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81.
Tanya Mokhateb-Rafii Martin Bialer Shaun Rodgers Christine Moore Todd Sweberg 《The Journal of emergency medicine》2019,56(1):e1-e4
Background
RIPPLY2-associated spondylocostal dysostosis is a rare disorder that leads to segmentation defects of the vertebrae. These vertebral defects can result in severe instability of the cervical spine, leading to cardiac arrest after only minor whiplash injury.Case Report
We present the case of a healthy 7-year-old child who experienced an out-of-hospital cardiac arrest. He was reported to have profound respiratory distress and collapsed after going down a slide, without trauma. He was resuscitated in the field, and presented to the emergency department, where return of spontaneous circulation was achieved. Imaging of his cervical spine revealed multiple abnormalities. It was determined that a whiplash injury led to hypoxia and bradycardia due to the anatomic abnormalities of his cervical spine, resulting in cardiovascular collapse. He recovered fully and was later diagnosed with SCDO6, an autosomal recessive inherited disorder caused by a mutation in the RIPPLY2 gene.Why Should an Emergency Physician Be Aware of This?
Unfamiliarity of providers with this mechanism of cardiac arrest, and the rarity of the syndrome itself, make early recognition very difficult. Late diagnosis and lack of preventative measures, including immediate cervical spine stabilization, can lead to catastrophic outcomes. In patients with cardiac arrest of unclear etiology, early consideration of cervical spine immobilization and evaluation can be lifesaving. 相似文献82.
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Phenuiviridae is a large family of arthropod-borne viruses with over 100 species worldwide. Several cause severe diseases in both humans and livestock. Global warming and the apparent geographical expansion of arthropod vectors are good reasons to seriously consider these viruses potential agents of emerging diseases. With an increasing frequency and number of epidemics, some phenuiviruses represent a global threat to public and veterinary health. This review focuses on the early stage of phenuivirus infection in mammalian host cells. We address current knowledge on each step of the cell entry process, from virus binding to penetration into the cytosol. Virus receptors, endocytosis, and fusion mechanisms are discussed in light of the most recent progress on the entry of banda-, phlebo-, and uukuviruses, which together constitute the three prominent genera in the Phenuiviridae family. 相似文献
85.
Chudi O. Ndubaku Terry&#;D. Crawford Huifen Chen Jason&#;W. Boggs Joy Drobnick Seth F. Harris Rajiv Jesudason Erin McNamara Jim Nonomiya Amy Sambrone Stephen Schmidt Tanya Smyczek Philip Vitorino Lan Wang Ping Wu Stacey Yeung Jinhua Chen Kevin Chen Charles&#;Z. Ding Tao Wang Zijin Xu Stephen E. Gould Lesley J. Murray Weilan Ye 《ACS medicinal chemistry letters》2015,6(8):913-918
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Hooker Jonathan C. Hamilton Gavin Park Charlie C. Liao Steven Wolfson Tanya Dehkordy Soudabeh Fazeli Hong Cheng William Mamidipalli Adrija Gamst Anthony Loomba Rohit Sirlin Claude B. 《Abdominal imaging》2019,44(2):482-492
Abdominal Radiology - To determine the inter-reader agreement of magnetic resonance imaging proton density fat fraction (PDFF) and its longitudinal change in a clinical trial of adults with... 相似文献
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Tanya Manasita Teh Kai Liang Das Lena Hoh Sook Fun Gao Xiaocong Arkachaisri Thaschawee 《Clinical rheumatology》2020,39(11):3455-3464
Clinical Rheumatology - To examine the clinical characteristics, treatment and outcomes of juvenile idiopathic arthritis (JIA) patients evaluated in Singapore and compare those with reports... 相似文献