全文获取类型
收费全文 | 1957篇 |
免费 | 127篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 90篇 |
妇产科学 | 33篇 |
基础医学 | 310篇 |
口腔科学 | 39篇 |
临床医学 | 136篇 |
内科学 | 478篇 |
皮肤病学 | 25篇 |
神经病学 | 102篇 |
特种医学 | 80篇 |
外科学 | 300篇 |
综合类 | 8篇 |
预防医学 | 79篇 |
眼科学 | 30篇 |
药学 | 107篇 |
中国医学 | 7篇 |
肿瘤学 | 256篇 |
出版年
2023年 | 11篇 |
2022年 | 43篇 |
2021年 | 58篇 |
2020年 | 45篇 |
2019年 | 45篇 |
2018年 | 55篇 |
2017年 | 42篇 |
2016年 | 35篇 |
2015年 | 36篇 |
2014年 | 65篇 |
2013年 | 75篇 |
2012年 | 118篇 |
2011年 | 156篇 |
2010年 | 74篇 |
2009年 | 66篇 |
2008年 | 104篇 |
2007年 | 114篇 |
2006年 | 129篇 |
2005年 | 124篇 |
2004年 | 97篇 |
2003年 | 91篇 |
2002年 | 107篇 |
2001年 | 25篇 |
2000年 | 43篇 |
1999年 | 40篇 |
1998年 | 34篇 |
1997年 | 21篇 |
1996年 | 27篇 |
1995年 | 20篇 |
1994年 | 17篇 |
1993年 | 21篇 |
1992年 | 16篇 |
1991年 | 13篇 |
1990年 | 6篇 |
1989年 | 6篇 |
1988年 | 7篇 |
1987年 | 17篇 |
1986年 | 13篇 |
1985年 | 10篇 |
1984年 | 7篇 |
1983年 | 6篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1980年 | 6篇 |
1978年 | 5篇 |
1973年 | 3篇 |
1971年 | 8篇 |
1969年 | 5篇 |
1968年 | 3篇 |
1966年 | 5篇 |
排序方式: 共有2095条查询结果,搜索用时 0 毫秒
41.
Miyakawa R Ichida T Yamagiwa S Miyaji C Watanabe H Sato Y Yokoyama H Tsukada C Ishimoto Y Sugahara S Yang XH Abo T Asakura H 《Journal of gastroenterology and hepatology》2005,20(7):1126-1130
The human liver contains significant numbers of innate immune cells, such as natural killer (NK) cells and natural killer T (NKT) cells, which express both T-cell receptors and NK-cell receptors simultaneously. It has been suggested that the innate immune system plays a crucial role in the liver. In this report, the distribution of NK and NKT cells in the liver and peripheral blood of two patients with drug-induced fulminant hepatic failure (FHF) who had undergone living donor liver transplantation was examined. In both the liver and peripheral blood, the proportions of NK and NKT cells markedly decreased compared with those in healthy donors. It was also revealed that, unlike murine NKT cells, human CD56(+) T cells and CD57(+) T cells did not constitutively express CD28, which is one of the important costimulatory molecules on T cells. Additionally, the residual CD56(+) T cells and CD57(+) T cells in the patients expressed more CD28 than in controls. This result suggests that NKT cells might be more activated in FHF. Although the accumulation of further cases is required, it is suggested that both NK and NKT cells might be involved in hepatic injury in FHF. 相似文献
42.
Takeshi Igarashi Tatsuhiko Kurose Kouichi Itabashi Ikuo Nakano Kenzo Okamoto Ayako Sano Kiyonobu Kimura Hiroshi Kaji 《Nihon Kokyūki Gakkai zasshi》2004,42(7):629-633
In a 43-year-old Japanese Brazilian who came to Japan in 2001, since subjective symptoms such as cough, sputum, and dyspnea on exertion had become severe, he was referred to our hospital because of suspicion of pulmonary tuberculosis in chest radiography and CT findings. A chest radiograph of initial examination showed interstitial shadows in both lungs with nodular, infiltrative or cavitary changes. No Mycobacterium tuberculosis was found. The mycetocyte with multipolar budding resembling the steerage of a ship, which was characteristic of Paracoccidioides was observed in sputum and transbronchial lung biopsy specimens. We cultured a fungus to show dimorphism of temperature dependency, and a diagnosis of chronic lung paracoccidioidomycosis was arrived at. By administration of ITCZ 200 mg/day, the chest radiography findings and clinical manifestations were improved. This case seems to be worthy of reporting in Japan since the affected site or organ was limited to the two lungs with multiple cavitary lesions and fibrotic changes on radiographic examination, and final diagnosis was made by cytology of sputum and pathology of TBLB specimens. 相似文献
43.
Mohammad Abd Alkhalik Basha Hossam M. Abdelrahman Maha Ibrahime Metwally Nader Ali Alayouty Nesreen Mohey Mohamed M.A. Zaitoun Hosam Nabil Almassry Hala Y. Yousef Ahmed A. El Sammak Sameh Abdelaziz Aly Hesham Youssef Algazzar Mohamed Abd El‐Aziz Mohamed Farag Walid Mosallam Waleed S. Abo Shanab Safaa A. Ibrahim Ekramy A. Mohamed Abd El Motaleb Mohamed Amira Hamed Mohamed Afifi Ola A. Harb Taghreed M. Azmy 《Journal of magnetic resonance imaging : JMRI》2021,53(1):292-304
44.
45.
Thulfiqar F. Mutar Ehab Tousson Ezar Hafez Maha Abo Gazia Seham B. Salem 《Environmental toxicology》2020,35(4):528-537
Cancer is the major cause of death and many factors that lead to its occurrences, such as environmental pollution and pesticides and other factors. Ehrlich carcinoma development depends on many things associated with the environment, nutrition, personal habits, and family history. The present study aimed to evaluate the potential protective effects of vitamin B17 (VB17) against Ehrlich ascites carcinoma (EAC) that induced kidney toxicity in female mice. The mice were divided into five groups (first group, control group; second group, VB17 group; third group, EAC group; fourth group, pretreated EAC with VB17; fifth group, cotreated EAC with VB17). Results showed the VB17 in pretreated (G4) and cotreated (G5) groups lead to an improvement in DNA damage and cytological examination, in addition significantly (P < .05) increase in Na+, red blood cell, hemoglobin, hematocrit value, mean corpuscular hemoglobin (MCH), and MCH concentration, whereas significantly (P < .05) decrease in urea, creatinine, K+, platelets, and white blood cells while insignificant (P < .05) changes in mean corpuscular volume when compared to the EAC group. Many histopathological changes were observed in kidney sections in EAC as marked damage and degenerated, glomerular atrophy, the Malpighian corpuscles that lost their characteristic configuration. On the other hand, a moderate improvement and arrangement in the kidney histological structure in pretreated VB17 + EAC, while a mild enhancement and arrangement of the kidney structure in cotreated EAC + VB17. In addition, depletion in renal P53 and PCNA protein expression compared with the EAC group. It could be concluded that VB17 has a potential renal protective effect against EAC cells induced kidney injury. 相似文献
46.
47.
Hania S. Zayed Amr Amin Samy Alsirafy Nahla D. Elsayed Soheir Abo Elfadl Mohamed Nasreldin Dalia Enaba Zeinab Nawito 《Arab Journal Of Gastroenterology》2018,19(2):71-75
Background and study aims
Central nervous system (CNS) involvement in hepatitis C virus (HCV) infection has different facets such as anxiety, depression, cognitive impairment and vasculitis. We were interested in detecting subclinical CNS involvement in chronic HCV infected subjects with and without systemic vasculitis.Patients and methods
Nineteen patients (15 females and 4 males) with chronic HCV infection (mean age 46.5?±?7 and mean duration since diagnosis of HCV infection 4.7?±?4?years, including 6 (32%) Child-Pugh class A cirrhotic patients) and 30 age, sex and education matched healthy control subjects were studied. Thirteen patients had associated vasculitis. Patients and control subjects were assessed using the block design and comprehension subtests of Wechsler Bellevue Adult Intelligence Scale, Wechsler Memory scale (WMS), Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI). Brain HMPAO Single Photon Emission Computed Tomography (SPECT) was performed for HCV patients.Results
Patients with HCV had lower scores on the block design test compared to control subjects (8.37?±?1.89 versus 10.37?±?1.47, p?<?0.001), lower total WMS scores (43.15?±?10.49 versus 60.27?±?8.08, p?<?0.001) and higher anxiety and depression scores (16.94?±?10.46 and 37.17?±?10.38 versus 10.3?±?4.67 and 28.9?±?5.99, p?=?0.004 and 0.001, respectively). Total WMS were lower in HCV patients with vasculitis compared to those without vasculitis (39.14?±?9.3 versus 51.17?±?8.3, p?=?0.019) while the block design and comprehension tests, BAI and BDI were not significantly different between both groups. The block design and comprehension tests, WMS, BAI and BDI were not significantly different between cirrhotic and non-cirrhotic patients. Seven patients had different patterns of cerebral hypoperfusion on SPECT, and all of them had associated vasculitis. Abnormal SPECT was associated with lower total WMS scores (35.87?±?10.8 versus 46.79?±?8.6 in those with normal SPECT, p?=?0.049).Conclusions
Vasculitis may contribute to the development of neuropsychiatric involvement in HCV patients. 相似文献48.
49.
50.
Predictors for typical asthma onset from cough variant asthma. 总被引:6,自引:0,他引:6
Masaki Fujimura Yoriko Nishizawa Masaru Nishitsuji Satoshi Nomura Miki Abo Haruhiko Ogawa 《The Journal of asthma》2005,42(2):107-111
Cough variant asthma is recognized to be a precursor of asthma or preasthmatic state because nearly 30% patients with cough variant asthma develop typical asthma within several years. However, predictors for risk of typical asthma onset from cough variant asthma are unknown. Forty-one patients with cough variant asthma (median age 50 years, 13 men and 28 women), who had undertaken spirometry, bronchial reversibility test, methacholine provocation test, measurements of peripheral blood eosinophil count, serum total IgE, and specific IgE to common allergens, and induced sputum eosinophil count at presentation, were followed up with special emphasis on typical asthma onset during 1 year or more (median 4 years, range 1-12.4). Long-term inhaled corticosteroids (ICS) were taken in 27 patients. Univariate and multivariate logistic analyses were performed to determine the predictors for typical asthma onset. Asthma onset was recognized in 7 patients. Bronchial hyperresponsiveness, peripheral blood eosinophil count, and no use of ICS were significant predictors for the typical asthma onset by univariate analysis. However, only bronchial hyperresponsiveness was the significant predictor when multivariate analysis was used (adjusted OR 0.028, 95% CI 0.001-0.783, p = 0.0355). Bronchial hyperresponsiveness may be the most important predictor for risk of typical asthma onset from cough variant asthma. 相似文献