs) in parkinsonian syndromes we studied
8 patients with progressive supranuclear palsy (PSP), 10 patients with corticobasal degeneration (CBD), 9 patients with striatonigral
degeneration (SND), and 16 patients with idiopathic Parkinson's disease (PD) with a mean duration of illness shorter than
5 years in each group. A visual oddball paradigm was employed to elicit P300. P300 to the rare target and rare nontarget stimuli
and reaction time (RT) to rare target stimuli in each group were compared with those in the corresponding age-matched normal
control group and to each other after age correction. The correlation of P300 and RT to motor disability score was also studied.
In PSP P300 amplitude was markedly reduced while in CBD P300 latency was prolonged. P300 amplitude to rare nontargets in SND
and PD was attenuated. The mean RT in the PSP and the CBD group was significantly longer than in the other two groups. The
mean RT in PD and P300 amplitude to rare nontargets in both CBD and PD showed significant correlation with the severity of
motor disability. Simultaneous measurement of P300 and RT may yield useful supplementary information in facilitating diagnosis
of parkinsonian syndromes in addition to clinical criteria.
Received: 6 April 1999, Received in revised form: 5 August 1999, Accepted: 12 January 2000 相似文献
69.
Masakatsu Fujinoki Tatsuya Suzuki Takeshi Takayama Hiroaki Shibahara Hideki Ohtake 《Reproductive Medicine and Biology》2006,5(2):123-135
Background and Aims It has been widely accepted that sperm hyperactivation is regulated by protein phosphorylations. But, the sperm hyperactivation
phosphorylation pathway is not well understood yet because several different proteins have been detected in other studies.
In order to understand the phosphorylation pathway that regulates hyperactivation, we established how to extract sperm protein
completely and detected proteins that were phosphorylated during hyperactivation.
Methods Protein phosphorylation of hamster spermatozoa was detected by western blotting using antiphospho-amino acid monoclonal antibodies
or the SELDI ProteinChip system with IMAC-Ga(III).
Results We detected 75 protein/peptide phosphoryations using the method established in the present study. Tyrosine phosphorylations
occurred during hyperactivation. Serine or threonine phosphorylations occurred for 30 min. Furthermore, four of the serine
or threonine phosphorations were phosphorylated by A-kinase. As for peptides, 15 peptides were dephosphorylated for 30 min.
Other peptides were phosphorylated during hyperactivation.
Conclusions Because most of the proteins detected in the present study have been described previously, we could detect comprehensive protein
phosphorylations. Moreover, we also detected many novel phosphopeptides. Although we did not understand the role of peptide,
it was likely that motility was basically regulated by serine/threonine phosphorylations and hyperactivation was mainly regulated
by tyrosine phosphorylations. (Reprod Med Biol 2006; 5: 123–135) 相似文献
70.
Virgínia Carla de Oliveira Tatsuya Nagata Felipe C. Guimarães Fernanda A. Ferreira Elliot Watanabe Kitajima Cícero Nicolini Renato de Oliveira Resende Alice Kazuko Inoue-Nagata 《Virus genes》2013,46(1):190-194
A tymovirus was isolated in Brazil from tomato plants with severe symptoms of leaf mosaic and blistering. The virus was mechanically transmissible to solanaceous indicator host species. The infected plants contained icosahedral particles and chloroplasts with membrane deformations which are typical cytopathic effects caused by tymoviruses. Its coat protein amino acid sequence shares the maximum of 64 % identity with the tymovirus Chiltepin yellow mosaic virus, which suggested that it can be considered as a distinct member of the genus Tymovirus. In a phylogenetic tree, this tymovirus was clustered with other solanaceous-infecting tymoviruses. It was tentatively named as Tomato blistering mosaic virus (ToBMV). 相似文献